The Primate Nervous System, Part III (Volume 15) (Handbook of Chemical Neuroanatomy, Volume 15)

This volume is the third and final part of the planned coverage of the neurochemical circuitry of the primate central nervous system. The five chapters included in this volume complement and integrate magnificently with the two prior volumes. Included in the volume are the following: a two-fold exposition on the human forebrain, comprised of a comprehensive overview of the entire human forebrain, and a specific focus on the basal forebrain (a region critical for a wide range of human problems ranging from substance abuse to Alzheimer's disease), a critical synthesis of the primate basal ganglia (a region under intense scrutiny for the organization of motor programs, and for their dysfunctions in Parkinson's disease, Huntington's disease and other malfunctions), the chemical and anatomic details of the primate hippocampal formation in extenso, and lastly, a review of the rapidly growing literature on the mesocortical projection of dopaminergic circuits onto the primate frontal cortex ( a system highly linked to higher order mental abstractions, as well as the dysfunctions of schizophrenia). Scholars will recognize that the laying out of these status reports on our still vastly incomplete examination of the primate brains is an opportunity for progress. This Volume Is The Second In The Planned Coverage Of The Neurochemical Circuitry Of The Primate Central Nervous System. While This Volume Contains Only Two Chapters, Their Topics And The Extraordinarily Comprehensive Coverage With Which The Authors Have Dealt With Their Topics, Will Nevertheless Contribute Equal Amounts Of Knowledge, Wisdom, And Opportunities For Future Research Extensions As Have Every Volume In This Unique Series. As Such, These Chapters Extend The Goals Of This Primate Series To Develop A Broad Coverage Of Human And Non-human Primate Chemical Neuroanatomic Details In A Volume Which Makes Clear The Known And Desirable Appreciation For Differences Between And Among Subsets Of Primate Brains. The First Chapter Covers The Primate Thalamus With Equal Emphases On New World, Old World, Pro-simian And Human Anatomic Details And Their Differences. The Second Undertakes A Comparably Comprehensive Examination Of One Of The Most Intensively Studied Regions Of The Primate Brain, Namely The Primate Visual Cortex. While Much Has Been Studied, Both Chapters Also Reveal How Much Remains For Future Efforts In These Enormously Important Regions Which Are The Archetypes Of Primate Sub-cortical And Cortical Function. Pt. 1. 1997 -- Pt. 2. 1998 -- Pt. 3. 1999. [pt. 1.] A Digital Rosetta Stone For Primate Brain Terminology / D.m. Bowden, R.f. Martin -- Neurobiology And Neuropathology Of The Human Hypothalamus / D.f. Swaab -- Caudal Pons And Medulla Oblongata / W.w. Blessing, W.p. Gai -- The Primate Locus Coeruleus : The Chemical Neuroanatomy Of The Nucleus, Its Efferent Projections, And Its Target Receptors / S.l. Foote -- The Cholinergic System In The Primate Brain : Basal Forebrain And Pontine-tegmental Cell Groups / S. De Lacalle, C.b. Saper -- Dopamine Systems In The Primate Brain / D.a. Lewis, S.r. Sesack -- Chemical Neuroanatomy Of The Primate Insula Cortex : Relationship To Cytoarchitectonics, Connectivity, Function And Neurodegeneration / E.j. Mufson, T. Sobreviela, J.h. Kordower -- Primate Cingulate Cortex Chemoarchitecture And Its Disruption In Alzheimer's Disease / B.a. Vogt, L.j. Vogt, E.a. Nimchinsky, P.r. Hof -- [pt. 2.] The Thalamus Of Primates / E.g. Jones -- Neurochemical Organization Of The Primate Visual Cortex / J.h. Morrison, P.r. Hof, G.w. Huntley -- [pt. 3.] The Human Basal Forebrain. Part 1, An Overview / N. Sakamoto, J. Pearson, K. Shinoda, G.f. Alheid, J.s. De Olmos, L. Heimer -- The Human Basal Forebrain. Part 2 / L. Heimer, J.s. De Olmos, G.f. Alheid, J. Pearson, N. Sakamoto, K. Shinoda, J. Marksteiner, R.c. Switzer Iii -- Chemical Architecture Of The Basal Ganglia / Ann M. Graybiel, John B. Penney -- Chemical Neuroanatomy Of The Hippocampal Formation And The Perirhinal And Parahippocampal Cortices / Yasushi Kobayashi, David G. Amaral -- The Primate Mesocortical Dopamine System / P.s. Goldman-rakic, C. Bergson, L.s. Krimer, M.s. Lidow, S.m. Williams, G.v. Williams. Editors, F.e. Bloom, A. Björklund, T. Hökfelt. Includes Bibliographical References And Index. This volume is the third and final part of the planned coverage of the neurochemical circuitry of the primate central nervous system. The five chapters included in this volume complement and integrate magnificently with the two prior volumes.

Included in the volume are the following: a two-fold exposition on the human forebrain, comprised of a comprehensive overview of the entire human forebrain, and a specific focus on the basal forebrain (a region critical for a wide range of human problems ranging from substance abuse to Alzheimer's disease), a critical synthesis of the primate basal ganglia (a region under intense scrutiny for the organization of motor programs, and for their dysfunctions in Parkinson's disease, Huntington's disease and other malfunctions), the chemical and anatomic details of the primate hippocampal formation in extenso, and lastly, a review of the rapidly growing literature on the mesocortical projection of dopaminergic circuits onto the primate frontal cortex ( a system highly linked to higher order mental abstractions, as well as the dysfunctions of schizophrenia).

Scholars will recognize that the laying out of these status reports on our still vastly incomplete examination of the primate brains is an opportunity for progress.
During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families. This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system. The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders. v. 1. Methods in chemical neuroanatomy v. 4. GABA and neuropetides in the CNS, pt. 1 v. 6. The Peripheral nervous system v. 7. Integrated systems of the CNS, pt. 2 v. 8. Analysis of neuronal microcircuits and synaptic interactions v. 9. Neuropeptides in the CNS v. 10. Ontogeny of transmitters and peptides in the CNS v. 11. Neuropeptide receptors in the CNS v. 12. Integrated systems of the CNS, pt. 3 v. 13. The primate nervous system v. 14. The primate nervous system, pt. 2 v. 15. The primate nervous system, pt. 3 v. 16. Peptic receptors, pt. 1 v. 18. Glutamate v. 20. Peptide receptors, pt. 2. Dopamine is a major neurotransmitter of the brain involved in the control of movement, emotion, and cognition; disturbance in dopamine function is associated with disorders like Parkinsons disease, schizophrenia and attention deficit hyperactivity disorder. This volume of the Handbook of Chemical Neuroanatomy provides a series of in depth critical reviews of our present understanding of the most important aspects of dopamines organisation and disturbed function in the animal and human brain