The Molecular Immunology of Complex Carbohydrates-3 (Advances in Experimental Medicine and Biology Book 705)

Based on the proceedings of the third international symposium on “Molecular Immunology of Complex Carbohydrates,” this text is the latest in a series dedicated to glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. Section I of the book pays tribute to three pioneers in the field—Walter T.J. Morgan, Elvin A. Kabat and especially Winifred M. Watkins; it presents advanced concepts concerning the structure and functions of Blood group ABH/Le-related antigens, offering a comprehensive review on human blood group ABH/Ii, Le a,b,x,y and siayl Le a,x glycotopes of human ovarian cyst glycoproteins. Section II covers the interactions of plant, bacterial and animal lectins with carbohydrates and proteins. Section III describes the structures and functions of gangliosides and microbial glycolipids. Section IV covers the physiological roles of other clycocunjugates in humans, animals, sponges and bacteria as well as aging-related alterations of glycosylation profile in humans. Section V discusses the role of carbohydrates as antigens and regulators of the immune response. Section VI addresses some aspects of the glycobiology of cancer. And section VII details new methodologies in glycol-synthesis and lectin-carbohydrate binding assays and strategies for treatment as crucial applications. Based On The Proceedings Of The Third International Symposium On Molecular Immunology Of Complex Carbohydrates, This Text Is The Latest In A Series Dedicated To Glycotopes, Structures And Functions Of Complex Carbohydrates, Recognition Factors Of Lectins, Biomolecular Interactions And Other Glycosciences. Section I Of The Book Pays Tribute To Three Pioneers In The Field--walter T.j. Morgan, Elvin A. Kabat And Especially Winifred M. Watkins; It Presents Advanced Concepts Concerning The Structure And Functions Of Blood Group Abh/le-related Antigens, Offering A Comprehensive Review On Human Blood Group Abh/ii, Lea, B, X, Y And Siayl Lea, X Glycotopes Of Human Ovarian Cyst Glycoproteins. Section Ii Covers The Interactions Of Plant, Bacterial And Animal Lectins With Carbohydrates And Proteins. Section Iii Describes The Structures And Functions Of Gangliosides And Microbial Glycolipids. Section Iv Covers The Physiological Roles Of Other Clycocunjugates In Humans, Animals, Sponges And Bacteria As Well As Aging-related Alterations Of Glycosylation Profile In Humans. Section V Discusses The Role Of Carbohydrates As Antigens And Regulators Of The Immune Response. Section Vi Addresses Some Aspects Of The Glycobiology Of Cancer. And Section Vii Details New Methodologies In Glycol-synthesis And Lectin-carbohydrate Binding Assays And Strategies For Treatment As Crucial Applications.--publisher's Website. Pt. 1. Introduction To Glyco-experiences. Serendipity In Scientific Discoveries: Some Examples In Glycosciences / Yuan-chuan Lee -- My 30-year Devotion To The N-linked Oligosaccharaide Structures / Noriko Takahashi -- Pt. 2. Blood Group Abh/le-related Antigens. Human Blood Group Abh/le, Le[a], [b], [x], [y], And Sialyl Le[a], [x] Glycotopes: Internal Structures; And Immunochemical Roles Of Human Ovarian Cyst Glycoproteins / Albert M. Wu -- Lewis Glyco-epitopes: Structures, Biosynthesis, And Function / Hui-li Chen -- A Unique Endo-[beta]-galactosidase That Cleaves Both Blood Group A And B Glycotopes / Su-chen Li, Kimberly M. Anderson, And Yu-teh Li -- Pt. 3. Lectins. Recognition Roles Of Mammalian Structural Units And Polyvalency In Lectin-glycan Interactions / Albert M. Wu [and Others] -- Adhesian/growth-regulatory Galectins: Insights Into Their Ligand Selectivity Using Natural Glycoproteins And Glycotopes / Albert M. Wu [and Others] --^ Glycotope Structures And Intramolecular Affinity Factors Of Plant Lectins For Tn/t Antigens / Pierre Rougé [and Others] -- The Five Bacterial Lectins (pa-il, Pa-iil, Rsl, Rs-iil, And Cv-iil): Interactions With Diverse Animal Cells And Glycoproteins / Nechama Gilboa-garber [and Others] -- On The Differentiated Sialic Acid Specificity Of Lectins From Different Part Of Saraca Indica / Bishnu P. Chatterjee And Mainak Majumder -- Regulation Of Lectin Production By The Human Pathogens Pseudomonas Aeruginosa And Chromobacterium Violaceum: Effect Of Choline, Trehalose, And Ethanol / Nachman C. Garber [and Others] -- Non-carbohydrate-mediated Interaction Of Lectins With Plant Proteins / Jared Q. Gerlach [and Others] -- Novel Concepts About The Role Of Lectins In The Plant Cell / Els. J.m. Van Damme -- Pt. 4. Structures And Functions Of Glycolipids. Role Of Gangliosides And Plasma Membrane-associated Sialidase In The Process Of Cell Membrane Organization / Sandro Sonnino [and Others] --^ 9-o-acetyl Gd3 In Lymphoid And Erythroid Cells / Kankana Mukherjee [and Others] -- Gm3 Upregulation Of Matrix Metalloproteinase-9 Possibly Through Pi3k, Akt, Rictor, Rhogdi-2, And Tnf-a Pathways In Mouse Melanoma B16 Cells / Pu Wang [and Others] -- Pathological Roles Of Ganglioside Mimicry In Guillain-barré Syndrome And Related Neuropathies / Robert K. Yu [and Others] -- Structure And Function Of Glycolipids In Thermophilic Bacteria / Feng-ling Yang, Yu-liang Yang, And Shih-hsiung Wu -- Lipooligosaccharides Of Neisseria Species: Similarity Between N. Polysaccharea And N. Meningitidis Loss / Chao-ming Tsai -- Pt. 5. Structures And Functions Of Complex Carbohydrates. Roles For N- And O-glycans In Early Mouse Development / Suzannah A. Williams And Pamela Stanley -- Glycobiology In The Field Of Gerontology (glycogerontology) / Akira Kobata -- Galectins In Regulation Of Apoptosis / Fu-tong Liu [and Others] --^ Avian And Human Influenza Virus Receptors And Their Distribution / Yasuo Suzuki -- Importance Of A Factor Viiic-like Glycoprotein Expressed In Capillary Endothelial Cells (efactor Viiie) In Angiogenesis / Dipak K. Banerjee [and Others] -- Mucin O-glycan Branching Enzymes: Structure, Function, And Gene Regulation / Pi-wan Cheng And Prakash Radhakrishnan -- Studying Carbohydrate Self-recognition In Marine Sponges Using Synthetic Aggregation Factor Epitopes / Johannis P. Kamerling And Adriana Carvalho De Souza -- Docking Fo The Chitin Oligomers And Nod Factors On Lectin Domains Of The Lysm-rlk Receptors In The Medicago-rhizobium Symbiosis / Pierre Rougé [and Others] -- Pt. 6. Glycoimmunology. O-acetylated Sialic Acides And Their Role In Immune Defense / Roland Schauer [and Others] -- Sialylated And Sulfated Carbohydrate Ligands For Selectins And Siglecs: Involvement In Traffic And Homing Of Human Memory T And B Lymphocytes / Reiji Kannagi [and Others] --^ Diversity Of Natural Anti-[alpha]-galactosyl Antibodies In Human Serum / Elwira Lisowska And Maria Duk -- Significance Of Serum Glycoprotein Profiles In Spontaneous Tolerance After Liver Allograft Transplantation / Pei-weng Wang And Tai-long Pan -- Pt. 7. Glycobiology Of Cancer. Hematogenous Metastasis: Roles Of Cd44v And Alternative Sialofucosylated Selectin Ligands / Konstantinos Konstantopoulos And Susan N. Thomas -- Regulation Of Glycosyltransferase Genes In Apoptotic Breast Cancer Cells Induced By L-ppmp And Cisplatin / Rui Ma [and Others] -- Aberrant Glycosphingolipid Expression And Membrane Organization In Tumor Cells: Consequences On Tumor-host Interactions / Alessandro Prinetti [and Others] -- Human Kdn (deaminated Neuraminic Acid) And Its Elevated Epxression In Cancer Cells: Mechanism And Significance / Sadako Inoue [and Others] --^ Polysialic Acid Bioengineering Of Cancer And Neuronal Cells By N-acyl Sialic Acid Precursor Treatment / Robert A. Pon, Wei Zhou, And Harold J. Jennings -- Pt. 8. Glyco Applications. Synthesis Of Hemagglutinin-binding Trisaccharides / Cheng-chung Wang [and Others] -- Fabrication And Applications Of Glyconanomaterials / Po-chiao Lin, Avijit Kumar Adak, And Chun-cheng Lin -- Glycan Arrays To Decipher The Specificity Of Plant Lectins / Els J.m. Van Damme [and Others] -- Targeting C-type Lectin For The Treatment Of Flavivirus Infections / Szu-ting Chen [and Others] -- Appendix -- Index. Albert M. Wu, Editor. Molecular Immunology Of Complex Carbohydrates (micc), Which Was Held At The Institute Of Biological Chemistry (ibc), Academia Sinica, Taipei, Taiwan, 8-12 July 2007, As A Satellite Meeting Of The 19th International Glycoconjugate Organization (igo) Meeting Held 15-20 July 2007 In Cairns, Australia--pref. Includes Bibliographical References And Index. pt. 1. Introduction to glyco-experiences. Serendipity in scientific discoveries: some examples in glycosciences / Yuan-Chuan Lee My 30-year devotion to the N-linked oligosaccharaide structures / Noriko Takahashi pt. 2. Blood group ABH/Le-related antigens. Human blood group ABH/Le, Le[a],[b],[x],[y], and Sialyl Le[a],[x] glycotopes: internal structures; and immunochemical roles of human ovarian cyst glycoproteins / Albert M. Wu Lewis glyco-epitopes: structures, biosynthesis, and function / Hui-Li Chen A unique endo-[Beta]-galactosidase that cleaves both blood group A and B glycotopes / Su-Chen Li, Kimberly M. Anderson, and Yu-Teh Li pt. 3. Lectins. Recognition roles of mammalian structural units and polyvalency in lectin-glycan interactions / Albert M. Wu ... [et al.] Adhesian/growth-regulatory galectins: insights into their ligand selectivity using natural glycoproteins and glycotopes / Albert M. Wu ... [et al.] Glycotope structures and intramolecular affinity factors of plant lectins for Tn/T antigens / Pierre Rougé ... [et al.] The five bacterial lectins (PA-IL, PA-IIL, RSL, RS-IIL, and CV-IIL): interactions with diverse animal cells and glycoproteins / Nechama Gilboa-Garber ... [et al.] On the differentiated sialic acid specificity of lectins from different part of Saraca indica / Bishnu P. Chatterjee and Mainak Majumder Regulation of lectin production by the human pathogens Pseudomonas aeruginosa and Chromobacterium violaceum: effect of choline, trehalose, and ethanol / Nachman C. Garber ... [et al.] Non-carbohydrate-mediated interaction of lectins with plant proteins / Jared Q. Gerlach ... [et al.] Novel concepts about the role of lectins in the plant cell / Els. J.M. Van Damme pt. 4. Structures and functions of glycolipids. Role of gangliosides and plasma membrane-associated sialidase in the process of cell membrane organization / Sandro Sonnino ... [et al.] 9-O-acetyl GD3 in lymphoid and erythroid cells / Kankana Mukherjee ... [et al.] GM3 upregulation of matrix metalloproteinase-9 possibly through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A pathways in mouse melanoma B16 cells / Pu Wang ... [et al.] Pathological roles of ganglioside mimicry in Guillain-Barré syndrome and related neuropathies / Robert K. Yu ... [et al.] Structure and function of glycolipids in thermophilic bacteria / Feng-Ling Yang, Yu-Liang Yang, and Shih-Hsiung Wu Lipooligosaccharides of Neisseria species: similarity between N. polysaccharea and N. meningitidis LOSs / Chao-Ming Tsai pt. 5. Structures and functions of complex carbohydrates. Roles for N- and O-glycans in early mouse development / Suzannah A. Williams and Pamela Stanley Glycobiology in the field of gerontology (glycogerontology) / Akira Kobata Galectins in regulation of apoptosis / Fu-Tong Liu ... [et al.] Avian and human influenza virus receptors and their distribution / Yasuo Suzuki Importance of a factor VIIIc-like glycoprotein expressed in capillary endothelial cells (eFactor VIIIe) in angiogenesis / Dipak K. Banerjee ... [et al.] Mucin O-glycan branching enzymes: structure, function, and gene regulation / Pi-Wan Cheng and Prakash Radhakrishnan Studying carbohydrate self-recognition in marine sponges using synthetic aggregation factor epitopes / Johannis P. Kamerling and Adriana Carvalho de Souza Docking fo the chitin oligomers and nod factors on lectin domains of the LysM-RLK receptors in the Medicago-Rhizobium symbiosis / Pierre Rougé ... [et al.] pt. 6. Glycoimmunology. O-acetylated sialic acides and their role in immune defense / Roland Schauer ... [et al.] Sialylated and sulfated carbohydrate ligands for selectins and siglecs: involvement in traffic and homing of human memory T and B lymphocytes / Reiji Kannagi ... [et al.] Diversity of natural anti-[alpha]-galactosyl antibodies in human serum / Elwira Lisowska and Maria Duk Significance of serum glycoprotein profiles in spontaneous tolerance after liver allograft transplantation / Pei-Weng Wang and Tai-Long Pan pt. 7. Glycobiology of cancer. Hematogenous metastasis: roles of CD44v and alternative sialofucosylated selectin ligands / Konstantinos Konstantopoulos and Susan N. Thomas Regulation of glycosyltransferase genes in apoptotic breast cancer cells induced by L-PPMP and cisplatin / Rui Ma ... [et al.] Aberrant glycosphingolipid expression and membrane organization in tumor cells: consequences on tumor-host interactions / Alessandro Prinetti ... [et al.] Human KDN (deaminated neuraminic acid) and its elevated epxression in cancer cells: mechanism and significance / Sadako Inoue ... [et al.] Polysialic acid bioengineering of cancer and neuronal cells by N-acyl sialic acid precursor treatment / Robert A. Pon, Wei Zhou, and Harold J. Jennings pt. 8. Glyco applications. Synthesis of hemagglutinin-binding trisaccharides / Cheng-Chung Wang ... [et al.] Fabrication and applications of glyconanomaterials / Po-Chiao Lin, Avijit Kumar Adak, and Chun-Cheng Lin Glycan arrays to decipher the specificity of plant lectins / Els J.M. Van Damme ... [et al.] Targeting c-type lectin for the treatment of flavivirus infections / Szu-Ting Chen ... [et al.] Appendix Index. Front Matter....Pages i-xxxv Front Matter....Pages 1-1 Serendipity in Scientific Discoveries: Some Examples in Glycosciences....Pages 3-14 My 30-Year Devotion to the N -Linked Oligosaccharide Structures....Pages 15-29 Front Matter....Pages 31-31 Human Blood Group ABH/Ii, Le a,b,x,y , and Sialyl Le a,x Glycotopes; Internal Structures; and Immunochemical Roles of Human Ovarian Cyst Glycoproteins....Pages 33-51 Lewis Glyco-Epitopes: Structure, Biosynthesis, and Functions....Pages 53-80 A Unique Endo-β-Galactosidase that Cleaves Both Blood Group A and B Glycotopes....Pages 81-95 Front Matter....Pages 97-97 Recognition Roles of Mammalian Structural Units and Polyvalency in Lectin–Glycan Interactions....Pages 99-116 Adhesion/Growth-Regulatory Galectins: Insights into Their Ligand Selectivity Using Natural Glycoproteins and Glycotopes....Pages 117-141 Glycotope Structures and Intramolecular Affinity Factors of Plant Lectins for Tn/T Antigens....Pages 143-154 The Five Bacterial Lectins (PA-IL, PA-IIL, RSL, RS-IIL, and CV-IIL): Interactions with Diverse Animal Cells and Glycoproteins....Pages 155-211 On the Differential Sialic Acid Specificity of Lectins from Different Parts of Saraca indica ....Pages 213-228 Regulation of Lectin Production by the Human Pathogens Pseudomonas aeruginosa and Chromobacterium violaceum : Effects of Choline, Trehalose, and Ethanol....Pages 229-256 Non-carbohydrate-Mediated Interaction of Lectins with Plant Proteins....Pages 257-269 Novel Concepts About the Role of Lectins in the Plant Cell....Pages 271-294 Front Matter....Pages 295-295 Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization....Pages 297-316 9- O -Acetyl GD3 in Lymphoid and Erythroid Cells....Pages 317-334 GM3 Upregulation of Matrix Metalloproteinase-9 Possibly Through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A Pathways in Mouse Melanoma B16 Cells....Pages 335-348 Pathological Roles of Ganglioside Mimicry in Guillain–Barré Syndrome and Related Neuropathies....Pages 349-365 Structure and Function of Glycolipids in Thermophilic Bacteria....Pages 367-380 Lipooligosaccharides of Neisseria Species: Similarity Between N. polysaccharea and N. meningitidis LOSs....Pages 381-394 Front Matter....Pages 395-395 Roles for N - and O -Glycans in Early Mouse Development....Pages 397-410 Front Matter....Pages 395-395 Glycobiology in the Field of Gerontology (Glycogerontology)....Pages 411-429 Galectins in Regulation of Apoptosis....Pages 431-442 Avian and Human Influenza Virus Receptors and Their Distribution....Pages 443-452 Importance of a Factor VIIIc-Like Glycoprotein Expressed in Capillary Endothelial Cells (eFactor VIIIc) in Angiogenesis....Pages 453-464 Mucin O- Glycan Branching Enzymes: Structure, Function, and Gene Regulation....Pages 465-492 Studying Carbohydrate Self-Recognition in Marine Sponges Using Synthetic Aggregation Factor Epitopes....Pages 493-510 Docking of Chitin Oligomers and Nod Factors on Lectin Domains of the LysM-RLK Receptors in the Medicago-Rhizobium Symbiosis....Pages 511-521 Front Matter....Pages 523-523 O -Acetylated Sialic Acids and Their Role in Immune Defense....Pages 525-548 Sialylated and Sulfated Carbohydrate Ligands for Selectins and Siglecs: Involvement in Traffic and Homing of Human Memory T and B Lymphocytes....Pages 549-569 Diversity of Natural Anti-α-Galactosyl Antibodies in Human Serum....Pages 571-583 Significance of Serum Glycoprotein Profiles in Spontaneous Tolerance After Liver Allograft Transplantation....Pages 585-598 Front Matter....Pages 599-599 Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands....Pages 601-619 Regulation of Glycosyltransferase Genes in Apoptotic Breast Cancer Cells Induced by l -PPMP and Cisplatin....Pages 621-642 Aberrant Glycosphingolipid Expression and Membrane Organization in Tumor Cells: Consequences on Tumor–Host Interactions....Pages 643-667 Human KDN (Deaminated Neuraminic Acid) and Its Elevated Expression in Cancer Cells: Mechanism and Significance....Pages 669-678 Polysialic Acid Bioengineering of Cancer and Neuronal Cells by N -Acyl Sialic Acid Precursor Treatment....Pages 679-688 Front Matter....Pages 689-689 Synthesis of Hemagglutinin-Binding Trisaccharides....Pages 691-726 Fabrication and Applications of Glyconanomaterials....Pages 727-755 Glycan Arrays to Decipher the Specificity of Plant Lectins....Pages 757-767 Targeting C-Type Lectin for the Treatment of Flavivirus Infections....Pages 769-776 Back Matter....Pages 777-809 Based on the third symposium on “Molecular Immunology of Complex Carbohydrates,” this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.