The Neurobiology of Schizophrenia

__The Neurobiology of Schizophrenia__ begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. * Provides a comprehensive overview of neurobiological aspects of schizophrenia * Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels * Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance * Elucidates connections between the various systems depicted, when possible Content: Front-matter,Copyright,List of Contributors,AcknowledgmentsEntitled to full textPart I: IntroductionChapter 1 - Historical and Clinical Overview: Implications for Schizophrenia Research, Pages 3-13, T. Nickl-Jockschat, T. Abel Chapter 2 - Progress and Prospects for Endophenotypes for Schizophrenia in the Time of Genomics, Epigenetics, Oscillatory Brain Dynamics, and the Research Domain Criteria, Pages 17-38, G.A. Miller, B.S. Rockstroh Chapter 3 - Insights From Genome-Wide Association Studies (GWAS), Pages 39-50, S. Cichon, S. Ripke Chapter 4 - Sequencing Approaches to Map Genes Linked to Schizophrenia, Pages 51-59, P.M.A. Sleiman, H. Hakonarson Chapter 5 - Epigenetic Approaches to Define the Molecular and Genetic Risk Architectures of Schizophrenia, Pages 61-82, M. Kundakovic, C. Peter, P. Roussos, S. Akbarian Chapter 6 - Exploring Neurogenomics of Schizophrenia With Allen Institute for Brain Science Resources, Pages 83-106, M. Hawrylycz, T. Nickl-Jockschat, S. Sunkin Chapter 7 - The Dopamine Hypothesis of Schizophrenia: Current Status, Pages 109-124, G. Gründer, P. Cumming Chapter 8 - The PSD: A Microdomain for Converging Molecular Abnormalities in Schizophrenia, Pages 125-147, A. Banerjee, K.E. Borgmann-Winter, R. Ray, C.-G. Hahn Chapter 9 - Targeting Cognitive Deficits in Schizophrenia via GABAA Receptors: Focus on α2, α3, and α5 Receptor Subtypes, Pages 149-164, U. Rudolph, H. Möhler Chapter 10 - Metabolomics of Schizophrenia, Pages 167-177, D. Rujescu, I. Giegling Chapter 11 - The Role of Inflammation and the Immune System in Schizophrenia, Pages 179-193, N. Müller, E. Weidinger, B. Leitner, M.J. Schwarz Chapter 12 - Proteomics of Schizophrenia, Pages 195-209, M.P. Coba Chapter 13 - EEG and MEG Probes of Schizophrenia Pathophysiology, Pages 213-236, E. Neustadter, K. Mathiak, B.I. Turetsky Chapter 14 - Cellular and Circuit Models of Increased Resting State Network Gamma Activity in Schizophrenia, Pages 237-259, R.S. White, S.J. Siegel Chapter 15 - Computational Neuroanatomy of Schizophrenia, Pages 263-282, C. Davatzikos, N. Koutsouleris Chapter 16 - Brain Computations in Schizophrenia, Pages 283-295, R.A. Adams, K.J. Friston Chapter 17 - Schizophrenia and Functional Imaging, Pages 297-312, K. Pauly, C. Moessnang Chapter 18 - Anatomical and Functional Brain Network Architecture in Schizophrenia, Pages 313-336, G. Collin, M.P. van den Heuvel Chapter 19 - Statistical Learning of the Neurobiology of Schizophrenia: Neuroimaging Meta-Analyses and Machine-Learning in Schizophrenia Research, Pages 337-350, D. Bzdok, S.B. Eickhoff Chapter 20 - Modeling Schizophrenia in Animals: Old Challenges and New Opportunities, Pages 353-381, Y. Ayhan, C.E. Terrillion, M.V. Pletnikov Chapter 21 - Behavioral Phenotypes of Genetic Mouse Models: Contributions to Understanding the Causes and Treatment of Schizophrenia, Pages 383-396, P.M. Moran Chapter 22 - Genetic Mechanisms Emerging from Mouse Models of CNV-Associated Neuropsychiatric Disorders, Pages 397-417, A. Nishi, N. Hiroi Author Index, Pages 419-432 Subject Index, Pages 433-448

The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance.

• Provides a comprehensive overview of neurobiological aspects of schizophrenia
• Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels
• Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance
• Elucidates connections between the various systems depicted, when possible

Edited By Ted Abel, Thomas Nickl-jockschat. Includes Indexes. Mode Of Access: World Wide Web.