The metastatic spread of cancer : reflections upon its mechanisms based on the malignant glioma model

Association of viruses with gliomas Growth factors and oncogenes in gliomas The suppression of neoplasia 6 The Genetic Instability of Neoplasms Genomic rearrangements in cancer Transposable elements in deoxyribonucleic acid Transposable elements and viral transformation Chromosomal translocations in cancer Genetic instability assessed by premature chromosome condensation Genetic instability visualised in sister chromatid exchanges Deoxyribonucleic acid strand breaks and their repair in relation to metastasis 7 The Generation of the Metastatic Phenotype Genetic variability and evolution of diversity Estimation of rates of generation of variants by fluctuation analysis Mutation rates in metastasising and non-metastasising cell lines Deoxyribonucleic acid rearrangement in the generation of the metastatic phenotype Metastasis genes 8 Epilogue Front Matter....Pages i-xiii Front Matter....Pages 1-1 Introduction....Pages 3-3 The Intrinsic Malignancy of Gliomas....Pages 4-24 The Metastatic Cascade....Pages 25-65 Front Matter....Pages 67-67 The Heterogeneity of Tumours....Pages 69-80 Oncogenes in Tumour Development and Metastasis....Pages 81-122 The Genetic Instability of Neoplasms....Pages 123-137 The Generation of the Metastatic Phenotype....Pages 138-148 Epilogue....Pages 149-150 Back Matter....Pages 151-214