The Rose and Mackay Textbook of Autoimmune Diseases, 7e (Aug 9, 2024)_(0443239460)_(Academic Press).pdf

In dedication of Professor Rose and Professor Mackay who both passed away in 2020. A global group on experts in the field updated this Seventh Edition of The Autoimmune Diseases. The Rose-Mackay Textbook of Autoimmune Diseases, is a comprehensive reference that emphasizes the "3 P's" of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. The new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field. The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.Provides new research on autoimmune diseases, their diagnosis, prevention, and therapyCovers a complete range of all common, rare and new autoimmune diseases, including cancer and COVIDExtensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseasesSupplemented with a website that hosts a Podcast per chapter The Rose and Mackay Textbook of Autoimmune Diseases Copyright Dedication Contents to Volume 1 prelims1-volume2.pdf Contents to Volume 2 List of contributors List of editors and section editors Editors Section editors Basic science Ear nose and throat Dermatology Endocrinology Hematology Hepatobiliary and gastroenterology Nephrology Neurology Ophthalmology Pulmonary Rheumatology Preface 1 Development of adaptive immune cells Self versus nonself Adaptive immune cell development Lymphocyte progenitors T cell development Altered mechanisms of T cell tolerance as promoters of autoimmunity B cell development Antibody diversity Self-reactive B cells are inherently part of the peripheral B cell pool Altered mechanisms of B cell tolerance and autoimmunity Conclusion Acknowledgment References 2 Revision to the origins of the mononuclear phagocyte Key points Overview Steady-state development of macrophages Transcriptional regulation of tissue-resident macrophages Common macropha