The impact of protein chemistry on the biomedical sciences : symposium in honor of Anfinsen's 65th birthday, papers

The Impact of Protein Chemistry on the Biomedical Sciences focuses on the structure, function, and synthesis of proteins. This book examines the various approaches on how amino acids are polymerized in vitro, which involves the physical, chemical, immunological, enzymologic, biosynthetic, and organic synthetic techniques. Comprised of five parts encompassing 27 chapters, this book starts with an overview of Christian B. Anfinsen's role in the development of protein chemistry and the training of scientists who have advanced their experiences in his laboratory to pioneer in the field of biological and medical sciences. This text then examines the synthesis of albumin molecule in the bloodstream as it carries cystine, hematin, bilirubin, fatty acids, and aromatic compounds. Other chapters discuss the kinetic experiments of hydrogen exchange in aqueous solution between peptide molecules and solvent water. This text also introduces the reader to the lipoprotein–atherosclerosis connection by studying the metabolism of plasma lipoproteins. This book is a valuable source of information for biologists, chemical biologists, scientists, and students. Content: Inside Front Cover , Page ii Front Matter , Page iii Copyright , Page iv Contributors and Participants , Pages xiii-xv Preface , Pages xvii-xx , Alan N. Schechter, Ann Dean, Robert F. Goldberger Introduction: The Anfinsen Series , Pages xxi-xxix , DONALD S. FREDRICKSON Christian Anfinsen and the National Institutes of Health , Pages xxxi-xxxii , J. EDWARD RALL CHAPTER 1 - Historical Perspective of Biomedical Research , Pages 3-6 , A. BAIRD HASTINGS CHAPTER 2 - Basic Research as an Investment in the Nation's Future , Pages 7-19 , GILBERT S. OMENN CHAPTER 3 - From Polypeptide Chemistry to Muscle Contraction , Pages 23-37 , WILLIAM F. HARRINGTON CHAPTER 4 - Serum Albumin: Adventures of a Circulating Protein , Pages 39-55 , THEODORE PETERS JR. CHAPTER 5 - What Does Hydrogen Exchange Tell Us about Proteins? , Pages 57-65 , AASE HVIDT CHAPTER 6 - The Mechanism of Protein Folding , Pages 67-81 , HIROSHI TANIUCHI CHAPTER 7 - Chemical Syntheses and Biological Activities of Cyclic Peptides , Pages 83-89 , NOBUO IZUMIYA CHAPTER 8 - Affinity Labeling: From Nuclease to Cells , Pages 91-105 , MEIR WILCHEK CHAPTER 9 - Structural Bases of Biological Function: From Nucleases to Neurophysins , Pages 107-120 , IRWIN M. CHAIKEN CHAPTER 10 - Staphylococcal Nuclease, a Calcium-Binding Protein: Path to the Vitamin K-Dependent Blood Coagulation Proteins , Pages 121-133 , BRUCE FURIE CHAPTER 11 - Molecular Evolution, Antibody Formation, and Embryogenesis , Pages 137-157 , WILLIAM J. DREYER CHAPTER 12 - The Combining Site of Antibodies: From the Protein to the Gene , Pages 159-176 , DAVID GIVOL CHAPTER 13 - Protein Conformation and Biological Function: From Ribonuclease to Antigens and Antibodies , Pages 177-186 , MICHAEL SELA CHAPTER 14 - Antigenic Determinants of Proteins and Synthetic Vaccines , Pages 187-198 , RUTH ARNON CHAPTER 15 - Staphylococcal Nuclease as a Model Antigen , Pages 199-212 , DAVID H. SACHS CHAPTER 16 - Autoimmunity to Acetylcholine Receptor and Its Significance for Myasthenia Gravis , Pages 213-225 , SARA FUCHS CHAPTER 17 - The Antibody Combining Site: A Basis for a New Pharmacology , Pages 227-245 , EDGAR HABER CHAPTER 18 - Lipoproteins and Atherosclerosis: A Problem in Cell Biology , Pages 249-270 , DANIEL STEINBERG CHAPTER 19 - Protein Chemistry and the Cardiologist , Pages 271-278 , ARNOLD M. KATZ CHAPTER 20 - Regulation of Cyclic Nucleotide Metabolism: From Proteins to Cyclic Nucleotides and Back , Pages 279-290 , MARTHA VAUGHAN CHAPTER 21 - Activation of Adenylate Cyclase in the Adrenal Cortex , Pages 291-303 , DAVID A. ONTJES CHAPTER 22 - Studies of Human Chorionic Gonadotropin: Implications for Fertility Research , Pages 305-317 , ROBERT E. CANFIELD CHAPTER 23 - Excursions of a Protein Vagabond: From Nuclease to Affinity Chromatography to Hormone Receptors and Membranes , Pages 319-327 , PEDRO CUATRECASAS CHAPTER 24 - Early Embryonic Development: Normal and Abnormal , Pages 331-348 , CHARLES J. EPSTEIN CHAPTER 25 - Molecular Regulation in Muscle Development , Pages 349-362 , HENRY F. EPSTEIN CHAPTER 26 - Interferon: Past, Present, and Future , Pages 363-373 , KATHRYN C. ZOON CHAPTER 27 - Parathyroid Hormone: Chemistry, Biosynthesis, and Mode of Action , Pages 375-394 , JOHN T. POTTS JR. Bibliography , Pages 395-405 Index , Pages 407-415