The Science and Business of Drug Discovery : Demystifying the Jargon

__The Science and Business of Drug Discovery__ is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: * Different types of drugs: from small molecules to stem cells * Background to chemistry of small and large molecules * Historical background to drug discovery, pharmacology and biotechnology * The drug discovery pipeline: from target discovery to marketed medicine * Commercial aspects of drug discovery * Challenges to the biopharmaceutical industry and its responses * Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators Front Matter ....Pages i-xvii Introduction (Edward D. Zanders)....Pages 1-7 Front Matter ....Pages 9-9 Introduction to Drugs and Drug Targets (Edward D. Zanders)....Pages 11-30 Background to Chemistry of Small and Large Molecules (Edward D. Zanders)....Pages 31-56 Laying the Foundations: Drug Discovery from Antiquity to the Twenty-First Century (Edward D. Zanders)....Pages 57-91 Front Matter ....Pages 93-93 Drug Discovery Pipeline Overview (Edward D. Zanders)....Pages 95-98 Target Discovery (Edward D. Zanders)....Pages 99-142 Medicinal Chemistry (Edward D. Zanders)....Pages 143-163 Biotherapeutics (Edward D. Zanders)....Pages 165-186 Screening for Hits (Edward D. Zanders)....Pages 187-197 Manufacturing and Formulation (Edward D. Zanders)....Pages 199-214 Preclinical Development (Edward D. Zanders)....Pages 215-237 Front Matter ....Pages 239-239 Clinical Trials (Edward D. Zanders)....Pages 241-265 Regulatory Affairs and Marketing Approval (Edward D. Zanders)....Pages 267-279 Diagnostics and Personalized Medicine (Edward D. Zanders)....Pages 281-304 Pulling It All Together: A Drug Development Case History (Edward D. Zanders)....Pages 305-315 Front Matter ....Pages 317-317 Commercial Aspects of Drug Development (Edward D. Zanders)....Pages 319-340 Challenges and Responses (Edward D. Zanders)....Pages 341-361 Front Matter ....Pages 363-363 Technology Transfer Executives (Edward D. Zanders)....Pages 365-371 Recruitment Executives (Edward D. Zanders)....Pages 373-376 Pharmaceutical Translators and Interpreters (Edward D. Zanders)....Pages 377-382 Back Matter ....Pages 383-402