The Practical Applications of Prostaglandins and Their Synthesis Inhibitors

This is the fourth in a series of books on Advances in Prostaglandin Research published by MTP Press. From laboratory and animal studies a large number of practical applications of prostaglandins have been identified. In some areas clinical trials have also been carried out. There is usually a long time interval between identifying practical applications of new drugs and clinical trials. Most of the information on practical applications of prostaglandins is scattered in different journals. Although a number of books dealing with prostaglandin research have been published (including some on practical applications in specific areas, e.g. reproduction) there is no single volume dealing with all areas of practical applications of these substances. This book aims at filling this gap and should be of interest to clinicians as well as to medical and basic scientists in academic institutions and in the pharmaceutical industry. In some areas, exciting potential applications of prostaglandins have been identified from basic research but clinical trials have so far not been carried out. Such areas of practical applications are covered in a separate intro­ ductory chapter. All contributors to the volume are scientists and clinicians actively engaged in prostaglandin research and most are recognized authorities in specific areas. The need for rapid publication in a fast-expanding field is obvious. Front Matter....Pages i-x General Introduction and Practical Implications of some Pharmacological Actions of Prostaglandins, Thromboxanes and their Synthesis Inhibitors....Pages 1-24 Prostaglandins and Nasal Patency....Pages 25-38 PGE 1 in lschaemic Peripheral Vascular Disease....Pages 39-51 Prostaglandins, their Synthesis Inhibitors and Ductus Arteriosus....Pages 53-75 Prostaglandins and Angiography....Pages 77-87 Prostaglandins in Gastro-intestinal Disease....Pages 89-102 Prostaglandins and their Synthesis Inhibitors in Bartter’s Syndrome....Pages 103-137 Prostaglandins and their Synthesis Inhibitors in Migraine....Pages 139-148 Prostaglandins and Cancer....Pages 149-188 Veterinary Uses of Prostaglandins....Pages 189-216 Prostaglandins and their Synthesis Inhibitors in Primary Dysmenorrhoea....Pages 217-235 Prostaglandins and their Synthesis Inhibitors in Dysfunctional Uterine Bleeding....Pages 237-265 Menstrual Regulation with Prostaglandins....Pages 267-282 Preoperative Cervical Dilatation with Prostaglandins....Pages 283-299 Prostaglandins for Pre-induction Cervical Ripening....Pages 301-318 Termination of Abnormal Intrauterine Pregnancy with Prostaglandins....Pages 319-374 Termination of Second Trimester Pregnancy with Prostaglandins....Pages 375-409 Prostaglandins and their Inhibitors in Premature Labour....Pages 411-435 Induction of Labour with Prostaglandins....Pages 437-446 Back Matter....Pages 447-458