The hepatobiliary system : fundamental and pathological mechanisms : [proceedings of the second NATO Advanced Study Institute on the Biliary System, Aalborg, Denmark, August 24-30, 1975

A volume on the biliary system appeared in 1965, based on a symposium of the NATO Advanced Institute held in September, 1963, in Newcastle upon Tyne in England. It soon became an authorita­ tive text on the problems of the biliary tract and, for instance, the discussion on the biliary secretion of organic anions, organic cations and inorganic ions were classic references. The worn pages of the volume in many libraries, including my own, bespeak its usefulness over ten long years. The initiative and energy of the Director of the first Institute have to be admired, even more so since he was able to assemble a Second Institute in Aalborg, Denmark, in 1975. His wisdom is reflected in the selection of the subjects discussed. The comparison between the two volumes tells something about the advancement in the time interval in knowledge about liver and biliary tract diseases, about the turnover of researchers interested in the liver and its diseases, and also about the present philosophy in biologic science. For this com­ parison, this volume is particularly suited because, in contrast to many other recent conferences, the more leisurely pace of the NATO Institutes permits more comprehensive but still scholarly reviews of the problems. The foreword of the first volume, written by my colleague, the late Harry Sobotka, expresses his, now dated, astonishment about the progress of knowledge of biology of the bile, so much less accessible to study than urine. Front Matter....Pages i-xvii The Hepatobiliary System: Retrospect and Prospect. A Personal View....Pages 1-8 Front Matter....Pages 9-9 Membrane Structure....Pages 11-31 Transport through Biological Membranes....Pages 33-41 Mechanism of Transport of Inorganic Ions into Bile....Pages 43-60 Biochemical Studies on Bile Secretion....Pages 61-80 On the Structure and Function of Ligandin and Z Protein....Pages 81-107 Excretion of Xenobiotic Compounds in Bile....Pages 109-134 Front Matter....Pages 143-143 The Fine Structure of Liver Cells....Pages 145-177 Ultrastructural Changes Induced by Drugs in the Liver....Pages 179-203 Liver Damage and Regeneration after Poisoning....Pages 205-225 Toxic Effects of Lithocholate on the Liver and Biliary Tree....Pages 227-243 Fine Structure of the Biliary Tree....Pages 245-265 Bile Duct Function in Biliary Secretion....Pages 267-285 Kinetics of Hepatic Uptake and Excretion of Organic Anions....Pages 287-298 Front Matter....Pages 307-307 Bilirubin Conjugates in Bile....Pages 309-337 Comparative Studies on the Structures of Conjugated Bilirubin-IXα and Changes in Cholestasis....Pages 339-356 Front Matter....Pages 359-359 Some New Aspects of the Regulation of Cholesterol Biosynthesis and Metabolism of Mevalonate....Pages 361-387 Bile Acid Metabolism and its Control....Pages 389-407 Diurnal Variation in Bile Acid Biosynthesis....Pages 409-432 Hepatic Transport of Bile Acids....Pages 433-452 Front Matter....Pages 359-359 Formation, Metabolism, and Excretion of Bile Salt Sulfates in Man....Pages 453-468 The Allo Bile Acids....Pages 469-483 Dissolution of Gallstones by Chenodeoxycholic Acid....Pages 485-507 Front Matter....Pages 515-515 The Enterohepatic Circulation of Bile Acids in Man....Pages 517-527 Bile Phospholipids : Origin and Function....Pages 529-553 Biliary Lipids in Pregnancy....Pages 555-575 Front Matter....Pages 589-589 Intrahepatic Cholestasis....Pages 591-603 Molecular Pathology of Cholestasis....Pages 605-629 Back Matter....Pages 631-654