ژنوم تنظیمی: شبکه‌های تنظیمی ژن در توسعه و تکامل

Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. * The only book in the market that is solely devoted to the genomic regulatory code for animal development * Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding * Presents a comprehensive treatment of molecular control elements that determine the function of genes * Provides a comparative treatment of development, based on principles rather than description of developmental processes * Considers the evolutionary processes in terms of the structural properties of gene regulatory networks * Includes 42 full-color descriptive figures and diagrams CoverPage......Page 1 CopyRight......Page 4 Contents......Page 6 Preface......Page 10 THE FRAMEWORK......Page 14 THE REGULATORY APPARATUS ENCODED IN THE DNA......Page 16 THE REGULATORY DEMANDS OF DEVELOPMENT......Page 29 EVOLUTION, DEVELOPMENT, ANDTHE REGULATORY GENOME......Page 40 GENERAL OPERATING PRINCIPLES......Page 44 MODULARITY, A GENERAL PROPERTY OF GENOMICcis-REGULATORY CONTROL UNITS......Page 46 INSIDE THE cis-REGULATORY MODULE......Page 60 cis-REGULATORY DESIGN......Page 74 CONTROL BY SEQUENCE-SPECIFIC INTERACTIONS AMONGDISTANT cis-REGULATORY ELEMENTS......Page 91 DEVELOPMENTAL PROCESSES OF THEPREGASTRULAR EMBRYO......Page 100 COMPARATIVE VIEW OF EMBRYONIC PROCESSES, ANDTHE ORGANIZATION OF THE UNDERLYING GENEREGULATORY NETWORKS......Page 115 REGULATORY STATE AND NETWORK CIRCUITRY INBUILDING ADULT BODY PARTS......Page 127 BODY PLAN DEVELOPMENT AND THE ORGANISM......Page 135 CHAPTER 4 Gene Regulatory Networks forDevelopment......Page 138 GENERAL STRUCTURAL PROPERTIES OF DEVELOPMENTALGENE REGULATORY NETWORKS......Page 139 GENE REGULATORY NETWORKS FOR EMBRYONICDEVELOPMENT......Page 157 NETWORKS THAT CONTROL CONSTRUCTIONOF COMPONENTS OF ADULT BODY PARTS......Page 188 CONCLUDING REMARKS......Page 197 CHAPTER 5 Gene Regulatory Networks: The Roots of Causality......Page 200 EVOLUTIONARY IMPLICATIONS OF THE STRUCTURE ANDFUNCTION OF GENE REGULATORY NETWORKS......Page 201 BILATERIAN KERNELS, PREDICTED AND REAL......Page 209 SUBPHYLETIC EVOLUTION OF BILATERIAN BODY PLANS......Page 236 METAZOAN ORIGINS AND GENE NETWORKSBEFORE KERNELS......Page 248 References......Page 254 Figure Citations......Page 288 Index......Page 292 The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body-plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. It is clearly written with the object of explaining regulatory causality without requiring of the reader a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. Animal body plans, their structures and the functions with which their morphology endows them, are the integrals over time and space of their successive developmental processes.