The Pathobiology of Neoplasia

This book is directed primarily to advanced graduate and medical students, postdoctoral trainees, and established investigators having basic research interests in neoplasia. Its content is based in part on the lecture outlines and selected histopathology laboratory components of an advanced course entitled The Pathobiology of Experimental Animal and Human Neoplasia, developed by me for the Experimental Pathology Curriculum of the Department of Pathology at the Medical College of Virginia. In this regard, an effort has been made to integrate pathology with carcinogenesis, genetics, biochemistry, and cellular and molecular biology in order to present a comprehensive and current view of the neoplastic process. For focus, emphasis is mainly being placed on the neoplastic cells themselves, and not on associated host-mediated responses. It ishoped that this book will accomplish its purpose of providing students and researchers who already possess strong but diverse basic science backgrounds with unifying concepts in tumor pathobiology, so as to stimulate new research aimed at furthering our understanding of neoplastic disease. I wish to express my appreciation and heartfelt thanks to the authors, whose individual ranges of expertise and research experience clearly bring to their respective chapters unique perspectives that easily transcend any redundancy that may be present. In addition, I am grateful to Drs. George Vennart, Saul Kay, and Fred Meier, and to Ms. Connie Wilkerson of the Department of Pathology at MCV, for their helpful comments and their review of some of the material. Front Matter....Pages i-xxii Introduction Chronology of Significant Events in the Study of Neoplasia....Pages 1-24 Classification of Neoplasms....Pages 25-38 Chemical Carcinogenesis in Experimental Animals and Humans....Pages 39-56 DNA Adducts and Carcinogenesis....Pages 57-80 Oncogenic Viruses....Pages 81-109 Radiation Carcinogenesis....Pages 111-129 The Multistage Concept of Carcinogenesis....Pages 131-148 Organ and Species Specificity in Chemical Carcinogenesis and Tumor Promotion....Pages 149-171 DNA Repair Mechanisms and Carcinogenesis....Pages 173-197 Preneoplasia and Precancerous Lesions....Pages 199-215 Tumor Progression and the Clonal Evolution of Neoplasia....Pages 217-229 Cytogenetics and Human Neoplasia....Pages 231-246 Genetics of Susceptibility to Mouse Skin Tumor Promotion....Pages 247-274 Oncogenes....Pages 275-290 Activation of Oncogenes by Chemical Carcinogens....Pages 291-304 Alterations in Biochemical Control Mechanisms of Neoplastic Cells....Pages 305-322 Membrane Alterations in Neoplasia....Pages 323-344 Growth Factors and Neoplasia....Pages 345-370 Biochemical Mechanisms of Action of the Phorbol Ester Class of Tumor Promoters....Pages 371-383 Biochemical Marker Alterations in Hepatic Preneoplasia and Neoplasia....Pages 385-397 Oncogene Activation and Expression during Carcinogenesis in Liver and Pancreas....Pages 399-417 Oncodevelopmental Expression and Neoplasia....Pages 419-434 Expression of Differentiated Function in Neoplasms....Pages 435-460 Ectopic Hormone Production and Neoplasia....Pages 461-475 Metaplastic Transformation of Pancreatic Cells to Hepatocytes....Pages 477-495 Crown Gall Neoplasms....Pages 497-512 Angiogenesis....Pages 513-531 Tumor Invasion and Metastases....Pages 533-546 Phenotypic Heterogeneity and Metastasis....Pages 547-572 Back Matter....Pages 573-583