The mucosal immune system proceedings of a seminar in the EEC Programme of Coordination of Agricultural Research on Protection of the Young Animal against Perinatal Diseases, held at the University of Bristol, School of Veterinary Science, Langford, Nr. B

This publication contains the proceedings of a Seminar on 'The Mucosal Immune System' held by the Commission of the European Communities (CEC) at the University of Bristol. School of Veterinary Science. Langford. Bristol on September 9th - 11th. 1960. The seminar formed part of the CEC programme of co-ordinated agricultural research on Protection of the Young Animal against Perinatal Disease and was organised by Professor F.J. Bourne and his colleagues Dr. T.J. Newby and Dr. C.R. Stokes. The Proceedings were edited by the organisers assisted by Janssen Services. 33a High Street. Chislehurst. Kent and provide an authoritative and up-to-date account of this rapidly moving research area. Serious economic loss from diseases of mucosal surfaces - particularly the enteric and respiratory tracts - occurs in young farm animals throughout the EEC. Protection against these diseases is based on an understanding of their epidemiology including host defence mechanisms. Mucosal vaccines have in the main given disappointing field results with. however. some notable exceptions. This seminar rationalises methods used to stimulate mucosal immune defence and indicates likely areas for future research and development. The CEC wishes to thank the organisers and the participants who con­ tributed to the success of the seminar. OPENING SESSION Chairman F.J. Bourne 3 OPENING REMARKS F.J. Bourne On behalf of the University of Bristol and the European Economic Community my colleagues and I welcome you to the Langford Veterinary School. Front Matter....Pages I-IX Front Matter....Pages 1-1 Opening Remarks....Pages 3-3 Mucosal Immunity....Pages 5-27 Front Matter....Pages 29-29 Comparative Aspects of Secretory Immunity: The Transport of Heterologous IgA from Blood to Bile in Experimental Animals....Pages 31-48 Binding, Uptake and Processing of Polymeric IgA by Cultured Rat Hepatocytes....Pages 49-70 Epithelial Transport of Human Secretory Immunoglobulins....Pages 71-104 Front Matter....Pages 105-105 Induction and Expression of Mucosal Cell Mediated Immunity....Pages 107-136 Stimulation and Suppression of IgE Antibodies by Antigens Presented to Mucosal Surfaces....Pages 137-153 Food Antigen Handling and Immune Complex Formation in Healthy and Allergic Individuals....Pages 154-180 An Animal Model of Anaphylactic Peptic Ulceration — A New Approach to Ulcer Disease in Humans?....Pages 181-202 Gastrointestinal Hypersensitivity in the Preruminant Calf....Pages 203-223 Altered Immune Function Associated with Dietary Factors....Pages 224-242 Back Matter....Pages 175-180 Front Matter....Pages 257-257 Passive Immunity Against Enteric Viral Infections of Piglets....Pages 259-282 Induction of an Interferon Activity in the Nasal Mucus of Calves by Administration of Inactivated IBR Virus and Levamisole....Pages 283-292 Kinetics of Intestinal Antibody Development in Calves after Infection with Bovine Rotavirus....Pages 293-309 Immune Response to Subunit Vaccines Against Enveloped Viruses....Pages 310-329 Importance of Local Antibody in Resistance to Mycoplasma Infections of the Respiratory Tract....Pages 330-362 The Mammary Gland Immune Response and Its Relationship to Intestinal Antigenic Exposure....Pages 363-376 The Immune Response Following Oral Vaccination with E. coli ....Pages 377-388 The Role of Mucus Secretions in the Protection of the Gastrointestinal Mucosa....Pages 389-401 Mucus Secretion in the Gut, Its Relationship to the Immune Response in Nippostrongylus-Infected Rats....Pages 402-440 Front Matter....Pages 441-441 Immunoglobulin Serum Levels and Population of Intestinal IgA Plasma Cells in Normal and Immuno-Deficient (Nude — Neonatally Mu Suppressed — Neonatally Delta Suppressed) Rats....Pages 443-460 The Experimental Basis for Oral Immunisation Against Cholera....Pages 461-484 Short Communication....Pages 485-490 Short Communication....Pages 491-493 Short Communication....Pages 494-501 Summary....Pages 502-510 Front Matter....Pages 511-511 Homing of Lymphocytes after Oral Vaccination of the Sow....Pages 513-519 Immune Mechanisms in the Respiratory Tract....Pages 520-533 Changes of Systemic Hypersensitivity Due to Enterally Applied Antigen....Pages 534-544 Immune Mechanisms in the Respiratory Tract....Pages 545-555 Back Matter....Pages 556-560