The mammalian mitochondrial respiratory chain : [by] Walter W. Wainio, with a contribution by Alice A. Greene

The Mammalian Mitochondrial Respiratory Chain provides the vocabulary related to the mitochondrial respiratory chain in mammalian species. It explores the heterogeneous nature of mitochondria, the mammalian mitochondrial cytochromes, the concept of a respiratory chain for the oxidation of substrates, the cytochrome and non-cytochrome components of the chain, and the role of the respiratory chain in energy conservation. Organized into five chapters, this volume begins with an overview of the structure and composition of mitochondria in heart, liver, kidney, and brain before turning to the NADH oxidase system and its ability to generate one additional high-energy bond for every pair of electrons transferred compared to the succinate oxidase system. It also describes electron transfer in the respiratory chain and inhibitors of the respiratory chain such as antimycin A, along with differences in the pathways of electrons from succinate, choline, and NADH to oxygen as well as systems mediated by electron-transferring flavoprotein. The reader is also introduced to the processes involved in the fragmentation, extraction, and recombination of mitochondria; artificial electron acceptors such as phenazine methosulfate and artificial electron donors such as ascorbate and tetramethyl-p-phenylenediamine; and the role of flavoproteins, including flavin mononucleotide and flavin adenine dinucleotide, in electron transport. The book concludes with a chapter that explains how the oxidation-reductions of the respiratory chain release energy in discrete packets. Graduate students and beginning researchers in biology will find this book extremely helpful. Content: Molecular Biology: An International Series of Monographs and Textbooks , Page ii Front Matter , Page iii Copyright , Page iv PREFACE , Pages vii-viii Chapter 1 - MITOCHONDRIAL STRUCTURE AND COMPOSITION , Pages 1-76 Chapter 2 - THE RESPIRATORY CHAIN , Pages 77-151 Chapter 3 - NONCYTOCHROME COMPONENTS OF THE CHAIN , Pages 152-232 Chapter 4 - CYTOCHROME COMPONENTS OF THE CHAIN , Pages 233-330 Chapter 5 - ENERGY CONSERVATION , Pages 331-391 A RECAPITULATION AND LATER DEVELOPMENTS , Pages 392-409 REFERENCES , Pages 410-458 Author Index , Pages 459-487 Subject Index , Pages 488-499