The Pathology of Cardiac Transplantation : A Clinical and Pathological Perspective

This is the first book to focus entirely on the role of pathology in cardiac transplantation, linked to the clinical perspective through clinical–pathological correlation, multidisciplinary team working, and collaborative research. It provides a scientific framework with up-to-date pathological protocols and classification schemes and guides the reader through the chronological phases of the transplant process in a step-by-step approach. Topics include end-stage heart failure with pathologies encountered in the native heart, current issues surrounding donor selection, the multiple faces of rejection pathology correlated with clinical management and immunology, other post-transplant complications, details of pediatric and combined heart/other organ transplantation, and a useful practical appendix. Many high-quality images and illustrative cases are presented, along with learning points and ample references. Transplantation medicine today is continuously changing as collaborative research into novel diagnostic techniques and immunosuppressive therapies translates into improved recipient management and survival. This book is aimed at practicing transplant pathologists and specialist trainees. It will also appeal to general pathologists and to physicians and surgeons involved in cardiac transplantation who need to understand the role of pathology in the clinical management of transplant recipients. Front Matter....Pages i-xx Front Matter....Pages 1-1 Cardiac Transplantation and the Contribution of Pathology....Pages 3-10 Front Matter....Pages 11-11 Advanced End-Stage Heart Failure: Epidemiology and Management....Pages 13-20 Mechanical Circulatory Support in End-Stage Heart Failure: Bridge to Transplantation and Destination Therapy....Pages 21-32 Clinical Indications for Heart Transplantation....Pages 33-40 Pathologies Encountered in Explanted Native Hearts....Pages 41-99 Pretransplant Endomyocardial Biopsy: When and Why....Pages 101-112 Front Matter....Pages 113-113 Donor Selection Criteria: Clinical and Pathological Insights....Pages 115-135 Donor Organ Harvesting and Preservation....Pages 137-145 Perioperative Myocardial Damage to the Graft....Pages 147-152 Front Matter....Pages 153-153 Graft Failure/Dysfunction: Clinical Issues and Role of Endomyocardial Biopsy....Pages 155-169 Clinical Management of Transplant Recipients....Pages 171-184 Practical Immunology for Pathologists....Pages 185-198 Pathology of Acute Cellular Rejection....Pages 199-217 Pathology of Antibody-Mediated Rejection....Pages 219-242 “Mixed” Rejection in Heart Transplantation....Pages 243-250 Pathological Non-rejection Findings in the Endomyocardial Biopsy....Pages 251-263 Noninvasive Tools for Monitoring Acute Cardiac Allograft Rejection: State of the Art....Pages 265-277 Cardiac Allograft Vasculopathy....Pages 279-305 Front Matter....Pages 307-307 Infections....Pages 309-327 Malignancies After Heart Transplantation....Pages 329-352 Front Matter....Pages 307-307 Chronic Kidney Disease After Heart Transplantation: Risk Factors, Clinics, and Histopathology....Pages 353-364 Front Matter....Pages 365-365 Pathology of Pediatric Heart Transplantation....Pages 367-377 Combined Heart Transplants....Pages 379-391 The Autopsy in Heart Transplantation....Pages 393-417 Examination of Native Hearts with Implantable Mechanical Circulatory Support Systems....Pages 419-425 Back Matter....Pages 427-450