The Importance of Laboratory Animal Genetics, Health, and the Environment in Biomedical Research

The Importance of laboratory animal genetics Health, and the Environment in Biomedical Research Abstract: The Importance of laboratory animal genetics Health, and the Environment in Biomedical Research Content: Academic Press Rapid Manuscript Reproduction , Page ii Front Matter , Page iii Copyright , Page iv Contributors , Pages ix-x Participants , Pages xi-xii Preface , Page xiii Introductory Remarks , Page xv , HENRY L. FOSTER OVERVIEW OF THE STATE OF THE ART IN HEALTH MONITORING , Pages 3-23 , Melvin W. Balk THE EFFECTS OF HEALTH AND HEALTH MONITORING ON TOXICOLOGY STUDIES , Pages 25-43 , Ralph Heywood, David P. Buist THE EFFECTS OF HEALTH AND HEALTH MONITORING ON ONCOLOGY STUDIES , Pages 45-60 , Thomas E. Hamm Jr. THE EFFECTS OF HEALTH AND HEALTH MONITORING ON PHARMACOLOGIC STUDIES , Pages 61-72 , Werner Wilk OVERVIEW OF THE STATE OF THE ART IN GENETIC MONITORING , Pages 75-100 , H.J. Hedrich MALFORMATIONS OF GENETIC ORIGIN IN TERATOLOGY STUDIES: CASES OF CLEFT PALATE IN RABBITS , Pages 101-114 , Remy J. Le Bail, Jerome J. Pasquet, Jean-Yves F. Detaille THE IMPACT OF GENETICS AND GENETIC MONITORING ON ONCOLOGICAL STUDIES: Some aspects of leukemogenesis in the AKR strain , Pages 115-123 , Eva Klein IMPACT OF GENETICS AND GENETIC MONITORING ON PHARMACOLOGY STUDIES , Pages 125-158 , Daniel W. Nebert OVERVIEW OF THE STATE OF THE ART IN ENVIRONMENTAL MONITORING , Pages 161-182 , Trevor McSheehy THE EFFECTS OF ENVIRONMENT AND ENVIRONMENTAL MONITORING ON TOXICOLOGY STUDIES , Pages 183-193 , Pierre Duprat, Richard Jensen, Roger Owen, Andras Fabry, Philippe Conquet THE EFFECTS OF ENVIRONMENT AND ENVIRONMENTAL MONITORING ON ONCOLOGY STUDIES , Pages 195-205 , Andre-Laurent Parodi THE EFFECTS OF ENVIRONMENT AND ENVIRONMENTAL MONITORING ON PHARMACOLOGY STUDIES , Pages 207-222 , H.-J. Hapke MONOCLONAL ANTIBODIES – IMPORTANCE OF THE LABORATORY ANIMAL , Pages 225-237 , Karen M. Miner, Regina R. Skelly, Edward C. Hayes, Maureen T. Gammon, Christine L. Manyak THE IMPORTANCE OF LABORATORY ANIMAL GENETICS, HEALTH, AND ENVIRONMENT – THE LABORATORY ANIMAL SPECIALIST'S VIEWPOINT , Pages 239-257 , C. Max Lang QUALITY ANIMALS FOR BIOMEDICAL RESEARCH: LESSONS FROM THE PAST, OPPORTUNITIES FOR THE FUTURE , Pages 259-270 , Joe R. Held MHC, MICE, MEN, AND BUSINESSMEN , Pages 271-280 , Jan Klein Index , Pages 281-284 The Importance of Laboratory Animal Genetics, Health, and the Environment in Biomedical Research documents the proceedings of the Fifth Charles River International Symposium on Laboratory Animals, in Heidelberg, Federal Republic of Germany, March 14-16, 1983. These papers examine how the health and genetic monitoring of laboratory animals, coupled with environmental influences, affect the investigations of oncologists, toxicologists, or pharmacologists. The book is organized into four parts. Part I focuses on the health monitoring of laboratory animals for biomedical research. It includes studies on the effects of health and health monitoring in toxicology studies, oncology studies, and pharmacologic studies. Part II deals with the genetic monitoring of laboratory animals. It examines the causes of genetic alternation in laboratory animals and ways to prevent them. Part III considers the environmental monitoring that is necessary for research on laboratory animals. Part IV on new research frontiers includes studies on the production of monoclonal antibodies for the experimental and therapeutic modulation of laboratory animals, and the quality control aspects of animal experimentation.