قلب در بیماری‌های روماتیسمی، خودایمنی و التهابی: پاتوفیزیولوژی، جنبه‌های بالینی و رویکردهای درمانی

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. __The Heart in Rheumatic, Autoimmune and Inflammatory Diseases__ examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. Content: Dedication,Front Matter,Copyright,List of Contributors,About the Editor,Preface,AcknowledgmentsEntitled to full textPart I: Immune Medicated Cardiac Injury, Accelerated Atherosclerosis and the Study of Cardiac Involvements in Systemic DiseasesChapter 1 - Pathophysiology of Autoimmunity and Immune-Mediated Mechanisms in Cardiovascular Diseases, Pages 3-23, O. Shamriz, U. Nussinovitch, N.R. Rose Chapter 2 - Organ-Specific Autoimmune Myocardial Diseases: From Pathogenesis to Diagnosis and Management, Pages 25-48, A.L.P. Caforio, R. Marcolongo, G. Malipiero, C. Agostini, M. Seguso, N. Gallo, M. Plebani, S. Iliceto Chapter 3 - Autoantibodies Directed Against G-Protein-Coupled Receptors in Cardiovascular Diseases: Basics and Diagnostics, Pages 49-63, B. Bornholz, G. Wallukat, D. Roggenbuck, I. Schimke Chapter 4 - Immune-Mediated Accelerated Atherosclerosis, Pages 65-89, S. Gruber, D. Tsiantoulas, C.J. Binder Chapter 5 - A Study of Cardiac Function, Atherosclerosis, and Arrhythmogenicity, Pages 91-125, U. Nussinovitch, A. Sandoo, M. Malik Chapter 6 - Rheumatoid Arthritis, Pages 129-165, T. Dimitroulas, A. Sandoo, S. Skeoch, M. O’Sullivan, M. Yessirkepov, L. Ayvazyan, A.Y. Gasparyan, G. Metsios, G.D. Kitas Chapter 7 - Juvenile Idiopathic Arthritis, Pages 167-187, A. Ravelli, B. Schiappapietra, S. Verazza, A. Martini Chapter 8 - Spondyloarthritides: Ankylosing Spondylitis, Psoriatic Arthritis, and Reactive Arthritis, Pages 189-211, J. Braun, S.C. Heslinga, H.J. Trappe, M.T. Nurmohamed Chapter 9 - Polymyalgia Rheumatica, Pages 213-231, E. Bartoloni, G. Pucci, A. Alunno, R. Gerli, G. Schillaci Chapter 10 - Systemic Lupus Erythematosus, Pages 235-267, K. Tselios, M.B. Urowitz Chapter 11 - Neonatal Lupus, Pages 269-280, C. Miliaresis, C. Phoon, J. Buyon, D. Friedman Chapter 12 - Sjögren’s Syndrome, Pages 281-300, S. Fragkioudaki, H.M. Moutsopoulos, C.P. Mavragani Chapter 13 - Systemic Sclerosis, Pages 301-326, A. Vacca Chapter 14 - Dermatomyositis and Polymyositis, Pages 327-346, L.P. Diederichsen, H. Sanner, I. Sjaastad, I.E. Lundberg Chapter 15 - Gout, Pages 349-364, C. van Durme, R. Landewé Chapter 16 - Giant Cell Arteritis, Pages 367-387, M.J. Koster, E.L. Matteson, K.J. Warrington Chapter 17 - Takayasu’s Arteritis, Pages 389-415, H. Zhang, L. Yang, X. Jiang Chapter 18 - Polyarteritis Nodosa, Pages 419-427, L. Guillevin Chapter 19 - Kawasaki Disease, Pages 429-455, C. Reuter, L. Mithal, S. Shulman Chapter 20 - ANCA-Associated Vasculitis: Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss Syndrome) and Granulomatosis With Polyangiitis (Wegener’s Granulomatosis), Pages 459-502, M.R. Hazebroek, P. van Paassen, R. Dennert, S. Heymans Chapter 21 - Behçet’s Disease, Pages 505-526, A. Soriano, N. Pipitone, C. Salvarani Chapter 22 - Rheumatic Fever and Rheumatic Heart Disease, Pages 529-551, L. Guilherme, R.O. Sampaio, S. Freschi de Barros, K.F. Köhler, G.S. Spina, F. Tarasoutchi, J. Kalil Chapter 23 - Chagas Cardiomyopathy, Pages 553-574, F. Fernandes, C.H. Valente Moreira, J.M. Barbosa-Ferreira, E.C. Sabino Chapter 24 - Familial Mediterranean Fever, Pages 577-614, U. Nussinovitch, A. Livneh Chapter 25 - Desirable and Adverse Effects of Antiinflammatory Agents on the Heart, Pages 617-643, M. Imazio, S. Maestroni, A. Valenti, V. Ramoni, A. Brucato Chapter 26 - The Effects of Immunosuppressive and Cytotoxic Drugs on the Heart, Pages 645-657, S.D. Russell Chapter 27 - Autoantibody-Directed Therapy in Cardiovascular Diseases, Pages 659-679, J. Müller, G. Wallukat, I. Schimke Chapter 28 - Cardiac Immunomodulation, Pages 681-714, S. Könemann, M. Dörr, S.B. Felix Index, Pages 715-739 Part I: Immune Medicated Cardiac Injury, Accelerated Atherosclerosis And The Study Of Cardiac Involvements In Systemic Diseases: Chapter 1 - Pathophysiology Of Autoimmunity And Immune-mediated Mechanisms In Cardiovascular Diseases. Chapter 2 - Organ-specific Autoimmune Myocardial Diseases: From Pathogenesis To Diagnosis And Management. Chapter 3 - Autoantibodies Directed Against G-protein-coupled Receptors In Cardiovascular Diseases: Basics And Diagnostics. Chapter 4 - Immune-mediated Accelerated Atherosclerosis. Chapter 5 - A Study Of Cardiac Function, Atherosclerosis, And Arrhythmogenicity -- Part Ii: Cardiac Manifestations Of Inflammatory Arthritis: Chapter 6 - Rheumatoid Arthritis. Chapter 7 - Juvenile Idiopathic Arthritis. Chapter 8 - Spondyloarthritides: Ankylosing Spondylitis, Psoriatic Arthritis, And Reactive Arthritis. Chapter 9 - Polymyalgia Rheumatica Part Iii: Cardiac Involvement In Autoimmune And Connective Tissue Diseases: Chapter 10 - Systemic Lupus Erythematosus. Chapter 11 - Neonatal Lupus. Chapter 12 - Sjögren’s Syndrome. Chapter 13 - Systemic Sclerosis. Chapter 14 - Dermatomyositis And Polymyositis -- Part Iv: Cardiac Manifestations Crystal-induced Arthritis: Chapter 15 - Gout -- Part V: Cardiac Manifestations Of Large Vessel Vasculitides: Chapter 16 - Giant Cell Arteritis. Chapter 17 - Takayasu’s Arteritis -- Part Vi: Cardiac Manifestations Of Medium Vessel Vasculitides: Chapter 18 - Polyarteritis Nodosa. Chapter 19 - Kawasaki Disease -- Part Vii: Cardiac Manifestations Of Small Vessel Vasculitides: Chapter 20 - Anca-associated Vasculitis: Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis (churg–strauss Syndrome) And Granulomatosis With Polyangiitis (wegener’s Granulomatosis) Part Viii: Cardiac Manifestations Of Variable Vessel Vasculitides: Chapter 21 - Behçet’s Disease -- Part Ix: Post-infectious Autoimmune Cardiac Diseases: Chapter 22 - Rheumatic Fever And Rheumatic Heart Disease. Chapter 23 - Chagas Cardiomyopathy -- Part X: Autoinflammation: Chapter 24 - Familial Mediterranean Fever -- Part Xi: Therapeutic Approaches: Mechanisms Of Action And Cardiac Effects: Chapter 25 - Desirable And Adverse Effects Of Antiinflammatory Agents On The Heart. Chapter 26 - The Effects Of Immunosuppressive And Cytotoxic Drugs On The Heart. Chapter 27 - Autoantibody-directed Therapy In Cardiovascular Diseases. Chapter 28 - Cardiac Immunomodulation. Edited By Udi Nussinovitch. Includes Index. Mode Of Access: World Wide Web.

The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives.

This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe.

• A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases.
• Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches.
• Presents an up-to-date “level of evidence” and “strengths of recommendations” for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.

"This book examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist." -- Publisher This book examines the complex mechanisms of autoimmune rheumatic conditions relating to cardiac diseases from a pathophysiological and clinical point of view. It addresses the increased risk that advanced atherosclerosis plays and its pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses