The Hair Fibre: Proteins, Structure and Development (Advances in Experimental Medicine and Biology Book 1054)

Hair is a sophisticated bio-based material, whether it is on a human head or part of a mammalian coat. In particular, the role of the proteins in the follicle, integral to hair development, are not well understood. This new book seeks to integrate the latest research in proteomic and morphological studies into a coherent description of fibre development from the follicle to its final mature, keratinized form. To achieve this the book has been divided into three sections. The first describes the keratins, their associated proteins and how they assemble into intermediate filaments in the fibre. The second covers the latest information on the morphological changes that occur from the base of the follicle, through the keratinization process to the mature fibre and the role that proteins play in this. The final section delves into fundamental fibre properties such as crosslinking, thermal and oxidative modifications and how these affect the mature fibre. The editors of this book are internationally recognised for their work in the area of mammalian hair, Jeffrey Plowman for his knowledge of the proteomics of the fibre, Santanu Deb-Choudhury for his work in the area of crosslinking in the fibre and Duane Harland for his understanding of the morphological development of the fibre. Together they have collected material from other international experts: Leopold Eckhart and Florian Ehrlich for their knowledge of the evolution of keratins; Dong Dong Wu and David Irwin for their studies on keratin associated protein evolution; David Parry and Bruce Fraser for their work on keratin and keratin associated protein structure and assembly; John McKinnon for his studies on macrofibril formation; Crisan Popescu for the thermodynamics of keratins; and Jolon Dyer for his oxidative modification studies of keratins. This book provides a comprehensive introduction, and useful reference guide to hair biology and will be of interest to both scientists and technologists. Front Matter ....Pages i-viii Front Matter ....Pages 1-1 Fibre Ultrastructure (Jeffrey E. Plowman, Duane P. Harland)....Pages 3-13 The Follicle Cycle in Brief (Jeffrey E. Plowman, Duane P. Harland)....Pages 15-17 Front Matter ....Pages 19-19 Diversity of Trichocyte Keratins and Keratin Associated Proteins (Jeffrey E. Plowman)....Pages 21-32 Evolution of Trichocyte Keratins (Leopold Eckhart, Florian Ehrlich)....Pages 33-45 Evolution of Trichocyte Keratin Associated Proteins (Dong-Dong Wu, David M. Irwin)....Pages 47-56 Structural Hierarchy of Trichocyte Keratin Intermediate Filaments (R. D. Bruce Fraser, David A. D. Parry)....Pages 57-70 Trichocyte Keratin-Associated Proteins (KAPs) (R. D. Bruce Fraser, David A. D. Parry)....Pages 71-86 Front Matter ....Pages 87-87 Introduction to Hair Development (Duane P. Harland)....Pages 89-96 Environment of the Anagen Follicle (Duane P. Harland)....Pages 97-108 Development of Hair Fibres (Duane P. Harland, Jeffrey E. Plowman)....Pages 109-154 Macrofibril Formation (Duane P. Harland, A. John McKinnon)....Pages 155-169 Front Matter ....Pages 171-171 Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins (Santanu Deb-Choudhury)....Pages 173-183 The Thermodynamics of Trichocyte Keratins (Crisan Popescu)....Pages 185-203 Oxidative Modification of Trichocyte Keratins (Jolon M. Dyer)....Pages 205-218 Back Matter ....Pages 219-225