The Flaviviruses: Pathogenesis And Immunity, Volume 60 (advances In Virus Research) (vol 2 Vol 60)

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity , the second volume of The Flaviviruses , examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. * Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. * New, detailed information on the pathogenesis and immunology of the Flavivirus family. * Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. * Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. * An exhaustive compendium of current and past knowledge on the Flavivirus family Content: Advisory Board Page ii Preface to the Flaviviruses Pages ix-xi Preface to volume 60 The FlavivirusES:Pathogenesis and Immunity Pages xiii-xiv Molecular Determinants of Virulence: The Structural and Functional Basis for Flavivirus Attenuation Original Research Article Pages 1-42 Robert J Hurrelbrink, Peter C McMinn Genetic resistance to flaviviruses Original Research Article Pages 43-85 Margo A. Brinton, Andrey A. Perelygin Immunobiology of mosquito-borne encephalitic flaviviruses Original Research Article Pages 87-120 Arno Müllbacher, Mario Lobigs, Eva Lee Immune Modulation by Flaviviruses Original Research Article Pages 121-155 Nicholas J.C. King, Bimmi Shrestha, Alison M. Kesson Mechanisms of Dengue virus-induced cell death Original Research Article Pages 157-186 Marie-Pierre Courageot, Adeline Catteau, Philippe Desprès Dynamics of Flavivirus Infection in Mosquitoes Original Research Article Pages 187-232 Laura D Kramer, Gregory D Ebel Dynamics of infection in tick vectors and at the tick–host interface Original Research Article Pages 233-272 P.A Nuttall, M Labuda Pathogenesis of flavivirus encephalitis Original Research Article Pages 273-342 Thomas J Chambers, Michael S Diamond Pathogenesis and Pathophysiology of Yellow Fever Original Research Article Pages 343-395 Thomas P Monath, Alan D.T Barrett Immunology and Immunopathogenesis of Dengue Disease Original Research Article Pages 397-419 Alan L. Rothman Neutralization and Antibody-Dependent Enhancement of Dengue Viruses Original Research Article Pages 421-467 Scott B Halstead Index Pages 469-486 Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts. Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. New, detailed information on the pathogenesis and immunology of the Flavivirus family. Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. An exhaustive compendium of current and past knowledge on the Flavivirus family Molecular determinants of virulence : the structural and functional basis for flavivirus attenuation / Robert J. Hurrelbrink and Peter C. McMinn Genetic resistance to flaviviruses / Margo A. Brinton and Andrey A. Perelygin Immunobiology of mosquito-borne encephalitic flaviviruses / Arno Mullbacher, Mario Lobigs, and Eva Lee Immune modulation by flaviviruses / Nicholas J. C. King, Bimmi Shrestha, and Alison M. Kesson Mechanisms of dengue virus-induced cell death / Marie-Pierre Courageot, Adeline Catteau, and Phillipe Despres Dynamics of flaviviruses infection in mosquitoes / Laura D. Kramer and Gregory D. Ebel Dynamics of infection in tick vectors and at the tick-host interface / P. A. Nuttall and M. Labuda Pathogenesis of flavivirus encephalitis / Thomas J. Chambers and Michael S. Diamond Pathogenesis and pathopysiology of yellow fever / Thomas P. Monath and Alan D. T. Barrett Immunobiology and immunopathogenesis of dengue disease / Alan L. Rothman Neutralization and antibody-dependent enhancement of dengue viruses / Scott B. Halstead. In recent years, the molecular and genetic basis for flavivirus attenuation has received increased attention.