The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism (Proteins and Cell Regulation (6))

Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2 nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research. Paraoxonases: An Historical Perspective / C.e. Furlong -- Glucose Inactivates Paraoxonase 1 (pon1) And Displaces It From High Density Lipoprotein (hdl) To A Free Pon1 Form / M. Rosenblat [and Others] -- Paraoxonase-1 And Cardiovascular Disease / B. Mackness And M.i. Mackness -- Oxidative Stress & Antioxidants And Pon1 In Health And Disease / E. Sozmen [and Others] -- D-4f Increases Paraoxonase 1 Activity In Hdl / G. Hough -- Paraoxonase 1 (pon1), A Junction Between The Metabolisms Of Homocysteine And Lipids / H. Jakubowski -- The Role Of Pon2 And Pon3 In Atherosclerosis And Related Traits / N. Bourquard [and Others] -- Paraoxonase 1 And Postprandial Lipemia / A. Alipour [and Others] -- Pon1 Genotypes And Coronary Heart Disease / M. Roest And H.a.m. Voorbij -- Human Paraoxonase I: A Potential Bioscavenger Of Organophosphorus Nerve Agents / D. Yeung [and Others] -- Stabilisation Of Active Form Of Natural Human Pon1 Requires Hpbp / D. Rochu [and Others] -- Paraoxonase-1 In Chronic Liver Diseases, Neurological Diseases And Hiv Infection / J. Marsillach [and Others] -- Age-related Alterations In Pon1 / I. Seres [and Others] -- Paraoxonase (pon1) And Organophosphate Toxicity / L.g. Costa [and Others] -- Implications Of Paraoxonase-1 (pon1) Activity And Polymorphisms On Biochemical And Clinical Outcomes In Workers Exposed To Pesticides / A.f. Hernández [and Others] -- Transcriptional Regulation Of The Paraoxonase Genes / S.p. Deakin And R.w. James -- Effect Of Lipid Lowering Medications On Pon1 / G. Paragh [and Others] -- The Functional Consequences Of Polymorphisms In The Human Pon1 Gene / C.e. Furlong [and Others] -- Dietary Modulation Of Paraoxonase-1 Activity And Concentration In Humans / C. Dalgård -- Pons' Natural Substrates -- The Key For Their Physiological Roles / D.i. Draganov And J.f. Teiber -- Paraoxonases, Quorum Sensing, And Pseudomonas Aeruginosa / D.a. Stoltz [and Others]. Edited By Bharti Mackness ... [et Al.]. Includes Bibliographical References And Index. Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few "mad" scientists searching for "natural" substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimers and many more while remaining important in determining organophosphate toxicity. In September 2006 the 2nd International Conference on Paraoxonases took place in Hajduszoboszlo, Hungary, bringing together the worlds foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up-to-date, state-of-the-art review of current paraoxonase research Features a distillation of the plenary lectures presented at the International Conference on Paraoxonases, held in Hajduszoboszlo, Hungary, in September 2006. This book offers a review of paraoxonase research