The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases (Advances in Experimental Medicine and Biology Book 1161)

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, __Advances in Experimental Medicine and Biology (AEMB).__ The book in this series will be titled __Bioactive Lipids in Cancer, Inflammation and Related Diseases.__ Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others. Front Matter ....Pages i-ix Introduction (Kenneth V. Honn, Darryl C. Zeldin)....Pages 1-2 Understanding the Role of Pro-resolving Lipid Mediators in Infectious Keratitis (Elizabeth A. Berger)....Pages 3-12 Immunoresolvent Resolvin D1 Maintains the Health of the Ocular Surface (Darlene A. Dartt, Robin R. Hodges, Charles N. Serhan)....Pages 13-25 The Evolving Role of Specialized Pro-resolving Mediators in Modulating Neuroinflammation in Perioperative Neurocognitive Disorders (Ting Yang, Niccolò Terrando)....Pages 27-35 Relationship Between Specialized Pro-resolving Mediators and Inflammatory Markers in Chronic Cardiac Disorders (M. Brianza-Padilla, R. Bojalil)....Pages 37-44 Specialized Pro-resolving Mediators Directs Cardiac Healing and Repair with Activation of Inflammation and Resolution Program in Heart Failure (Ganesh V. Halade, Bochra Tourki)....Pages 45-64 Novel n-3 Docosapentaneoic Acid-Derived Pro-resolving Mediators Are Vasculoprotective and Mediate the Actions of Statins in Controlling Inflammation (Jesmond Dalli, Kimberly Pistorius, Mary E. Walker)....Pages 65-75 Aspects of Prostaglandin Glycerol Ester Biology (Philip J. Kingsley, Carol A. Rouzer, Amanda J. Morgan, Sachin Patel, Lawrence J. Marnett)....Pages 77-88 Targeting the COX/mPGES-1/PGE2 Pathway in Neuroblastoma (Karin Larsson, Anna Kock, Per Kogner, Per-Johan Jakobsson)....Pages 89-100 Metabolomics Biomarkers for Precision Psychiatry (Pei-an (Betty) Shih)....Pages 101-113 Cytochrome P450 Eicosanoid Signaling Pathway in Colorectal Tumorigenesis (Weicang Wang, Katherine Z. Sanidad, Guodong Zhang)....Pages 115-123 Contributions of 12/15-Lipoxygenase to Bleeding in the Brain Following Ischemic Stroke (Yi Zheng, Yu Liu, Hulya Karatas, Kazim Yigitkanli, Theodore R. Holman, Klaus van Leyen)....Pages 125-131 Systematic Understanding of Bioactive Lipids in Neuro-Immune Interactions: Lessons from an Animal Model of Multiple Sclerosis (Yasuyuki Kihara)....Pages 133-148 Role of Bioactive Sphingolipids in Inflammation and Eye Diseases (Koushik Mondal, Nawajes Mandal)....Pages 149-167 Roles of Ceramides and Other Sphingolipids in Immune Cell Function and Inflammation (Sabrin Albeituni, Johnny Stiban)....Pages 169-191 Bioactive Lipids in Cancer, Inflammation and Related Diseases (Emma Leishman, Phillip E. Kunkler, Joyce H. Hurley, Sally Miller, Heather B. Bradshaw)....Pages 193-217 Novel Anti-inflammatory and Vasodilatory ω-3 Endocannabinoid Epoxide Regioisomers (Lauren N. Carnevale, Aditi Das)....Pages 219-232 Overview of Lipid Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (Andres Trostchansky)....Pages 233-241 Flavonoids Ability to Disrupt Inflammation Mediated by Lipid and Cholesterol Oxidation (Carlo Barnaba, Ilce G. Medina-Meza)....Pages 243-253 Back Matter ....Pages 255-257 This book examines the role of bioactive lipids as pro- and anti-inflammatory mediators in the diagnosis of and as novel therapies for cardiovascular disease, cancer, ocular and neurologic diseases, and inflammatory conditions. The major pathways of arachidonic acid and omega-3 fatty acid metabolism are represented, including cyclooxygenases, lipoxygenases, cytochrome P450 monooxygenases, specialized pro-resolving mediators, endocannabinoids, and ceramide and other sphingolipids. This book would be of great interest to basic and translational researchers, as well as physician-scientists working on selected topics (e.g., cancer, cardiovascular disease, stroke, diabetes, inflammation, etc.) in which the underlying role of lipid mediators in the pathophysiology is known or suspected. This compilation of peer-reviewed manuscripts represents reviews of timely topics presented at the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases. Authors selected are outstanding junior investigators representative of future leaders in the field of bioactive lipids.