The Secret Lives of Transcription Factors : In Heterochromatin Regulation

"This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development."--Provided by publisher Contents Chapter 1: HP1 and Noncanonical Functions of STAT STAT HP1 Summary References Chapter 2: Biological Functions of STAT, HP1, and Heterochromatin Heterochromatin Loss During Aging Heterochromatin Redistribution in Cellular Senescence Cellular Senescence Versus Cancer Development STAT and HP1 Protect Against DNA Damage and Promote Longevity References Chapter 3: Other Transcription Factors with Noncanonical Functions in Heterochromatin Regulation GAGA Factor Rb ATF2 NF-κB PAX C/EBPα References Chapter 4: HP1 in Liquid–Liquid Phase Separation and its Regulation by 53BP1 Liquid–Liquid Phase Separation and HP1 53BP1 53BP1 and Proteins in DNA Damage Response Cell Cycle Phase-Dependent DNA Damage Repair Other Pathways in DNA Damage Response 53BP1 in Heterochromatin Regulation References Index