The Immunoglobulin Receptors And Their Physiological And Pathological Roles In Immunity (immunology And Medicine)

Antibodies are crucial to the fine specificity of the immune system. An effective functioning of these molecules requires interaction with immune cells. Receptors for antibodies, Fc receptors, provide this critical link between the humoral and cellular branches of the immune system. This book presents a comprehensive overview of the different Fc receptors currently recognized. The first part of the book contains state-of-the-art overviews on the biological role of FcR. The latest information on FcR heterogeneity, FcR physiology, FcR-ligand recognition, their crucial coordinating role in immunity, interactions with other immunoreceptors, and the role of FcR in immunoglobulin transport and catabolism are discussed. The clinical importance of FcR is developed in the second part of the book. The well-recognized roles of FcR in allergy, inflammation, infectious diseases, autoimmune disorders, and immunotherapeutic importance are reviewed. The information in this book is easily accessible and should be helpful for researchers and clinical specialists as a convenient overview of the field, as well as a comprehensive introduction for students starting in this area of research. Front Matter....Pages i-xv Introduction to the field....Pages 1-7 Front Matter....Pages 9-9 Molecular basis for the interaction of Fc receptors with immunoglobulins....Pages 11-35 Fc receptor genetics and the manipulation of genes in the study of FcR biology....Pages 37-48 Commentary....Pages 49-50 The polymeric immunoglobulin receptor....Pages 51-62 Multiple roles of FcRn....Pages 63-71 Commentary The polymeric immunoglobulin receptor and the Brambell receptor: non-haematopoietic FcRs, with much to compare....Pages 73-82 Signals initiated by the high affinity FcR for IgE....Pages 83-93 Phagocyte Fc receptors for IgG....Pages 95-107 Human IgA Fc receptors (FcαR)....Pages 109-117 Platelet Fc receptors for IgG and IgE....Pages 119-134 Polymorphisms of FcγRIIIa on NK cells and macrophages....Pages 135-140 Cooperation between IgG Fc receptors and complement receptors in host defence....Pages 141-149 Commentary....Pages 151-154 FcγR and IgG-mediated negative regulation of immune responses....Pages 155-167 FcγR on T cells....Pages 169-183 Role of IgG and IgE FcR in antigen presentation....Pages 185-194 Structure and function of CD23....Pages 195-206 Commentary on FcR regulation of development and function of the immune system....Pages 207-211 Front Matter....Pages 213-213 The role and use of recombinant receptors in the investigation and control of antibody-induced inflammation....Pages 215-231 Front Matter....Pages 213-213 FcR and autoimmunity....Pages 233-248 Heparin-induced thrombocytopenia as a model for FcγRII-mediated disease....Pages 249-266 Fcγ receptor polymorphisms: clinical aspects....Pages 267-278 Soluble FcγR, a biological perspective....Pages 279-290 FcγR-directed immunotherapies....Pages 291-305 The rewards of conversion to ‘FcRism’....Pages 307-309 Fc receptors: historical perspectives and a look to the future....Pages 311-313 Back Matter....Pages 315-323