The Poet's Companion

Linking basic science to clinical application throughout, Histology and Cell Biology: An Introduction to Pathology, 5th Edition, helps students build a stronger clinical knowledge base in the challenging area of pathologic abnormalities. This award-winning text presents key concepts in an understandable, easy-to-understand manner, with full-color illustrations, diagrams, photomicrographs, and pathology photos fully integrated on every page. Student-friendly features such as highlighted clinical terms, Clinical Conditions boxes, Essential Concepts boxes, concept mapping animations, and more help readers quickly grasp complex information. Key Features Features new content on cancer immunotherapy, satellite cells and muscle repair, vasculogenesis and angiogenesis in relation to cancer treatment, and mitochondria replacement therapies. Presents new material on ciliogenesis, microtubule assembly and disassembly, chromatin structure and condensation, and X chromosome inactivation, which directly impact therapy for ciliopathies, infertility, cancer, and Alzheimer’s disease. Provides thoroughly updated information on gestational trophoblastic diseases, molecular aspects of breast cancer, and basic immunology, including new illustrations on the structure of the T-cell receptor, CD4+ cells subtypes and functions, and the structure of the human spleen. Uses a new, light green background throughout the text to identify essential concepts of histology – a feature requested by both students and instructors to quickly locate which concepts are most important for beginning learners or when time is limited. These essential concepts are followed by more detailed information on cell biology and pathology. Contains new Primers in most chapters that provide a practical, self-contained integration of histology, cell biology, and pathology – perfect for clarifying the relationship between basic and clinical sciences. Identifies clinical terms throughout the text and lists all clinical boxes in the table of contents for quick reference. Understand the links between chapter concepts with concept mapping animations on Student ConsultTM – an outstanding supplement to in-class instruction. Student ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. Front Cover......Page 1 Histology and Cell Biology: An Introduction to Pathology......Page 5 Copyright Page......Page 6 Dedication......Page 7 PREFACE......Page 9 Table of Contents......Page 11 Chapter 1. EPITHELIUM CELL BIOLOGY......Page 21 CLASSIFICATION OF EPITHELIA......Page 22 CELL JUNCTIONS......Page 32 CONNEXIN MUTATIONS......Page 40 CYTOSKELETON......Page 43 CILIOPATHIES......Page 50 CELL NUCLEUS......Page 58 LAMINOPATHIES......Page 60 CELL CYCLE......Page 66 BASIC CONCEPTS OF MEDICAL GENETICS......Page 78 Chapter 2. EPITHELIAL GLANDS CELL BIOLOGY......Page 87 EPITHELIAL GLANDS......Page 88 PLASMA MEMBRANE AND CYTOMEMBRANES......Page 93 LYSOSOME STORAGE DISORDERS......Page 107 MITOCHONDRIA REPLACEMENT THERAPIES......Page 113 PEROXISOME BIOGENESIS DISORDERS (PBDs)......Page 115 Chapter 3. CELL SIGNALING CELL BIOLOGY PATHOLOGY......Page 119 CELL SIGNALING MECHANISMS......Page 120 APOPTOSIS AND THE IMMUNE SYSTEM......Page 140 NEOPLASIA......Page 145 Chapter 4. CONNECTIVE TISSUE......Page 155 EHLERS-DANLOS SYNDROME......Page 160 MARFAN’S SYNDROME......Page 163 MOLECULAR BIOLOGY OF TUMOR INVASION......Page 169 ADIPOSE TISSUE OR FAT......Page 171 CARTILAGE......Page 175 BONE......Page 180 OSTEOPOROSIS......Page 190 OSTEOPETROSIS AND OSTEOMALACIA......Page 191 Chapter 5. OSTEOGENESIS......Page 197 OSTEOGENESIS......Page 198 BONE FRACTURE AND HEALING......Page 209 BONE DISORDERS......Page 211 RHEUMATOID ARTHRITIS......Page 212 Chapter 6. BLOOD AND HEMATOPOIESIS......Page 219 BLOOD......Page 220 ERYTHROBLASTOSIS FETALIS......Page 221 LEUKOCYTE RECRUITMENT AND INFLAMMATION......Page 227 MAST CELL, EOSINOPHIL AND ASTHMA......Page 228 HEMATOPOIESIS......Page 233 LEUKEMIAS......Page 247 IRON-OVERLOAD DISORDERS......Page 249 MEGALOBLASTIC ANEMIA......Page 252 Chapter 7. MUSCLE TISSUE......Page 257 SKELETAL MUSCLE......Page 258 DISORDERS OF NEUROMUSCULAR SYNAPTIC TRANSMISSION......Page 264 MUSCULAR DYSTROPHIES......Page 266 SATELLITE CELLS AND MUSCLE REPAIR......Page 269 MYOCARDIAL INFARCTION......Page 273 SMOOTH MUSCLE......Page 275 Chapter 8. NERVOUS TISSUE......Page 281 DEMYELINATING DISEASES......Page 297 Chapter 9. SENSORY ORGANS: VISION AND HEARING......Page 319 EYE......Page 320 Chapter 10. IMMUNE-LYMPHATIC SYSTEM......Page 363 COMPONENTS OF THE IMMUNE–LYMPHATIC SYSTEM......Page 364 ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS)......Page 374 HYPERSENSITIVITY REACTIONS......Page 375 INFLAMMATION......Page 380 LYMPHOID ORGANS......Page 385 THYMUS......Page 388 SPLEEN......Page 395 SICKLE CELL ANEMIA......Page 399 ASPLENIA......Page 400 Chapter 11. INTEGUMENTARY SYSTEM......Page 409 ORGANIZATION AND TYPES OF SKIN......Page 410 WOUND HEALING......Page 421 PSORIASIS......Page 422 TUMORS OF THE EPIDERMIS......Page 424 Chapter 12. CARDIOVASCULAR SYSTEM......Page 441 THE CARDIOVASCULAR SYSTEM......Page 442 AORTIC ANEURYSMS......Page 444 VASCULITIS......Page 450 EDEMA......Page 454 ATHEROSCLEROSIS......Page 455 ANGIOGENESIS AND TUMOR PROGRESSION......Page 460 THROMBOSIS, EMBOLISM AND INFARCTION......Page 461 HYPERTENSION......Page 462 Chapter 13. RESPIRATORY SYSTEM......Page 467 THE RESPIRATORY SYSTEM......Page 468 CYSTIC FIBROSIS......Page 473 CHRONIC OBSTRUCTIVE PULMONARY DISEASE......Page 487 ACUTE RESPIRATORY DISTRESS SYNDROME......Page 488 LUNG CANCER......Page 492 DISORDERS OF THE PLEURA......Page 493 Chapter 14. URINARY SYSTEM......Page 499 THE KIDNEYS......Page 500 PATHOLOGY OF THE GBM......Page 505 PODOCYTE INJURY......Page 510 Chapter 15. UPPER DIGESTIVE SEGMENT......Page 531 NON-NEOPLASTIC AND NEOPLASTIC LESIONS OF THE ORAL MUCOSA......Page 540 INFECTION WITH Helicobacter pylori......Page 553 Chapter 16. LOWER DIGESTIVE SEGMENT......Page 563 SMALL INTESTINE......Page 564 INFLAMMATORY BOWEL DISEASES......Page 582 LARGE INTESTINE......Page 583 COLORECTAL TUMORIGENESIS......Page 588 Chapter 17. DIGESTIVE GLANDS......Page 595 STRUCTURE OF A SALIVARY GLAND......Page 596 PANCREATIC TUMORS......Page 602 PANCREATITIS AND CYSTIC FIBROSIS......Page 606 LIVER......Page 607 PERISINUSOIDAL CELLS AND CHRONIC LIVERDISEASE......Page 614 CHRONIC HEPATITIS AND CIRRHOSIS......Page 616 Chapter 18. NEUROENDOCRINE SYSTEM......Page 627 HYPOPHYSIS......Page 628 GIGANTISM (IN CHILDREN) AND ACROMEGALY (IN ADULTS)......Page 633 HYPERPROLACTINEMIA......Page 635 INFERTILITY......Page 636 HYPOTHYROIDISM......Page 637 NEUROHYPOPHYSIS......Page 638 HYPOTHALAMIC DIABETES INSIPIDUS......Page 641 PINEAL GLAND......Page 642 PINEALOMAS......Page 647 Chapter 19. ENDOCRINE SYSTEM......Page 651 THYROID GLAND......Page 652 GRAVES’ DISEASE AND HYPOTHYROIDISM......Page 656 PARATHYROID GLANDS......Page 659 CaSR AND Gq/11 MUTATIONS......Page 661 DIABETES MELLITUS......Page 678 Chapter 20. SPERMATOGENESIS......Page 683 THE TESTES......Page 684 CONDITIONS AFFECTING MALE FERTILITY......Page 705 EPIGENETICS REPROGRAMMING......Page 712 TESTICULAR TUMORS......Page 715 Chapter 21. SPERM TRANSPORT AND MATURATION......Page 721 DEVELOPMENT OF THE GONADS......Page 722 SPERM MATURATION PATHWAY......Page 725 BENIGN PROSTATIC HYPERPLASIA......Page 734 PROSTATE CANCER AND TUMOR SUPPRESSOR GENES......Page 736 Chapter 22. FOLLICULOGENESIS AND MENSTRUAL CYCLE......Page 743 HYPOGONADOTROPIC HYPOGONADISM AND GnRH......Page 763 ENDOMETRIOSIS......Page 764 CERVICAL CANCER AND HIGH-RISK HUMAN PAPILLOMAVIRUS INFECTION......Page 766 DIAGNOSTIC CYTOPATHOLOGY......Page 768 Chapter 23. FERTILIZATION, PLACENTATION AND LACTATION......Page 775 FERTILIZATION......Page 776 ABNORMAL PLACENTATION......Page 791 GESTATIONAL TROPHOBLASTIC DISEASES......Page 792 LACTATION......Page 793 BENIGN BREAST DISEASES AND BREAST CANCER......Page 801 Index......Page 807

Linking basic science to clinical application throughout, Histology and Cell Biology: An Introduction to Pathology, 5th Edition, helps students build a stronger clinical knowledge base in the challenging area of pathologic abnormalities. This award-winning text presents key concepts in an understandable, easy-to-understand manner, with full-color illustrations, diagrams, photomicrographs, and pathology photos fully integrated on every page. Student-friendly features such as highlighted clinical terms, Clinical Conditions boxes, Essential Concepts boxes, concept mapping animations, and more help readers quickly grasp complex information.

• Features new content on cancer immunotherapy, satellite cells and muscle repair, vasculogenesis and angiogenesis in relation to cancer treatment, and mitochondria replacement therapies.
• Presents new material on ciliogenesis, microtubule assembly and disassembly, chromatin structure and condensation, and X chromosome inactivation, which directly impact therapy for ciliopathies, infertility, cancer, and Alzheimer’s disease.
• Provides thoroughly updated information on gestational trophoblastic diseases, molecular aspects of breast cancer, and basic immunology, including new illustrations on the structure of the T-cell receptor, CD4 cells subtypes and functions, and the structure of the human spleen.
• Uses a new, light green background throughout the text to identify essential concepts of histology – a feature requested by both students and instructors to quickly locate which concepts are most important for beginning learners or when time is limited. These essential concepts are followed by more detailed information on cell biology and pathology.
• Contains new Primers in most chapters that provide a practical, self-contained integration of histology, cell biology, and pathology – perfect for clarifying the relationship between basic and clinical sciences.
• Identifies clinical terms throughout the text and lists all clinical boxes in the table of contents for quick reference.
• Helps students understand the links between chapter concepts with concept mapping animations on Student ConsultTM – an outstanding supplement to in-class instruction.