The Kidney and Hypertension in Diabetes Mellitus, Sixth Edition

This new edition focuses on pressure-induced and metabolic related aberration, in relation to genetic abnormalities, and also changes developing in fetal life. New chapters explore exercise, lipidemia, and retinopathy in diabetic renal disease. In addition, new data are presented regarding structural changes in NIDDM-patients and the comparison of diabetic and non-diabetic renal disease. The book covers new guidelines and definitions in type 2 diabetes, management of end-stage renal failure, and demographic trends in the patient population. Other topics include diabetic nephropathy, glycemic control, and early treatment in normotensive patients with microalbuminuria with ACE-inhibitors. BOOK COVER......Page 1 TITILE......Page 4 COPYRIGHT......Page 5 CONTENTS......Page 6 PREFACE to the first edition......Page 10 PREFACE to the second edition......Page 12 PREFACE to the third edition......Page 14 PREFACE to the fourth edition......Page 15 PREFACE to the fifth edition......Page 16 PREFACE to the sixth edition......Page 17 Contributors......Page 18 1 RATIONALE FOR EARLY SCREENING FOR DIABETIC KIDNEY DISEASE......Page 24 2 PRESSURE-INDUCED AND METABOLIC ALTERATIONS IN THE GLOMERULUS: CYTOSKELETAL CHANGES......Page 36 3 THE STENO HYPOTHESIS FOR CARDIOVASCULAR AND RENAL DISEASE REVISITED......Page 50 4 MICROALBUMINURIA AND CARDIOVASCULAR DISEASE......Page 68 5 THE HEART IN DIABETES: RESULTS OF TRIALS......Page 86 6 MICROALBUMINURIA AND GFR IN TYPE 1 AND TYPE 2 DIABETES......Page 100 7 SERUM CREATININE AND OTHER MEASURES OF GFR IN DIABETES......Page 130 8 FAMILIAL FACTORS IN DIABETIC NEPHROPATHY......Page 140 9 GENETICS AND DIABETIC NEPHROPATHY......Page 152 10 LOW BIRTH WEIGHT AND DIABETIC NEPHROPATHY......Page 172 11 EFFECTS OF INSULIN ON THE CARDIOVASCULAR SYSTEM AND THE KIDNEY......Page 186 12 VALUE OF SCREENING FOR MICROALBUMINURIA IN PATIENTS WITH DIABETES MELLITUS AS WELL AS IN THE GENERAL POPULATION......Page 204 13 DYSFUNCTION OF THE VASCULAR ENDOTHELIUM AND THE DEVELOPMENT OF RENAL AND VASCULAR COMPLICATIONS IN DIABETES......Page 220 14 PATHOGENESIS AND MANAGEMENT OF BACTERIAL URINARY TRACT INFECTIONS IN ADULT PATIENTS WITH DIABETES MELLITUS......Page 246 15 PATHOLOGY OF THE KIDNEY IN DIABETES MELLITUS......Page 264 16 RENAL STRUCTURAL CHANGES IN PATIENTS WITH TYPE 1 DIABETES AND MICROALBUMINURIA......Page 278 17 RENAL STRUCTURE IN TYPE 2 DIABETES......Page 294 18 NEPHROPATHY IN TYPE 2 DIABETIC PATIENTS, PREDICTORS OF OUTCOME......Page 310 19 ADVANCED GLYCATION END-PRODUCTS AND DIABETIC RENAL DISEASE......Page 326 20 PROTEIN KINASE C ACTIVATION AND ITS INHIBITION FOR THE TREATMENT OF DIABETIC RENAL PATHOLOGIES......Page 346 21 BIOCHEMICAL ASPECTS OF DIABETIC NEPHROPATHY......Page 364 22 PATHOGENESIS OF DIABETIC GLOMERULOPATHY: THE ROLE OF GLOMERULAR HEMODYNAMIC FACTORS......Page 386 23 THE EMERGING ROLE OF GROWTH HORMONE (GH) AND VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) IN DIABETIC KIDNEY DISEASE......Page 406 24 TRANSFORMING GROWTH FACTOR-β AND OTHER CYTOKINES IN EXPERIMENTAL AND HUMAN DIABETIC NEPHROPATHY......Page 420 25 BLOOD PRESSURE ELEVATION IN DIABETES: THE RESULTS FROM 24-h AMBULATORY BLOOD PRESSURE RECORDINGS......Page 456 26 MICROALBUMINURIA IN YOUNG PATIENTS WITH TYPE 1 DIABETES......Page 480 27 EARLY RENAL HYPERFUNCTION AND HYPERTROPHY IN IDDM, INCLUDING COMMENTS ON EARLY INTERVENTION......Page 502 28 AUTOREGULATION OF GLOMERULAR FILTRATION RATE IN PATIENTS WITH DIABETES......Page 518 29 THE ROLE OF RENAL BIOPSY IN THE CLINIC......Page 538 30 INHIBITION OF THE RENIN ANGIOTENSIN ALDOSTERONE SYSTEM, WITH PARTICULAR REFERENCE TO THE DUAL BLOCKADE PRINCIPLE......Page 550 31 THE CONCEPT OF INCIPIENT DIABETIC NEPHROPATHY AND THE EFFECT OF EARLY ANTIHYPERTENSIVE INTERVENTION......Page 564 32 THE ROLE OF PROTEINURIA IN THE DIAGNOSIS AND TREATMENT OF TYPE 2 DIABETES......Page 578 33 ANTIHYPERTENSIVE TREATMENT IN TYPE 2 DIABETES, WITH SPECIAL REFERENCE TO ABNORMAL ALBUMINURIA: A FOCUS ON THE NEW TRIALS......Page 602 34 BLOOD PRESSURE LOWERING TREATMENT AND THE PREVENTION OF STROKE IN THE DIABETIC PATIENT......Page 634 35 NON-GLYCAEMIC INTERVENTION IN DIABETIC NEPHROPATHY: THE ROLE OF DIETARY PROTEIN AND SALT INTAKE......Page 654 36 DIABETIC NEPHROPATHY AND PREGNANCY......Page 670 37 EVOLUTION WORLDWIDE OF RENAL REPLACEMENT THERAPY IN DIABETES......Page 710 38 HEMODIALYSIS AND CAPD IN TYPE 1 AND TYPE 2 DIABETIC PATIENTS WITH ENDSTAGE RENAL FAILURE......Page 726 39 KIDNEY AND PANCREAS TRANSPLANTS IN DIABETES......Page 748 40 COMBINATION THERAPY FOR HYPERTENSION AND RENAL DISEASE IN DIABETES......Page 790 41 MICROALBUMINURIA IN ESSENTIAL HYPERTENSION: CARDIOVASCULAR AND RENAL IMPLICATIONS......Page 808 42 A COMPARISON OF PROGRESSION IN DIABETIC AND NON-DIABETIC RENAL DISEASE: SIMILARITY OF PROGRESSION PROMOTERS......Page 824 43 SCIENTIFIC BASIS FOR NEW GUIDELINES FOR THE TREATMENT OF HYPERTENSION IN TYPE 2 DIABETES......Page 844 44 REGULATORY CONSIDERATIONS IN THE DEVELOPMENT OF THERAPIES FOR DIABETIC NEPHROPATHY AND RELATED CONDITIONS......Page 860 45 DIABETES, HYPERTENSION,AND KIDNEY DISEASE IN THE PIMA INDIANS.......Page 880 46 THE DEVELOPMENT AND PROGRESSION OF CLINICAL NEPHROPATHY IN WHITE PATIENTS WITH TYPE 2 DIABETES......Page 894 47 MICROALBUMINURIA, BLOOD PRESSURE AND DIABETIC RENAL DISEASE: ORIGIN AND DEVELOPMENT OF IDEAS......Page 906 Now in its sixth edition, The Kidney and Hypertension in Diabetes Mellitus retains its position as the comprehensive resource for information on diabetic kidney disease. The book covers all aspects of renal involvement in diabetes and incorporates information from important publications and new trials conducted during the last three years. The new