The Platelets: Physiology and Pharmacology (Physiologic and Pharmacologic Bases of Drug Therapy)

The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet (Sa (B-granule proteins; the aspects of adenine nucleotide levels, regulation, and storage; and receptors for catecholamines and consequences of their agonism. Other chapters are devoted to the metabolism of arachidonic acid, its manipulation, consequences, and metabolite receptors. The discussion then shifts to the second-messenger entities, specifically calmodulin, calcium, and cyclic adenosine monophosphate. A chapter presents the comparisons of man and commonly used laboratory animals concerning platelet behavior variability. Another chapter looks into the use and appropriateness of the use of platelets as models of neurons, with a special emphasis on serotonergic neurons. The remaining chapters contain critical reviews of platelet involvement in diabetes, hypertension and peripheral vascular disease, atherogenesis/atherosclerosis, and ischemic heart disease. These chapters also include specific techniques for platelet analysis, including lumiaggregometry, eicosanoid measurements, and serotonin uptake and release. This book is an invaluable source for pharmacologists, biochemists, researchers, and clinicians who are interested in platelet involvement in disease Content: Physiologic and Pharmacologic Bases of Drug Therapy , Page ii Front Matter , Page iii Copyright , Page iv Contributors , Pages xi-xiii Preface , Pages xv-xvi , Gesina L. Longenecker 1 - Platelet Aggregation , Pages 1-14 , G.A. Adams 2 - Platelet Adhesion: Past and Present , Pages 15-47 , G.A. Adams 3 - Platelet α-Granule Proteins: Biochemical and Pathological Aspects , Pages 49-83 , Stefan Niewiarowski, John C. Holt 4 - Adenine Nucleotides in Blood Platelets , Pages 85-112 , Hans-Joachim Reimers 5 - Platelet Adrenoceptors , Pages 113-157 , Roger Kerry, Michael C. Scrutton 6 - Platelet Arachidonic Acid Metabolism , Pages 159-185 , Gesina L. Longenecker 7 - Hydroperoxide Metabolism and Oxidant Generation in Platelets , Pages 187-200 , Lawrence J. Marnett, Thomas A. Dix, Paul H. Siedlik, Paul Weller 8 - Platelet Eicosanoid Receptors , Pages 201-220 , Adam Myers, Hideo Shio, Simonetta Nicosia, Peter Ramwell 9 - Calmodulin and Platelet Function , Pages 221-235 , Harold P. Jones 10 - Calcium and Cyclic AMP: Antagonistic Modulators of Platelet Function , Pages 237-269 , Maurice B. Feinstein, George B. Zavoico, Stephen P. Halenda 11 - Regulation of Platelet Cyclic AMP Formation , Pages 271-288 , Klaus Aktories, Karl H. Jakobs 12 - Species Variation in Platelet Aggregation , Pages 289-305 , Daniel H. Hwang 13 - Platelets as Pharmacologic Models for the Receptors and Biochemistry of Monoaminergic Neurons , Pages 307-340 , Stephen M. Stahl 14 - Platelet Involvement in Diabetes Mellitus , Pages 341-366 , Peter D. Winocour, Perry V. Halushka, John A. Colwell 15 - Platelets in Hypertension and Peripheral Vascular Disease , Pages 367-381 , Pavel Hamet, Johanne Tremblay, Hidekatsu Sugimoto 16 - The Role of Platelets in Atherogenesis/Atherosclerosis , Pages 383-405 , Ira I. Sussman 17 - Platelets and Ischemic Heart Disease , Pages 407-428 , Andrew Szczeklik, Jacek Musiał 18 - The Lumi-Aggregometer as a Research and Clinical Tool , Pages 429-440 , Richard D. Feinman, Thomas C. Detwiler, Carol Ingerman-Wojenski 19 - Measurement of Platelet Eicosanoid Compounds , Pages 441-461 , Elisabeth Granström, Pär Westlund, Maria Kumlin 20 - Characteristics of Serotonin Uptake and Release by Platelets , Pages 463-479 , Michael B. Given, Gesina L. Longenecker Index , Pages 481-489 The Platelets: Physiology and Pharmacology is a critical review of the basic platelet systems, methodologic critiques, and platelet involvement in major disease states. This book is composed of 20 chapters that specifically deal with the physiology and biochemistry of the platelet system, along with possibilities for, and consequences of, pharmacologic manipulation. The opening chapters examine the basic processes of platelet aggregation and adhesion. These topics are followed by discussions on the types and functions of platelet Ü-granule proteins; the aspects of adenine nucleotide levels