The Pharmacology of Alcohol and Drugs of Abuse and Addiction

This volume is intended for clinicians, researchers, residents, and students. The range is wide and the depth considerable for all the topics covered in the treatment of this timely and relevant subject. This book may serve equally well as a general introduction and a scholarly reference. Ultimately, it is designed to serve those patients suffering from abuse of and addiction to drugs and alcohol. The content and organization of the book flow from general concepts of abuse and addiction to specific details of the pharmacology of alcohol and drugs. Special chapters on topics not found in most other books, such as pharmacology of drug-drug interactions, abstinence, and prevention, are included. This book is written especially for the clinician interested in the pharma­ cology of alcohol and drugs of abuse and addiction. The pharmacology is integrated into a conceptual approach to diagnosis and treatment of alcohol and drug abuse and addiction. The form and style are didactic, critical as well as straightforward in presentation. Literature references from recent clinical research and basic research provide the foundation for the chapters throughout the book. Be­ cause the book is written by a clinician-researcher, the information is readily adaptable to clinical problems and research ideas. I would like to express my deep appreciation to Susan Newsom and Darlene Tucci for their invaluable technical assistance. Norman S. Miller vii Contents Preface ....................................................... vii CHAPTER 1 Introduction to the Pharmacological Effects of Alcohol and Drugs and Addiction on the Brain and Behavior .... . . . . . . . . . . . . . . . . . .. . . 1 . . . . . . Front Matter....Pages i-xi Introduction to the Pharmacological Effects of Alcohol and Drugs and Addiction on the Brain and Behavior....Pages 1-8 The Behavioral Concepts of Abuse and Addiction in Diagnosis....Pages 9-24 The Neurochemistry of Tolerance, Dependence, and Addiction....Pages 25-43 Suicide in Alcoholism and Drug Addiction....Pages 45-53 The Genetics of Alcoholism....Pages 55-62 The Medical Consequences of Alcohol and Drugs of Abuse and Addiction....Pages 63-75 The Psychiatric Consequences of Alcohol and Drugs of Abuse and Addiction....Pages 77-87 The Pharmacology of Alcohol and Drugs and Sexual Responsivity....Pages 89-100 The Pharmacology of Alcohol....Pages 101-111 The Pharmacology of Amphetamines....Pages 113-123 The Pharmacology of Anabolic-Androgen Steroids....Pages 125-132 The Pharmacology of Benzodiazepines....Pages 133-151 The Pharmacology of Cocaine....Pages 153-172 The Pharmacology of Hallucinogens and Designer Drugs....Pages 173-183 The Pharmacology of Inhalants and Volatile Solvents....Pages 185-197 The Pharmacology of Marijuana (Cannabis)....Pages 199-213 The Pharmacology of Multiple Drug and Alcohol Addiction....Pages 215-226 The Pharmacology of Narcotics: Natural, Semisynthetic, and Synthetic....Pages 227-239 The Pharmacology of Nicotine....Pages 241-248 The Pharmacology of Nonprescription Medications....Pages 249-258 The Pharmacology of Phencyclidine....Pages 259-264 The Pharmacology of Sedatives/Hypnotics....Pages 265-278 The Pharmacology of Interactions Between Medical and Psychiatric Drugs....Pages 279-289 The Pharmacology of Drug Testing: Indications and Methodology....Pages 291-307 The Pharmacological Treatment of the Acute Intoxication and Detoxification of Alcohol and Drugs of Abuse and Addiction....Pages 307-326 The Pharmacology of Abstinence....Pages 327-333 The Nonpharmacological Treatment of Abuse and Addiction to Alcohol and Drugs....Pages 335-343 The Prevention of Abuse and Addiction to Alcohol and Drugs....Pages 345-349 Back Matter....Pages 351-365 The Pharmacology of Alcohol and Drugs of Abuse and Addiction is designed to assist the practitioner in the diagnosis and treatment of alcohol and drug abuse and addiction in clini-
cal practice. Cogent step-by-step formulae forconceptuali-
zing alcohol- and drug-related problems characterize each chapter. Specific syndromes and simple detoxification sche-
dules are described and discussed within an instructional framework aimed at providing answers to a wide range of cli-
nical problems. Topics explored include the psychiatric con-
sequences of alcohol and drugs of abuse and addiction; the neurochemistry of tolerance, dependence, and addiction;
long-term recovery from the pharmacological effects of addiction to alcohol and drugs;