The Neuropharmacology of Alcohol (Handbook of Experimental Pharmacology 248)

This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research. Additionally, this book covers important topics under the heading of “experimental pharmacology” and alcohol. Front Matter ....Pages i-xi Front Matter ....Pages 1-1 GABAA Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence (Cassie M. Chandler, John S. Overton, Daniela Rüedi-Bettschen, Donna M. Platt)....Pages 3-27 Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking (David M. Lovinger)....Pages 29-54 Dynamic Adaptation in Neurosteroid Networks in Response to Alcohol (Deborah A. Finn, Vanessa A. Jimenez)....Pages 55-78 GABA and Glutamate Synaptic Coadaptations to Chronic Ethanol in the Striatum (Verginia C. Cuzon Carlson)....Pages 79-112 The Cerebellar GABAAR System as a Potential Target for Treating Alcohol Use Disorder (David J. Rossi, Ben D. Richardson)....Pages 113-156 Do Alcohol-Related AMPA-Type Glutamate Receptor Adaptations Promote Intake? (F. Woodward Hopf, Regina A. Mangieri)....Pages 157-186 Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions (Paul M. Klenowski, Andrew R. Tapper)....Pages 187-212 Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure (Cody A. Siciliano, Anushree N. Karkhanis, Katherine M. Holleran, James R. Melchior, Sara R. Jones)....Pages 213-238 Central Noradrenergic Interactions with Alcohol and Regulation of Alcohol-Related Behaviors (Elena M. Vazey, Carolina R. den Hartog, David E. Moorman)....Pages 239-260 Front Matter ....Pages 261-261 Voltage-Sensitive Calcium Channels in the Brain: Relevance to Alcohol Intoxication and Withdrawal (Prosper N’Gouemo)....Pages 263-280 Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons (Alex M. Dopico, Anna N. Bukiya, Jill C. Bettinger)....Pages 281-309 Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior (Reginald Cannady, Jennifer A. Rinker, Sudarat Nimitvilai, John J. Woodward, Patrick J. Mulholland)....Pages 311-343 Front Matter ....Pages 345-345 Hepatic Immune System: Adaptations to Alcohol (Adam Kim, Rebecca L. McCullough, Kyle L. Poulsen, Carlos Sanz-Garcia, Megan Sheehan, Abram B. Stavitsky et al.)....Pages 347-367 Innate Immune Signaling and Alcohol Use Disorders (Leon G. Coleman Jr., Fulton T. Crews)....Pages 369-396 Ethanol and Cytokines in the Central Nervous System (Marisa Roberto, Reesha R. Patel, Michal Bajo)....Pages 397-431 Front Matter ....Pages 433-433 Corticotropin-Releasing Factor (CRF) Neurocircuitry and Neuropharmacology in Alcohol Drinking (Allyson L. Schreiber, Nicholas W. Gilpin)....Pages 435-471 Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol (Rachel I. Anderson, David E. Moorman, Howard C. Becker)....Pages 473-503 Transcriptional Regulators as Targets for Alcohol Pharmacotherapies (Antonia M. Savarese, Amy W. Lasek)....Pages 505-533 Front Matter ....Pages 535-535 Advancing Pharmacotherapy Development from Preclinical Animal Studies (Mark Egli)....Pages 537-578 Advances in Pharmacotherapy Development: Human Clinical Studies (Raye Z. Litten, Daniel E. Falk, Megan L. Ryan, Joanne Fertig, Lorenzo Leggio)....Pages 579-613 Correction to: GABAA Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence (Cassie M. Chandler, John S. Overton, Daniela Rüedi-Bettschen, Donna M. Platt)....Pages 615-615 Correction to: Presynaptic Ethanol Actions: Potential Roles in Ethanol Seeking (David M. Lovinger)....Pages 617-617 Correction to: Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior (Reginald Cannady, Jennifer A. Rinker, Sudarat Nimitvilai, John J. Woodward, Patrick J. Mulholland)....Pages 619-619 Correction to: Innate Immune Signaling and Alcohol Use Disorders (Leon G. Coleman Jr., Fulton T. Crews)....Pages 621-621 Correction to: Transcriptional Regulators as Targets for Alcohol Pharmacotherapies (Antonia M. Savarese, Amy W. Lasek)....Pages 623-624 Correction to: Advancing Pharmacotherapy Development from Preclinical Animal Studies (Mark Egli)....Pages 625-625