The Liver in Biology and Disease: Liver Biology in Disease, Hepato - Biology in Disease (Volume 15) (Principles of Medical Biology, Volume 15)

The Liver in Biology and Disease was conceived as a sequel in the series Principles of Medical Biology, whose general aim continues to be the integration of human biology and molecular cell biology into modern molecular medicine. It is a volume molded by the Information Revolution which few will deny has forced the teaching faculties in our medical schools to curtail and prune the teaching load and focus on fundamentals and principles. With this intention in mind, a volume of this nature takes into account the close dependence of progress in the medical sciences on bioinformatics (gene and protein analysis) or more precisely, computational biology and of course, the Internet. In general, it follows the pattern of its predecessors. *Chapters are illustrated with numerous figures and references are current*Clear, concise and accurate text about a large number of liver diseases*Describes the liver's histology, biochemistry, and pathology in molecular terms Content: 1. THE INTRAHEPATIC BILIARY TREE Review Article Pages 1-20 James M. Crawford 2. FUNCTIONAL HETEROGENEITY OF INTRAHEPATIC CHOLANGIOCYTES Review Article Pages 21-48 Gene D. LeSage, Shannon S. Glaser, Heather Francis, Jo Lynne Phinizy, Gianfranco Alpini 3. THE ACTIN CYTOSKELETON IN LIVER FUNCTION Review Article Pages 49-79 R.Brian Doctor, Matthew Nichols 4. MECHANISMS OF BILE FORMATION AND CHOLESTASIS Review Article Pages 81-118 M.Sawkat Anwer 5. THE ROLE OF BILE ACIDS IN THE MODULATION OF APOPTOSIS Review Article Pages 119-145 Cecı́lia M.P. Rodrigues, Rui E. Castro, Clifford J. Steer 6. GROWTH FACTORS AND THE LIVER Review Article Pages 147-166 Clare Selden 7. CHEMOKINE AND CYTOKINE REGULATION OF LIVER INJURY Review Article Pages 167-205 Kenneth J. Simpson, Neil C. Henderson 8. DRUG METABOLISM AND HEPATOTOXICITY Review Article Pages 207-228 J.Michael Tredger 9. ASSEMBLY AND SECRETION OF HEPATIC VERY-LOW-DENSITY LIPOPROTEIN Review Article Pages 229-256 Geoffrey Gibbons 10. BILIRUBIN METABOLISM Review Article Pages 257-289 Peter L.M. Jansen, E.Edward Bittar 11.CLINICAL BIOCHEMISTRY OF THE LIVER Review Article Pages 291-316 Neil McIntyre 12. ALCOHOLIC LIVER DISEASE Review Article Pages 317-359 S.F. Stewart, C.P. Day 13. FULMINANT HEPATIC FAILURE Review Article Pages 361-382 Watson Ng, Ian D. Norton, D.Brian Jones 14. PRIMARY BILIARY CIRRHOSIS Review Article Pages 383-398 James Neuberger 15. CHRONIC ACTIVE HEPATITIS Review Article Pages 399-425 Ian G. McFarlane 16. HEPATITIS B VIRUS Review Article Pages 427-438 F.Fred Poordad 17. CURRENT ISSUES IN HEPATITIS B VACCINES Review Article Pages 439-453 Jane N. Zuckerman, Arie J. Zuckerman 18. THE MOLECULAR VIROLOGY OF HEPATITIS C VIRUS Review Article Pages 455-495 Timothy L. Tellinghuisen, Charles M. Rice 19. THE ROLE OF THE HEPATIC STELLATE CELL IN LIVER FIBROSIS Review Article Pages 497-523 Timothy J. Kendall, John P. Iredale 20. ORTHOTOPIC LIVER TRANSPLANTATION Review Article Pages 525-542 Gagandeep Singh, Pankaj Rajvanshi, Sanjeev Gupta 21.BIOLOGICAL PRINCIPLES AND NOVEL THERAPIES IN LIVER CELL TRANSPLANTATION Review Article Pages 543-554 Sanjeev Gupta, Mari Inada, Vinay Kumaran, Brigid Joseph 22. FLUID TRANSPORT IN THE GALLBLADDER Review Article Pages 555-575 Joar Svanvik, Bengt Nilsson Author Index Pages 577-593 Contents Pages V-VII List of Contributors Pages IX-XII PREFACE Pages XIII-XVII E.Edward Bittar The Liver in Biology and Disease was conceived as a sequel in the series Principles of Medical Biology, whose general aim continues to be the integration of human biology and molecular cell biology into modern molecular medicine. It is a volume molded by the Information Revolution which few, I think, will deny has forced the teaching faculties in our medical schools to curtail and prune the teaching load and focus on fundamentals and principles. With this intention in mind, a volume of this nature takes into account the close dependence of progress in the medical sciences on bioinformatics (gene and protein analysis) or more precisely, computational biology and ofcourse, the Internet. In general, it follows the pattern of its predecessors.By strict economy, it has been found possible to deal with the main fundamentals and principles of hepatology. What can be said with certainty is that encyclopedic works and large textbooks are too vast to assimilate, although they are valuable for purposes of reference and to keep fully abreast of the myriad of advances in biotechnology. Wirtten primarily for medical students, hepatologists, predoctoral and postdoctoral graduates in the basic medical sciences, laboratory scientists, postdoctoral physicians, graduates in the allied sciences, and physicians in critical care medicine, the authors of each chapter are recognized as stellar experts in their own field. Key topics include the intrahepatic biliary tree, functional heterogeneity of the intrahepatic cholangiocytes, the actin cytoskeleton in liver function, the role of bile acids in the modulation of apoptosis, chemokines and cytokine regulation of liver injury, drug metabolism and hepatoxicity, assembly and secretion of hepatic very low density lipoprotein, bilirubin metabolism, alcoholic liver disease, chronic active hepatitis, the molecular virology of hepatitis c virus, the role of the hepatic stellate cell in liver fibrosis and orthotopic liver transplantation. The chapters are illustrated with numerous figures and the references are current. The Liver in Biology and Disease was conceived as a sequel in the series Principles of Medical Biology, whose general aim continues to be the integration of human biology and molecular cell biology into modern molecular medicine. It is a volume molded by the Information Revolution which few will deny has forced the teaching faculties in our medical schools to curtail and prune the teaching load and focus on fundamentals and principles. With this intention in mind, a volume of this nature takes into account the close dependence of progress in the medical sciences on bioinformatics (gene and protein analysis) or more precisely, computational biology and of course, the Internet. In general, it follows the pattern of its predecessors.

*Chapters are illustrated with numerous figures and references are current
*Clear, concise and accurate text about a large number of liver diseases
*Describes the liver's histology, biochemistry, and pathology in molecular terms The Liver in Biology and Disease was conceived as a sequel in the series "Principles of Medical Biology," whose general aim continues to be the integration of human biology and molecular cell biology into modern molecular medicine. It is a volume molded by the Information Revolution which few will deny has forced the teaching faculties in our medical schools to curtail and prune the teaching load and focus on fundamentals and principles. With this intention in mind, a volume of this nature takes into account the close dependence of progress in the medical sciences on bioinformatics (gene and protein analysis) or more precisely, computational biology and of course, the Internet. In general, it follows the pattern of its predecessors. *Chapters are illustrated with numerous figures and references are current *Clear, concise and accurate text about a large number of liver diseases *Describes the liver's histology, biochemistry, and pathology in molecular terms