The Kidney and Body Fluids in Health and Disease

This volume was designed as a text for medical students, house officers, and even clinicians. It deals with the most common problems in nephrology, providing new insight into how to improve clinical skills. A comprehensive overview of renal physiology and electrolyte disorders lays the groundwork for a clear presentation of the pathophysiological principles that underlie these disorders and a step-by-step presentation of the mechanisms behind the signs and symptoms of kidney failure. The origins of this book can be traced to the teaching of a Renal Pathophysiology course at the Washington University School of Medicine, beginning in the mid-1960s. When changes in the medical school curriculum took place in the early 1970s, an effort was made to synthesize the minimum core curriculum for sophomore medical students, and the distillation of "essential material" to be covered in the area of renal pathophysiology led to the development of the first edition of a renal syllabus. This syllabus has been used in our department since 1974, and, following some of the recommendations and critiques of students and faculty, it has been entirely reworked many times to improve its effectiveness and value. This book is a direct extension of that syllabus, integrated with contri­ butions from faculty members in our Renal Division, and expanded to include a section on therapy in most chapters. It is our hope that this format will serve the needs of not only sophomore and senior medical students, but also house officers, nephrology fellows, and clinicians. Front Matter....Pages i-xxi Front Matter....Pages 1-1 Introduction to the Physiology of Body Fluids....Pages 3-34 Homeostatic and Excretory Functions of the Kidney....Pages 35-63 Nonexcretory Functions of the Kidney....Pages 65-90 Front Matter....Pages 91-91 Pathophysiology of Volume Regulation and Sodium Metabolism....Pages 93-118 Edema and Edema-Forming States....Pages 119-147 The Pathophysiologic Bases for Alterations in Water Balance....Pages 149-198 Pathophysiology of Potassium Metabolism....Pages 199-221 Pathophysiology of Acid-Base Metabolism....Pages 223-267 Pathophysiology of Calcium, Magnesium, and Phosphorus Metabolism....Pages 269-330 Front Matter....Pages 331-331 Pathophysiology of Hypertension....Pages 333-366 Front Matter....Pages 367-367 Proteinuria and the Nephrotic Syndrome....Pages 369-398 Pathology and Pathophysiology of Proteinuric Glomerular Disease....Pages 399-438 Front Matter....Pages 441-441 Pathophysiology of Acute Renal Failure....Pages 443-461 Pathophysiology of Chronic Renal Failure....Pages 463-490 Pathophysiological Principles in the Treatment of Patients with Renal Failure....Pages 491-520 Front Matter....Pages 521-521 Pathophysiology of Nephrolithiasis....Pages 523-553 Front Matter....Pages 555-555 Renal Pharmacology....Pages 557-580 Back Matter....Pages 581-593