The Nociceptin/Orphanin FQ Peptide Receptor (Handbook of Experimental Pharmacology 254)

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications. Front Matter ....Pages i-x The History of N/OFQ and the NOP Receptor (Rainer K. Reinscheid, Olivier Civelli)....Pages 3-16 NOP-Targeted Peptide Ligands (Delia Preti, Girolamo Caló, Remo Guerrini)....Pages 17-36 NOP-Targeted Nonpeptide Ligands (Nurulain T. Zaveri, Michael E. Meyer)....Pages 37-67 Pharmacological Assays for Investigating the NOP Receptor (Davide Malfacini, Girolamo Caló)....Pages 69-89 Electrophysiological Actions of N/OFQ (Bryony L. Winters, Macdonald J. Christie, Christopher W. Vaughan)....Pages 91-130 NOP Receptor Signaling Cascades (Kyle E. Parker, Michael R. Bruchas)....Pages 131-139 Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor (Francesca Felicia Caputi, Patrizia Romualdi, Sanzio Candeletti)....Pages 141-162 NOP-Related Mechanisms in Pain and Analgesia (Lawrence Toll, Akihiko Ozawa, Andrea Cippitelli)....Pages 165-186 NOP-Related Mechanisms in Substance Use Disorders (Roberto Ciccocioppo, Anna Maria Borruto, Ana Domi, Koji Teshima, Nazzareno Cannella, Friedbert Weiss)....Pages 187-212 NOP Receptor Ligands and Parkinson’s Disease (Daniela Mercatelli, Clarissa Anna Pisanò, Salvatore Novello, Michele Morari)....Pages 213-232 NOP Ligands for the Treatment of Anxiety and Mood Disorders (Elaine C. Gavioli, Victor A. D. Holanda, Chiara Ruzza)....Pages 233-257 The Nociceptin/Orphanin FQ System and the Regulation of Memory (Lionel Moulédous)....Pages 259-278 N/OFQ-NOP System in Food Intake (Maria Vittoria Micioni Di Bonaventura, Emanuela Micioni Di Bonaventura, Carlo Cifani, Carlo Polidori)....Pages 279-295 N/OFQ-NOP System in Peripheral and Central Immunomodulation (Salim Kadhim, Mark F. Bird, David G. Lambert)....Pages 297-311 N/OFQ-NOP System and Airways (Bruno D’Agostino, Manuela Sgambato, Renata Esposito, Giuseppe Spaziano)....Pages 313-322 Effects of NOP-Related Ligands in Nonhuman Primates (Norikazu Kiguchi, Mei-Chuan Ko)....Pages 323-343 Nociceptin/Orphanin FQ and Urinary Bladder (Patrizia Angelico, Marco Barchielli, Massimo Lazzeri, Remo Guerrini, Girolamo Caló)....Pages 347-365 Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors (Thomas M. Tzschentke, Klaus Linz, Thomas Koch, Thomas Christoph)....Pages 367-398 Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094) (Jeffrey M. Witkin, Tanya L. Wallace, William J. Martin)....Pages 399-415 Correction to: Electrophysiological Actions of N/OFQ (Bryony L. Winters, Macdonald J. Christie, Christopher W. Vaughan)....Pages 417-417