The Kidney and Hypertension in Diabetes Mellitus

The Kidney and Hypertension in Diabetes mellitus, Third Edition endeavors to cover all aspects of renal involvement in diabetes. It is written by colleagues who are themselves active in the many fields of medical research covered in this volume: epidemiology, physiology and pathophysiology, laboratory methodology and renal pathology. This new edition focuses on pressure-induced and metabolic related aberration, in relation to genetic abnormalities, and also changes developing in fetal life. New chapters also include exercise, lipidemia, and retinopathy in diabetic renal disease. In addition, new data are included regarding structural changes in NIDDM-patients and the comparison of diabetic and non-diabetic renal disease. Front Matter....Pages i-xxvii The Nature of the Glomerulus: Pressure-Induced and Metabolic Aberrations....Pages 1-9 Definition of Diabetic Renal Disease in Insulin-Dependent Diabetes Mellitus Based on Renal Function Tests....Pages 11-22 Albuminuria in Non-Insulin-Dependent Diabetes — Renal or Extrarenal Disease?....Pages 23-34 Familial Factors in Diabetic Nephropathy....Pages 35-43 Genetics and Diabetic Nephropathy....Pages 45-52 The Concept of Birth Weight and Renal Disease....Pages 53-59 Hypertension, Cardiovascular Disease, Diabetes Mellitus, and Diabetic Nephropathy: Role of Insulin Resistance....Pages 61-74 Diabetes, Hypertension, and Kidney Disease in the Pima Indians....Pages 75-84 Value of Screening for Microalbuminuria in Diabetes as Well as in the Population....Pages 85-95 Economic Evaluations of Strategies for Preventing Renal Disease in Non-Insulin Dependent Diabetes Mellitus....Pages 97-105 Incidence of Nephropathy in Insulin-Dependent Diabetes Mellitus as Related to Mortality and Cost-Benefit of Early Intervention....Pages 107-115 Measurement of Albumin and other Urinary Proteins in Low Concentration in Diabetes Mellitus: Techniques and Clinical Significance....Pages 117-126 Office Tests for Microalbuminuria....Pages 127-134 Exercise and the Kidney in Diabetes....Pages 135-142 Clinical Course of Renal Disease in Caucasian NIDDM-Patients....Pages 143-153 Von Willebrand Factor, Dysfunction of the Vascular Endothelium, and the Development of Renal and Vascular Complications in Diabetes....Pages 155-163 Smoking and Diabetic Nephropathy....Pages 165-172 Light Microscopy of Diabetic Glomerulopathy: The Classic Lesions....Pages 173-183 Haematuria and Diabetic Nephropathy....Pages 185-193 Glomerular Ultrastructural Changes in Microalbuminuric IDDM-Patients....Pages 195-204 Renal Structure in Non Insulin-Dependent Diabetic Patients with Microalbuminuria....Pages 205-214 Sodium-Hydrogen Antiport, Cell Function and Susceptibility to Diabetic Nephropathy....Pages 215-222 Biochemical Aspects of Diabetic Nephropathy....Pages 223-233 The Steno Hypothesis and Glomerular Basement Membrane Biochemistry in Diabetic Nephropathy....Pages 235-243 Volume Homeostasis and Blood Pressure in Diabetic States....Pages 245-251 Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors....Pages 253-261 The Role of Growth Factors in Diabetic Kidney Disease....Pages 263-270 Blood Pressure Elevation in Diabetes: The Results from 24-h Ambulatory Blood Pressure Recordings....Pages 271-288 Insulin and Blood Pressure....Pages 289-297 Retinopathy in Relation to Albuminuria and Blood Pressure in IDDM....Pages 299-305 Lipidaemia and Diabetic Renal Disease....Pages 307-320 Cation Transport, Hypertension and Diabetic Nephropathy....Pages 321-330 Microalbuminuria in Young Patients with Type 1 Diabetes....Pages 331-340 Early Renal Hyperfunction and Hypertrophy in IDDM Patients Including Comments on Early Intervention....Pages 341-350 The Concept of Incipient Diabetic Nephropathy and Effect of Early Antihypertensive Intervention....Pages 351-360 Comparative Study of the Effect of Ace Inhibitors and other Antihypertensive Agents on Proteinuria in Diabetic Patients....Pages 361-374 Clinical Trials in Overt Diabetic Nephropathy....Pages 375-383 Antihypertensive Treatment in NIDDM, with Special Reference to Abnormal Albuminuria....Pages 385-396 The Course of Incipient and Overt Diabetic Nephropathy: The Perspective of More Optimal Insulin Treatment....Pages 397-403 Non-Glycaemic Intervention in Diabetic Nephropathy: The Role of Dietary Protein Intake....Pages 405-414 Microalbuminuria and Diabetic Pregnancy....Pages 415-422 Diabetic Nephropathy and Pregnancy....Pages 423-432 Urinary Tract Infection and Diabetes: Diagnosis and Treatment....Pages 433-437 Acute Renal Failure in Diabetics....Pages 439-450 Contrast Media Induced Nephropathy in Diabetic Renal Disease....Pages 451-460 Renal Papillary Necrosis in Diabetic Patients....Pages 461-468 Preparations for Renal Replacement Therapy in Diabetic Patients....Pages 469-472 Evolution Worldwide of the Treatment of Patients with Advanced Diabetic Nephropathy by Renal Replacement Therapy....Pages 473-480 Haemodialysis in Type 1 and Type 2 Diabetic Patients with end Stage Renal Failure....Pages 481-488 Continuous Ambulatory Peritoneal Dialysis in Uremic Diabetics....Pages 489-511 Simultaneous Pancreas and Kidney Transplantation: Indication and Results....Pages 513-520 Renal Transplantation for Diabetic Nephropathy....Pages 521-537 Prevention of Diabetic Renal Disease with Special Reference to Microalbuminuria....Pages 539-549 A Comparison of Progression in Diabetic and Non-Diabetic Renal Disease: Similarity of Progression Promoters....Pages 551-559 Combination Therapy for Hypertension and Renal Disease in Diabetics as Compared to Non-Diabetics....Pages 561-568 Back Matter....Pages 569-578