The molecular basis of electron transport : proceedings of the Miami Winter Symposia, January 13-14, 1972, organized by the Papanicolaou Cancer Research Institute, Miami, Florida

The Molecular Basis of Electron Transport presents the proceedings of the Miami Winter Symposia, held in Miami, Florida, on January 13–14, 1972. This book focuses on the development of the mitochondrial electron transport system by a symbiotic relationship of some bacteria with the cell. Comprised of 15 chapters, this volume starts with an overview of the structure and function of mitochondria. This book then explains all of the major categories of mitochondrial phenomena and provides the detailed molecular mechanism for mitochondrial energy coupling. Other chapters discuss the five postulates of the electromechanochemical model, including the super molecule concept, the principle of electromechanochemical energy transduction, conformon coupling, field-induced generation of the linkage system, and the de facto unit of mitochondrial control. Finally, the reader is introduced to the liver microsomal enzyme system, which catalyzes the hydroxylation of a variety of drugs, hydrocarbons, and fatty acids. Biologists, molecular biologists, and biochemists will find this book extremely useful. Content: Front Matter , Page iii Copyright , Page iv SPEAKERS, CHAIRMEN, AND DISCUSSANTS , Pages vii-ix PREFACE , Page xi , J. Schultz, B.F. Cameron THE ELECTROMECHANOCHEMICAL MODEL OF MITOCHONDRIAL STRUCTURE AND FUNCTION , Pages 1-44 , D.E. Green, S. Ji RECONSTITUTION OF OXIDATIVE PHOSPHORYLATION , Pages 45-64 , E. Racker KINETIC, THERMODYNAMIC AND COMPUTER SIMULATION STUDIES OF SITE III ELECTRON TRANSPORT AND ENERGY COUPLING AS STUDIED AT NORMAL AND SUBZERO TEMPERATURES , Pages 65-94 , Britton Chance THE RESPIRATORY CHAIN AND OXIDATIVE PHOSPHORYLATION , Pages 95-117 , E.C. SLATER EXTRAMITOCHONDRIAL REGULATION OF MITOCHONDRIAL ENERGY-COUPLED PROCESSES BY A CYTOPLASMIC FACTOR , Pages 119-132 , E. KUN, N.M. LEE, D.C. LIN, I. WIEDEMANN, K.L. JOHNSON, R.J. DUMMEL THE COUPLING OF CA 2+ TRANSPORT TO ELECTRON TRANSPORT IN MITOCHONDRIA , Pages 133-151 , ALBERT L. LEHNINGER CYTOCHROME c STRUCTURE AND REACTION MECHANISMS , Pages 153-177 , E. MARGOLIASH, R.E. DICKERSON, A.D. ADLER COMPONENT DYNAMICS IN OXYGEN REDUCTION BY CYTOCHROME P450 cam , Pages 179-196 , I.C. Gunsalus, J.D. Lipscomb CYTOCHROME P-450 - PANACEA OR PLAGUE , Pages 197-230 , R.W. Estabrook, J. Baron, M. Franklin, I. Mason, M. Waterman, J. Peterson ON THE MECHANISM OF HYDROXYLATION REACTIONS IN A RECONSTITUTED LIVER MICROSOMAL ENZYME SYSTEM CONTAINING CYTOCHROME P-450 , Pages 231-250 , M.J. Coon, H.W. Strobel, J.K. Heidema, R.M. Kaschnitz, A.P. Autor, D.P. Ballou ELECTRON TRANSPORT IN A FLAVOPROTEIN, ORCINOL HYDROXYLASE , Pages 251-274 , D.W. RIBBONS, Y. OHTA, I.J. HIGGINS RELATIONSHIP OF METABOLISM TO FUNCTION IN THE POLYMORPHONUCLEAR LEUKOCYTE, , Pages 275-300 , S.J. KLEBANOFF CHEMICAL NATURE AND BIOLOGICAL ACTIVITY OF MYELOPEROXIDASE , Pages 301-325 , J. SCHULTZ, H. SNYDER, N-C. WU, N. BERGER, M.J. BONNER THE USE OF PEROXIDASE CATALYZED REACTIONS AS A MOLECULAR AND MACROMOLECULAR PROBE , Pages 327-345 , Martin Morrison, Ronald E. Gates CHEMICAL NATURE AND REACTION OF CHLOROPEROXIDASE COMPOUND I , Pages 347-368 , LOWELL P. HAGER, DENNIS DOUBEK, PAUL HOLLENBERG