The p53 Tumor Suppressor Pathway and Cancer (Protein Reviews, Vol. 2)

The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signi?cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world. Ch. 1. The P53 Network / Arnold J. Levine, Jill Bargonetti, Gareth L. Bond, Josephine Hoh, Kenan Onel, Michael Overholtzer, Archontoula Stoffel, Angelica K. Teresky, Christine A. Walsh And Shengkan Jin -- Chapter 2. The Three-dimensional Structure Of P53 / Elena S. Stavridi, Yentram Huyen, Emily A. Sheston And Thanos D. Halazonetis -- Chapter 3. Transcriptional Activation By P53 : Mechanisms And Targeted Genes / Timothy Maclachlan And Wafik El-deiry -- Chapter 4. Transcriptional Repression By The P53 Tumor Suppressor Protein / Jack T. Zilfou And Maureen E. Murphy -- Chapter 5. Posttranslational Modifications Of P53 : Upstream Signaling Pathways / Carl W. Anderson And Ettore Appella -- Chapter 6. P53 In Human Cancer -- Somatic And Inherited Mutations And Mutation-independent Mechanisms / Ute M. Moll And Nicole Concin -- Chapter 7. Mdm2 And Mdmx Regulators Of P53 Activity / Jamil Momand, Paul Joseph Aspuria And Saori Furuta -- Chapter 8. P53 Family Members : P63 And P73 / Elsa R. Flores And Tyler Jacks -- Chapter 9. The Oncogenic Activity Of P53 Mutants / Alex Sigal And Varda Rotter -- Chapter 10. Therapeutic Strategies Based On Pharmacological Modulation Of P53 Pathway / Andrei V. Gudkov. Edited By Gerard P. Zambetti. Includes Bibliographical References And Index. Mode Of Access: World Wide Web.