The Rise of Fetal and Neonatal Physiology: Basic Science to Clinical Care (Perspectives in Physiology)

This second edition offers an expanded and updated history of the field of fetal and neonatal development, allowing readers to gain a comprehensive understanding of the biological aspects that contribute to the wellbeing or pathophysiology of newborns. In this concluding opus of a long and prominent career as a clinical scientist, Dr. Longo has invited new contributions from noted colleagues with expertise in various fields to provide a historical perspective on the impact of how modern concepts emerged in the field of fetal physiology and contributed to the current attention paid to the fetal origins of diseases in adults. In addition to new chapters on maternal physiology and complications during pregnancy, others trace the history of the Society for Reproductive Investigation, governmental funding of perinatal research, and major initiatives to support training in the new discipline of maternal fetal medicine, including the Reproductive Scientist Development program. The extensive survey provided by the author, who personally knew most of the pioneers in the field, offers a unique guide for all clinical and basic scientists interested in the history of – and future approaches to diagnosing and treating – pathologies that represent the leading causes of neonatal mortality and, far too often, life-long morbidity. Front Matter ....Pages i-xxxi Introduction (Lawrence D. Longo)....Pages 1-7 A Scientific Genealogy: Early Development of Fetal-Neonatal Research (Lawrence D. Longo)....Pages 9-46 Oxford and the Development of Physiology, with Notes on the Nuffield Institute for Medical Research (Lawrence D. Longo)....Pages 47-67 Geoffrey S. Dawes: A Life in Science (Lawrence D. Longo)....Pages 69-84 Fetal Asphyxia and the Primate Colony in Puerto Rico (Lawrence D. Longo)....Pages 85-101 The Pulmonary Vasculature and Dawes’ Foetal and Neonatal Physiology (Lawrence D. Longo)....Pages 103-118 Embryology and Early Developmental Physiology (Lawrence D. Longo)....Pages 119-152 Some Aspects of the Physiology of the Placenta (Lawrence D. Longo)....Pages 153-194 Some Aspects of Endocrinology of the Placenta (Lawrence D. Longo)....Pages 195-215 Maternal Physiology of Pregnancy (Lawrence D. Longo)....Pages 217-280 Maternal Complications of Pregnancy that Affect Fetal Development (Lawrence D. Longo)....Pages 281-364 Fetal Growth and Its Restriction (Lawrence D. Longo)....Pages 365-412 Fetal-Neonatal Growth and Metabolism (Lawrence D. Longo)....Pages 413-422 Fetal Growth Restriction at High Altitude: Clinical Observations (Lawrence D. Longo)....Pages 423-434 Fetal Growth Restriction at High Altitude: Basic Cellular and Subcellular Physiologic Considerations (Lawrence D. Longo)....Pages 435-499 Epigenetics and the Fetal Origins of Adult Health and Disease (Lawrence D. Longo)....Pages 501-534 Some Aspects of the Developing Brain and Nervous System (Lawrence D. Longo)....Pages 535-555 Related Developments in Fetal and Neonatal Endocrinology (Lawrence D. Longo)....Pages 557-579 Further Developments in Fetal and Neonatal Physiology (Lawrence D. Longo)....Pages 581-629 Additional Clinical Aspects of Developmental Physiology and Clinical Care (Lawrence D. Longo)....Pages 631-671 Governmental Support of Research in Fetal and Newborn Physiology (Lawrence D. Longo)....Pages 673-690 Bioethical Issues in Research on the Fetus and Newborn Infant (Lawrence D. Longo)....Pages 691-701 Textbooks, Monographs, and Other Volumes on Fetal and Newborn Physiology (Lawrence D. Longo)....Pages 703-714 Fetal “Breathing” in the 1970s and Fetal Heart Rate Analysis in the 1980s and Early 1990s (Lawrence D. Longo)....Pages 715-743 Dawes’ Contributions to Symposia and a Summing Up (Lawrence D. Longo)....Pages 745-756 Dawes as a Mentor: Reminisces of Former Graduate Students, Postdoctoral Fellows, and Associates (Lawrence D. Longo)....Pages 757-782 Early Years of the Society for Reproductive Investigation (Formerly Society for Gynecologic Investigation), the Fetal and Neonatal Physiological Society, and Several Other Groups (Lawrence D. Longo)....Pages 783-796 The Reproductive Scientist Development Program and Related Programs (Lawrence D. Longo)....Pages 797-820 Epilogue (Lawrence D. Longo)....Pages 821-842 Back Matter ....Pages 843-860 This second edition offers an expanded and updated history of the field of fetal and neonatal development, allowing readers to gain a comprehensive understanding of the biological aspects that contribute to the wellbeing or pathophysiology of newborns. In this concluding opus of a long and prominent career as a clinical scientist, Dr. Longo has invited new contributions from noted colleagues with expertise in various fields to provide a historical perspective on the impact of how modern concepts emerged in the field of fetal physiology and contributed to the current attention paid to the fetal origins of diseases in adults. In addition to new chapters on maternal physiology and complications during pregnancy, others trace the history of the Society for Reproductive Investigation, governmental funding of perinatal research, and major initiatives to support training in the new discipline of maternal fetal medicine, including the Reproductive Scientist Development prog ram. The extensive survey provided by the author, who personally knew most of the pioneers in the field, offers a unique guide for all clinical and basic scientists interested in the history of - and future approaches to diagnosing and treating - pathologies that represent the leading causes of neonatal mortality and, far too often, life-long morbidity