The immune system; genes, receptors and signals; proceedings of a conference held at Squaw Valley, California, 1974

The Immune System: Genes Receptors, Signals provides information pertinent to the complexity of immune mechanisms. This book describes the immune response genes and products, which point to another multigene system controlling immune responsiveness. Organized into 37 chapters, this book begins with an overview of the details of antibody structure that continue to be of importance to an understanding of the regulation of the immune reactions. This text then examines the evidence that individual antibody species are capable of binding many structurally dissimilar haptens. Other chapters consider the conceptual framework generally accepted by immunologists, which states that antibodies are specific for the antigen used to elicit the immune response. This book discusses as well the mechanism underlying the biosynthesis of antibody binding sites, which is unprecedented in its adaptability. The final chapter deals with the genetic controls of specific immune responses. This book is a valuable resource for immunologists and research workers. Content: Inside Front Cover , Page ii Front Matter , Page iii Copyright , Page iv LIST OF CONTRIBUTORS , Pages ix-xv PREFACE , Pages xvii-xxi THE CONDUCTOR OF THE IMMUNOLOGICAL ORCHESTRA , Pages xxii-xxiii ACKNOWLEDGMENTS , Page xxiv ANTIBODY STRUCTURE AND THE IMMUNE RESPONSE , Pages 1-6 , Henry Metzger THE THREE-DIMENSIONAL STRUCTURE OF THE ANTIGEN BINDING SITE OF McPC 603 PROTEIN , Pages 7-14 , E.A. Padlan, D.M. Segal, G.H. Cohen, D.R. Davies, S. Rudikoff, M. Potter KINETIC MAPPING OF ANTIBODY BINDING SITES , Pages 15-35 , Israel Pecht MULTISPECIFICITY OF THE ANTIBODY COMBINING REGION AND ANTIBODY DIVERSITY , Pages 37-52 , John K. Inman POLYFUNCTIONAL ANTIBODY COMBINING REGIONS , Pages 53-67 , Frank F. Richards, W.H. Konigsberg, B.N. Manjula, R.W. Rosenstein, Janos M. Varga, L.M. Amzel, R.J. Poljak, F. Saul A STUDY OF V REGION GENES USING ALLOTYPIC AND IDIOTYPIC MARKERS , Pages 69-88 , T.J. Kindt, A.L. Thunberg, M. Mudgett, D.G. Klapper FIRST ORDER CONSIDERATIONS IN ANALYZING THE GENERATOR OF DIVERSITY , Pages 89-117 , Melvin Cohn, Bonnie Blomberg, William Geckeler, William Raschke, Roy Riblet, Martin Weigert ANTIBODY DIVERSITY: AN ASSESSMENT , Pages 119-139 , L. Hood, P. Barstad, E. Loh, C. Nottenburg MOLECULAR AND FUNCTIONAL PROPERTIES OF LYMPHOCYTE SURFACE IMMUNOGLOBULIN , Pages 141-173 , John J. Marchalonis ALLOANTISERUM INDUCED BLOCKADE OF IR GENE PRODUCT FUNCTION , Pages 175-190 , W.E. Paul, E.M. Shevach, S.Z. Ben-Sasson, F. Finkelman, I. Green FURTHER CHARACTERIZATION OF Ia (IMMUNE RESPONSE REGION ASSOCIATED) ANTIGEN MOLECULES , Pages 191-200 , Susan E. Cullen, Stanley G. Nathenson RECEPTORS FOR ANTIGEN ON “B, T, B-T AND NUL” LYMPHOCYTES IN NORMAL AND “NUDE” MICE , Pages 201-215 , Francis Loor, Georges E. Roelants CYTOPHILIC PROPERTIES OF T LYMPHOCYTE MEMBRANE ASSOCIATED IMMUNOGLOBULINS , Pages 217-232 , Robert E. Cone IN-VITRO BIOSYNTHESIS AND MOLECULAR ARRANGEMENT OF SURFACE IMMUNOGLOBULIN OF MOUSE THYMUS CELLS , Pages 233-246 , Chaya Moroz, Nitza Lahat THE LYMPHOCYTE PLASMA MEMBRANE , Pages 247-257 , Maxtin C. Raff, Stefanello de Petris PROBING LYMPHOCYTE MEMBRANE ORGANIZATION , Pages 259-269 , Leon Wofsy POLYCLONAL MITOGENS AND THE NATURE OF B LYMPHOCYTE ACTIVATION MECHANISMS , Pages 271-297 , Melvyn Greaves, George Janossy, Marc Feldmann, Michael Doenhoff THE ORGANIZATION OF IMMUNOGLOBULIN GENES , Pages 299-317 , P. Leder, T. Honjo, S. Packman, D. Swan, M. Nau, B. Norman QUANTITATIVE ESTIMATION OF THE mRNA FOR H-CHAIN IMMUNOGLOBULIN , Pages 319-338 , Ronald H. Stevens MUTATIONS IN MOUSE MYELOMA CELLS , Pages 339-351 , Barbara K. Birshtein, Jean-Louis Preud'homme, Matthew D. Scharff SPONTANEOUS MUTATION IN IMMUNOGLOBULIN GENES , Pages 353-355 , David S. Secher, Richard G.H. Cotton, Nicholas J. Cowan, Cesar Milstein BIOGRAPHY OF THE B CELL , Pages 357-365 , Norman R. Klinman, Joan L. Press, Allan R. Pickard, Robert T. Woodland, A. Faye Dewey THE GENERATION OF DIVERSITY WITHIN SINGLE CLONES OF ANTIBODY-FORMING CELLS , Pages 367-386 , A.J. Cunningham, Linda M. Pilarski B MEMORY CELLS IN THE PROPOGATION OF STABLE CLONES OF ANTIBODY FORMING CELLS , Pages 387-406 , A.R. Williamson, A.J. McMichael, I.M. Zitron ANTIGEN DEPENDANCE OF CLONAL MEMORY , Pages 407-413 , A.J. McMichael REGULATION OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE BY THYMIC-DERIVED CELLS , Pages 415-429 , Phillip J. Baker, Benjamin Prescott, Philip W. Stashak, Diana F. Amsbaugh THYMOCYTE SUBPOPULATION WITH SUPPRESSIVE ACTIVITY , Pages 431-445 , Wulf Droege SUPPRESSOR T CELLS IN LOW ZONE TOLERANCE , Pages 447-453 , E. Kölsch, R. Mengersen, G. Weber ANTIBODY INDUCED SUPPRESSOR T-CELLS , Pages 455-469 , Leonore A. Herzenberg, Charles M. Metzler T CELL REGULATION: THE “SECOND LAW OF THYMODYNAMICS” , Pages 471-484 , Richard K. Gershon T CELL FACTORS IN THE REGULATION OF THE B CELL RESPONSE , Pages 485-496 , Richard W. Dutton ANTIGEN SPECIFIC T CELL FACTORS AND THEIR ROLE IN THE REGULATION OF T-B INTERACTION , Pages 497-510 , Marc Feldmann THE NATURE OF THE SIGNALS REQUIRED FOR THE INDUCTION OF ANTIBODY SYNTHESIS , Pages 511-532 , James Watson IDIOTYPIC RECEPTORS FOR ALLOANTIGEN ON T CELLS? , Pages 533-551 , Hans Binz, Jean Lindenmann, Hans Wigzell MANIPULATION OF A TOLERANT STATE: CELLS AND SIGNALS , Pages 553-567 , Jacques M. Chiller, Jacques A. Louis, Barry J. Skidmore, William O. Weigle THE ROLE OF HISTOCOMPATIBILITY GENE PRODUCTS IN COOPERATIVE CELL INTERACTIONS BETWEEN T AND B LYMPHOCYTES , Pages 569-596 , David H. Katz, Baruj Benacerraf Ir GENES AND ANTIGEN RECOGNITION , Pages 597-632 , Hugh O. McDevitt, Kathleen B. Bechtol, Günter J. Hämmerling, Peter Lonai, Terry L. Delovitch