The isoquinoline alkaloids: chemistry and pharmacology (Organic chemistry; a series of monographs)

The Isoquinoline Alkaloids: Chemistry and Pharmacology presents an overview of the chemistry, biogenesis, spectroscopy, and pharmacology of the isoquinoline alkaloids. This book examines the significant and interesting aspects of alkaloids. Organized into 32 chapters, this book starts with a discussion of the biogenesis of the isoquinolines and the various pharmacological effects of simple tetrahydroisoquinolines that have stimulant and convulsive properties. This text then explores the infrared absorptions, with emphasis on wavelength and frequency. Other chapters include topics on synthesis, degradation, reactions, absolute configuration, as well as on ultraviolet and nuclear magnetic resonance spectroscopy. This book further explores the various methods available for the preparation of simple tetrahydroisoquinolines, including the Bischler–Napieralski, Pictet–Spengler, and phenolic cyclization, as well as the Friedel–Crafts acylation. The last chapter deals with ancistrocladine, which is the first isoquinoline alkaloid found to possess a methyl group. Biochemists and biophysicists will find this book useful. Content: Front Matter Page III Copyright page Page IV Dedication Page V Preface Pages XVII-XVIII MAURICE SHAMMA Chapter 1 - The Simple Tetrahydroisoquinolines Pages 1-43 Chapter 2 - The Benzylisoquinolines Pages 44-89 Chapter 3 - The Isoquinolones Pages 90-95 Chapter 4 - The Pavines and Isopavines 1 Pages 96-114 Chapter 5 - The Bisbenzylisoquinolines Pages 115-152 Chapter 6 - The Cularines Pages 153-164 Chapter 7 - The Cularine-Morphine Dimers Pages 165-168 Chapter 8 - The Dibenzopyrrocolines Pages 169-176 Chapter 9 - The Proaporphines Pages 177-193 Chapter 10 - The Aporphines Pages 194-228 Chapter 11 - Pakistanamine: A Proaporphine-Benzylisoquinoline Dimer Pages 229-231 Chapter 12 - The Aporphine-Benzylisoquinoline Dimers Pages 232-244 Chapter 13 - The Oxoaporphines Pages 245-258 Chapter 14 - The Phenanthrene Alkaloids Pages 259-264 Chapter 15 - Taspine Pages 265-267 Chapter 16 - The Protoberberines and Retroprotoberberines Pages 268-314 Chapter 17 - The Benzophenanthridines Pages 315-343 Chapter 18 - The Protopines Pages 344-358 Chapter 19 - The Phthalideisoquinolines Pages 359-379 Chapter 20 - The Spirobenzylisoquinolines Pages 380-398 Chapter 21 - The Rhoeadines and Papaverrubines Pages 399-417 Chapter 22 - Protostephanine Pages 418-425 Chapter 23 - Emetine and Related Alkaloids Pages 426-457 Chapter 24 - Autumnaline: A Phenethylisoquinoline Pages 458-464 Chapter 25 - Melanthioidine: A Bisphenethylisoquinoline Pages 465-468 Chapter 26 - The Homoaporphines and Homoproaporphines Pages 469-482 Chapter 27 - The Homoprotoberberines Pages 483-489 Chapter 28 - The Phenyltetrahydroisoquinolines Pages 490-494 Chapter 29 - The N -Benzyltetrahydroisoquinolines Pages 495-496 Chapter 30 - Cherylline Pages 497-500 Chapter 31 - The Naphthalenoisoquinolines Pages 501-504 Chapter 32 - Addenda Pages 505-520 Appendix - Occurrence of Isoquinoline Alkaloids by Plant Families Pages 521-522 Author Index Pages 523-544 Subject Index Pages 545-594 Organic Chemistry: A Series of Monographs Pages 595-596