The Reticuloendothelial System and Atherosclerosis : Proceedings of an International Symposium on Atherosclerosis and the Reticuloendothelial System, Held in Como, Italy, September 8–10, 1966

The circulatory system is usually considered to be composed of tubes of various diameters, characterized by collateral and terminal branches. There is also a tendency to treat blood vessels merely as conducting tubes in which the various structures of the wall act as mechanical pumps wlrich modify their diameter. This is, of course, not so. In fact, we know that blood vessels, and in particular arteries, are organs with personalities of their own and a particular susceptibility to several diseases. In addition, blood vessels differ in structure, according to their localization, and age at differing rates. The experimental work car­ ried out so far clearly confirms the data that have come from spontaneous human pathology; experimentally induced arterial lesions have a definite tendency to appear in certain arteries and not in others, depending on the experimental procedures used, and in each specific artery the lesions appear to have a specific location. We now know that the arterial wall is a metabo­ licallyactive structure, in which a number of enzyme activities have been clearly demonstrated. It possesses a sensitive vasa vasorum apparatus and a specific reactivity to various lesion-inducing stimuli. We must also remember that the arterial wall is in continuous contact with the blood circulating through the endothelial cells lining the vascular bed. It is obvious, therefore, that any variation in the circulating blood mass can modify the morphology as well as the function of the vessel wall. Front Matter....Pages i-xii Application of a Mathematical Model to the Study of RES Phagocytosis in Mice....Pages 1-17 The Use of Radioiodinated Latex Particles for in Vivo Studies of Phagocytosis....Pages 18-24 Interaction of Charged Colloids with the RES....Pages 25-33 The Potential Use of Glutaraldehyde-Fixed Liver Cells in the Study of Hepatic Reticuloendothelial and Parenchymal Cell Metabolism....Pages 34-45 The Function of the Reticuloendothelial System Studied with Isolated Perfused Rat Livers....Pages 46-57 Reticuloendothelial Excretion Via the Bronchial Tree....Pages 58-62 Kinetics of the Phagocytosis of Repeated Injections of Colloidal Carbon: Blockade, a Latent Period or Stimulation? A Question of Timing and Dose....Pages 63-73 Comparative Morphology of Macrophages in Tissue Culture....Pages 74-84 Fine Structural Aspects of Reticuloendothelial Blockade....Pages 85-97 The Cellular Basis of RE Stimulation: The Effects on Peritoneal Cells of Stimulation with Glyceryl Trioleate, Studied by EM and Autoradiography....Pages 98-107 Cytodynamics of Rat Lung in Response to Freund’s Adjuvant....Pages 108-120 Esterase Histochemistry of Reticuloendothelial Cells....Pages 121-132 Comparative Cytology of Alveolar and Peritoneal Macrophages from Germfree Rats....Pages 133-146 The Role of the Environment in Determining the Discriminatory Activity of the Human Phagocytic Cell....Pages 147-162 Some Effects of Divalent Cations on In Vitro Phagocytosis....Pages 163-174 The Engulfing Potential of Peritoneal Phagocytes of Conventional and Germfree Mice....Pages 175-187 Pharmacological Stimulation and Depression of the Phagocytic Function of the RES....Pages 188-196 The Action of Some Natural Substances on the RES....Pages 197-202 Effect of Bacillus Calmette Guerin on the Metabolism of Alveolar Macrophages....Pages 203-213 Reticuloendothelial System Stimulation by Estrogens and Thorium Dioxide Retention in Rat Liver....Pages 214-220 The Effects of Steroid Hormones on Local and General Reticuloendothelial Activity: Relation of Steroid Structure to Function....Pages 221-242 The Quantitative Response of the Host Defense System after Stimulation....Pages 243-255 The Dissimilar Effects of Two RES Stimulants on Shock....Pages 256-265 Comparative Effect of Endotoxin and Reticuloendothelial “Blocking” Colloids on Selected Inducible Liver Enzymes....Pages 266-274 On the Nature of Some Nonspecific Host Responses in Endotoxin-Induced Resistance to Infection....Pages 275-284 The Effect of Opsonized Colloids on the Enhancement of Endotoxin Lethality....Pages 285-292 The Effect of a Reticuloendothelial-Depressing Substance on Survival From Shock....Pages 293-299 Effect of Dextrans on Bacterial Infections in Mice....Pages 300-314 Prevention and Treatment of Friend Leukemia Virus (FLV) Infection by Interferon-Inducing Synthetic Polyanions....Pages 315-332 Immunoglobulin Synthesis in the Rat....Pages 333-344 Modifications of Antibody Synthesis by Chloramphenicol....Pages 345-356 Arthritis—An Example of Inflammation Based on Particles....Pages 357-368 A Major Fault in Diabetic Inflammation: Failure of Leucocytic Glycogen Transfer to Histiocytes....Pages 369-381 Participation of Hepatic Parenchymal and Kupffer Cells in Chylomicron and Cholesterol Metabolism....Pages 382-403 Importance of Aging in the Relationships Between the Reticuloendothelial System and Cholesterol Transport....Pages 404-412 Arteriopathy Induced By Reticuloendothelial Blockade....Pages 413-425 A Form of Immunological Atherosclerosis....Pages 426-432 Synthetic Cholesterol-Ester Antigens in Experimental Atherosclerosis....Pages 433-441 Atherosclerosis Induced Experimentally By Repeated Intravenous Administration of Hypercholesterolemic Serum and of Lipoproteins....Pages 442-450 Experimental Arteriopathy Induced in the Rabbit Through Rat Aorta Homogenate Injections: A Study of the Aortic Tissue Specificity....Pages 451-467 Enzymatic Activity of the Serum and the Aortic Wall in Animals Immunized by Homologous and Heterologous Aortic Extracts....Pages 468-483 Phagocytosis of Platelets by Monocytes in Organizing Arterial Thrombi....Pages 484-487 Platelets, Atherosclerosis, and Lipid Metabolism....Pages 488-491 Plasma Clearance of Products of Fibrinolysis....Pages 492-502 Back Matter....Pages 503-516