The Functional Nucleus

"This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice. ". Font no determinada Front Matter....Pages i-vi Front Matter....Pages 1-1 Human Diseases Related to Nuclear Envelope Proteins....Pages 3-25 Front Matter....Pages 27-27 The Nucleolus: Structure and Function....Pages 29-49 Pre-mRNA Splicing and Disease....Pages 51-69 Acute Promyelocytic Leukaemia: Epigenetic Function of the PML-RARα Oncogene....Pages 71-98 Front Matter....Pages 99-99 Spatial Genome Organization and Disease....Pages 101-125 Telomeres and Chromosome Stability....Pages 127-154 Front Matter....Pages 155-155 Polycomb Bodies....Pages 157-173 The Continuing Flight of Ikaros....Pages 175-202 Front Matter....Pages 203-203 Senescence Associated Heterochromatic Foci: SAHF....Pages 205-218 DNA Repair Foci Formation and Function at DNA Double-Strand Breaks....Pages 219-237 Nuclear Domains and DNA Repair....Pages 239-257 The Interplay Between Inflammatory Signaling and Nuclear Structure and Function....Pages 259-282 Manipulation of PML Nuclear Bodies and DNA Damage Responses by DNA Viruses....Pages 283-312 Front Matter....Pages 313-313 Energy-Dependent Intranuclear Movements: Role of Nuclear Actin and Myosins....Pages 315-328 Nucleosome Dynamics Studied by Förster Resonance Energy Transfer....Pages 329-356 Front Matter....Pages 357-357 Mapping and Visualizing Spatial Genome Organization....Pages 359-383 Developmental Roles of Histone H3 Variants and Their Chaperones....Pages 385-419 Epigenetics in Development, Differentiation and Reprogramming....Pages 421-448 Genomic Imprinting....Pages 449-465 Front Matter....Pages 467-467 Transcription Factories....Pages 469-489 Front Matter....Pages 467-467 Dynamics and Transport of Nuclear RNA....Pages 491-513