The Growth Hormone/Insulin-Like Growth Factor Axis during Development (Advances in Experimental Medicine and Biology (567))

Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology. Basic Physiology Of The Growth Hormone/insulin-like Growth Factor (igf)-axis / Laura M. Frago And Julie A. Chowen -- Experimental Models For Understanding The Role Of Insulin-like Growth Factor-i And Its Receptor During Development / Jose Luis Trejo, Eva Carro And Deborah J. Burke -- Insulin-like Growth Factor Binding Proteins In Development / Josef V. Silha And Liam J. Murphy -- Growth Hormone, Insulin-like Growth Factors And The Female Reproductive System / Carolyn A. Bondy And Jian Zhou -- Skeletal Muscle / Ana M. Fernandez And Derek Leroith -- Cardiovascular And Respiratory Systems / Åsa Tivesten And Jörgen Isgaard. Hematopoiesis / Wilson Savino, Salete Smaniotto And Mireille Dardenne -- Brain Development / Gregory J. Popken ... [et Al.] -- Regulation Of Vertebrate Sensory Organ Development: A Scenario For Growth Hormone And Insulin-like Growth Factors Action / Amelia Diaz-casares ... [et Al.] -- Role Of Insulin-like Growth Factors In Neuronal Plasticity And Neuroprotection / Ignacio Torres Alemán -- Aging And Life Span / Holly M. Brown-borg -- Interactions Of Insulin-like Growth Factor-i And Estrogen In The Brain / Pablo Mendez, Gloria Patricia Cardona-gomez And Luis Miguel García-segura -- Cancer / Adda Grimberg. Genetic Basis Of Proportional Short Stature / Ángel Campos-barros, Karen E. Heath, Jesús Argente -- Future Perspectives: From Stem Cells And Igf Biology To The Clinic / Yvan Arsenijevic. Edited By Isabel Varela-nieto, Julie A. Chowen. Includes Bibliographical References And Index. Basic physiology of the growth hormone/insulin-like growth factor (IGF)-axis / Laura M. Frago and Julie A. Chowen -- Experimental models for understanding the role of insulin-like growth factor-I and its receptor during development / Jose Luis Trejo, Eva Carro and Deborah J. Burke -- Insulin-like growth factor binding proteins in development / Josef V. Silha and Liam J. Murphy -- Growth hormone, insulin-like growth factors and the female reproductive system / Carolyn A. Bondy and Jian Zhou -- Skeletal muscle / Ana M. Fernandez and Derek LeRoith -- Cardiovascular and respiratory systems / Åsa Tivesten and Jörgen Isgaard -- Hematopoiesis / Wilson Savino, Salete Smaniotto and Mireille Dardenne -- Brain development / Gregory J. Popken [and others] -- Regulation of vertebrate sensory organ development: a scenario for growth hormone and insulin-like growth factors action / Amelia Diaz-Casares [and others] -- Role of insulin-like growth factors in neuronal plasticity and neuroprotection / Ignacio Torres Alemán -- Aging and life span / Holly M. Brown-Borg -- Interactions of insulin-like growth factor-I and estrogen in the brain / Pablo Mendez, Gloria Patricia Cardona-Gomez and Luis Miguel García-Segura -- Cancer / Adda Grimberg -- Genetic basis of proportional short stature / Ángel Campos-Barros, Karen E. Heath, Jesús Argente -- Future perspectives: from stem cells and IGF biology to the clinic / Yvan Arsenijevic Basic Physiology of the Growth Hormone/Insulin-Like Growth Factor Axis....Pages 1-25 Experimental Models for Understanding the Role of Insulin-like Growth Factor-I and Its Receptor During Development....Pages 27-53 Insulin-like Growth Factor Binding Proteins in Development....Pages 55-89 Growth Hormone, Insulin-like Growth Factors and the Female Reproductive System....Pages 91-115 Skeletal Muscle....Pages 117-147 Cardiovascular and Respiratory Systems....Pages 149-166 Hematopoiesis....Pages 167-185 Brain Development....Pages 187-220 Regulation of Vertebrate Sensory Organ Development: A Scenario for Growth Hormone and Insulin-Like Growth Factors Action....Pages 221-242 Role of Insulin-Like Growth Factors in Neuronal Plasticity and Neuroprotection....Pages 243-258 Aging and Life Span....Pages 259-283 Interactions of Insulin-Like Growth Factor-I and Estrogen in the Brain....Pages 285-303 Cancer....Pages 305-339 Genetic Basis of Proportional Short Stature....Pages 341-383 Future Perspectives....Pages 385-412