The Natural History of Rabies, Volume 1

The Natural History of Rabies, Volume I explores the fundamental aspects of the rabies virus, including its growth, latency, morphology, chemistry, physical characteristics, and relationships with other viruses. It looks at the virus'in vivo pathogenesis and pathology, from entrance to transmission in the central nervous system (CNS) and subsequent exit. It also reviews current diagnostic methods including those used for antibody titration and for determination of virus presence. Organized into three sections encompassing 21 chapters, this volume begins with an overview of the history of rabies as well as its morphology and morphogenesis. It then discusses the virus'antigenic composition and relationships, hemagglutinin and the optimal conditions for its preparation and demonstration, advantages and disadvantages of the passive hemagglutination test, methods for concentration and purification of the virus, and growth in cell culture. It explains the virus'pathogenesis to and spread within and from the CNS, electron microscopy of CNS and extraneural rabies infection, lipotropism in rabies virus infection, use of exogenous and endogenous interferon to inhibit rabies virus infection, mouse inoculation and Negri body diagnosis, and fluorescent antibody test in rabies. The book concludes with an assessment of the serum neutralization, indirect fluorescent antibody, and rapid fluorescent focus inhibition tests. This book is a valuable resource for virologists, pathologists, epidemiologists, and students. Content: Inside Front Cover , Page ii Front Matter , Page iii Copyright , Page iv List of Contributors , Pages xi-xii Preface , Pages xiii-xiv Contents of Volume II , Pages xv-xvi CHAPTER 1 - History of Rabies , Pages 1-29 CHAPTER 2 - Morphology and Morphogenesis , Pages 33-61 CHAPTER 3 - Antigenic Composition of Rabies Virus , Pages 63-78 CHAPTER 4 - Chemical Composition and Structure of Rabies Virus , Pages 79-102 CHAPTER 5 - Hemagglutinin of Rabies Virus , Pages 103-113 CHAPTER 6 - Passive Hemagglutination Test , Pages 115-123 CHAPTER 7 - Concentration and Purification , Pages 125-140 CHAPTER 8 - Rabies Virus Antigenic Relationships , Pages 141-152 CHAPTER 9 - Growth of Rabies Virus in Cell Culture , Pages 155-179 CHAPTER 10 - Pathogenesis to the Central Nervous System , Pages 181-198 CHAPTER 11 - Spread of Virus within the Central Nervous System , Pages 199-216 CHAPTER 12 - Electron Microscopy of Central Nervous System Infection , Pages 217-233 CHAPTER 13 - The Pathology of Rabies in the Central Nervous System , Pages 235-272 CHAPTER 14 - Spread of Virus from the Central Nervous System , Pages 273-301 CHAPTER 15 - Electron Microscopy of Extraneural Rabies Infection , Pages 303-318 CHAPTER 16 - Lipotropism in Rabies Virus Infection , Pages 319-330 CHAPTER 17 - Latency and Abortive Rabies , Pages 331-354 CHAPTER 18 - Interferon and Rabies Virus Infection , Pages 355-369 CHAPTER 19 - Animal Inoculation and the Negri Body , Pages 373-374,374a,375-400 CHAPTER 20 - The Fluorescent Antibody Test in Rabies , Pages 401-410,410a,411-416 CHAPTER 21 - The Serum Neutralization, Indirect Fluorescent Antibody, and Rapid Fluorescent Focus Inhibition Tests , Pages 417-433 AUTHOR INDEX , Pages 435-449 SUBJECT INDEX , Pages 450-454