The EBMT handbook : hematopoietic stem cell transplantation and cellular therapies

This Open Access 7 th edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers’ knowledge and practice skills. Front Matter ....Pages i-xl Front Matter ....Pages 1-1 HSCT: Historical Perspective (Rainer Storb)....Pages 3-9 The EBMT: History, Present, and Future (Alois Gratwohl, Mohamad Mohty, Jane Apperley)....Pages 11-17 The Role of Unrelated Donor Registries in HSCT (Irina Evseeva, Lydia Foeken, Alejandro Madrigal)....Pages 19-25 The HSCT Unit (Walid Rasheed, Dietger W. Niederwieser, Mahmoud Aljurf)....Pages 27-34 JACIE Accreditation of HSCT Programs (Riccardo Saccardi, Eoin McGrath, John A. Snowden)....Pages 35-40 Statistical Methods in HSCT and Cellular Therapies (Simona Iacobelli, Liesbeth C. de Wreede)....Pages 41-46 Front Matter ....Pages 47-47 Biological Properties of HSC: Scientific Basis for HSCT (Alessandro Aiuti, Serena Scala, Christian Chabannon)....Pages 49-56 Biological Properties of Cells Other Than HSCs (Attilio Bondanza, Ulrike Koehl, Andrea Hoffmann, Antoine Toubert)....Pages 57-60 Histocompatibility (Eric Spierings, Katharina Fleischhauer)....Pages 61-68 Clinical and Biological Concepts for Mastering Immune Reconstitution After HSCT: Toward Practical Guidelines and Greater Harmonization (Jürgen Kuball, Jaap Jan Boelens)....Pages 69-74 Front Matter ....Pages 75-75 Evaluation and Counseling of Candidates (Enric Carreras, Alessandro Rambaldi)....Pages 77-86 Donor Selection for Adults and Pediatrics (Francis Ayuk, Adriana Balduzzi)....Pages 87-97 Conditioning (Arnon Nagler, Avichai Shimoni)....Pages 99-107 Bone Marrow Harvesting for HSCT (Norbert Claude Gorin)....Pages 109-115 Mobilization and Collection of HSC (Kai Hübel)....Pages 117-122 Collection of HSC in Children (Volker Witt, Christina Peters)....Pages 123-126 Processing, Cryopreserving and Controlling the Quality of HSCs (Patrick Wuchter)....Pages 127-130 Procurement and Management of Cord Blood (Sergio Querol, Vanderson Rocha)....Pages 131-136 Graft Manipulation (Michael Schumm, Peter Lang, Rupert Handgretinger)....Pages 137-142 Documentation of Engraftment and Chimerism After HSCT (Peter Bader)....Pages 143-147 Short- and Long-Term Controls After HSCT (Montserrat Rovira, Maria Suárez-Lledó)....Pages 149-153 Front Matter ....Pages 155-155 Vascular Access (Simone Cesaro, Federica Minniti)....Pages 157-161 Transfusion Support (Hubert Schrezenmeier, Sixten Körper, Britta Höchsmann, Christof Weinstock)....Pages 163-169 Nutritional Support (Annic Baumgartner, Philipp Schuetz)....Pages 171-176 GVHD Prophylaxis (Immunosuppression) (David Michonneau, Gérard Socié)....Pages 177-182 Management ATG (SIRS) (Francesca Bonifazi)....Pages 183-187 Infection Control and Isolation Procedures (Malgorzata Mikulska)....Pages 189-195 General Management of the Patient: Specific Aspects of Children (Francesca Riccardi, Elio Castagnola)....Pages 197-205 Vaccinations (Rafael de la Cámara)....Pages 207-219 Psychological Morbidity and Support (Alice Polomeni, Enrique Moreno, Frank Schulz-Kindermann)....Pages 221-227 Clinically Relevant Drug Interactions in HSCT (Tiene Bauters)....Pages 229-235 Role of Nursing in HSCT (Aleksandra Babic, John Murray)....Pages 237-243 Ethical Issues in HSCT (Khaled El-Ghariani, Jean-Hugues Dalle)....Pages 245-249 Quality of Life Assessment After HSCT for Pediatric and Adults (Anna Barata, Heather Jim)....Pages 251-256 Front Matter ....Pages 257-257 Neutropenic Fever (Malgorzata Mikulska)....Pages 259-264 Bacterial Infections (Diana Averbuch)....Pages 265-272 Invasive Fungal Infections (Johan A. Maertens)....Pages 273-280 Viral Infections (Per Ljungman, Jan Styczynski, Hermann Einsele)....Pages 281-290 Other Life-Threatening Infections (Rodrigo Martino)....Pages 291-299 Bleeding and Thrombotic Complications (Shruti Chaturvedi, Binsah George, Bipin N. Savani)....Pages 301-306 Graft Failure (David Valcárcel, Anna Sureda)....Pages 307-313 Early Complications of Endothelial Origin (Enric Carreras, Maribel Diaz-Ricart)....Pages 315-322 Acute Graft-Versus-Host Disease (Ernst Holler, Hildegard Greinix, Robert Zeiser)....Pages 323-330 Chronic Graft-Versus-Host Disease (Daniel Wolff, Anita Lawitschka)....Pages 331-345 Post transplant Lymphoproliferative Syndromes (Jan Styczynski, Sebastian Giebel)....Pages 347-352 Iron Overload (Emanuele Angelucci)....Pages 353-356 Secondary Neoplasia (Other than PTLPS) (André Tichelli)....Pages 357-363 Front Matter ....Pages 365-365 Ocular and Oral Complications (Shahrukh K. Hashmi)....Pages 367-371 Hepatic Complications (Tapani Ruutu, Enric Carreras)....Pages 373-379 Gastrointestinal Complications (Grzegorz W. Basak)....Pages 381-386 Haemorrhagic Cystitis and Renal Dysfunction (Simone Cesaro)....Pages 387-391 Noninfectious Pulmonary Complications (Enric Carreras, Kenneth R. Cooke)....Pages 393-401 Neurological Complications (Rémy Duléry)....Pages 403-407 Skin, Hair and Musculoskeletal Complications (Francis Ayuk, Bipin N. Savani)....Pages 409-413 Cardiovascular Diseases and Metabolic Syndrome (Diana M. Greenfield, John A. Snowden)....Pages 415-420 Endocrine Disorders, Fertility and Sexual Health (Nina Salooja, Zeev Shoham, Jean-Hugues Dalle)....Pages 421-427 Front Matter ....Pages 429-429 Monitoring Minimal Residual Disease in ALL and AML (Peter Bader, Hermann Kreyenberg, Gert Ossenkoppele)....Pages 431-436 Prevention and Treatment of Relapse by Drugs (Nicolaus Kröger)....Pages 437-442 Delayed Transfer of Immune Cells or the Art of Donor Lymphocyte Infusion (J. H. Frederik Falkenburg, Christoph Schmid, Hans Joachim Kolb, Franco Locatelli, Jürgen Kuball)....Pages 443-448 Cellular Therapy with Engineered T Cells, Efficacy and Side Effects (Attilio Bondanza, Chiara Bonini, Boris Fehse, Michael Hudecek)....Pages 449-456 Mechanisms of Immune Resistance (Luca Vago, Francesco Dazzi)....Pages 457-460 Regulatory Aspects of ATMP Versus Minimally Manipulated Immune Cells (Eoin McGrath, Christian Chabannon)....Pages 461-464 Front Matter ....Pages 465-465 At-Home HSCT (Francesc Fernandez-Avilés, Gonzalo Gutiérrez-García)....Pages 467-471 Umbilical Cord Blood Transplantation in Children and Adults (Jaime Sanz, Paul Veys, Vanderson Rocha)....Pages 473-478 Haploidentical HSCT (Fabio Ciceri, Andrea Bacigalupo, Arjan Lankester, Alice Bertaina)....Pages 479-486 Photopheresis in Adults and Pediatrics (Hildegard Greinix)....Pages 487-491 Overweight and Obese Patients (Claudia Langebrake)....Pages 493-498 HSCT in Elderly Patients (Rafael F. Duarte, Isabel Sánchez-Ortega)....Pages 499-503 Front Matter ....Pages 505-505 Acute Myeloid Leukemia in Adults (Jurjen Versluis, Jan J. Cornelissen, Charles Craddock, Miguel Á. Sanz, Jonathan Canaani, Arnon Nagler)....Pages 507-521 Acute Myeloid Leukemia in Children (Brenda E. S. Gibson, Martin G. Sauer, Persis Amrolia)....Pages 523-530 Acute Lymphoblastic Leukemia in Adults (Matthias Stelljes, David I. Marks)....Pages 531-538 Acute Lymphoblastic Leukemia in Children and Adolescents (Christina Peters, Franco Locatelli, Peter Bader)....Pages 539-545 Myelodysplastic Syndromes (Marie Robin, Theo de Witte)....Pages 547-556 Pediatric MDS Including Refractory Cytopenia and Juvenile Myelomonocytic Leukemia (Charlotte M. Niemeyer)....Pages 557-560 Myelodysplastic/Myeloproliferative Neoplasms (Francesco Onida, Yves Chalandon)....Pages 561-568 Myeloproliferative Neoplasms (Nicolaus Kröger, Yves Chalandon)....Pages 569-578 Severe Aplastic Anemia and PNH (Régis Peffault de Latour, Antonio Risitano, Carlo Dufour)....Pages 579-585 Fanconi’s Anemia and Other Hereditary Bone Marrow Failure Syndromes (Cristina Díaz de Heredia, Marc Bierings, Jean-Hugues Dalle, Francesca Fioredda, Brigitte Strahm)....Pages 587-593 Hemoglobinopathies (Sickle Cell Disease and Thalassemia) (Barbara Cappelli, Eliane Gluckman, Khaled Ghanem, Miguel R. Abboud)....Pages 595-601 Multiple Myeloma (Joan Bladé, Benedetto Bruno, Mohamad Mohty)....Pages 603-607 Systemic Light Chain Amyloidosis (Monique Minnema, Stefan Schönland)....Pages 609-614 POEMS Syndrome and Disease Produced by Other Monoclonal Immunoglobulins (Gordon Cook, Montserrat Rovira)....Pages 615-619 Follicular Lymphoma (Stephen Robinson)....Pages 621-626 Chronic Lymphocytic Leukemia (Johannes Schetelig, Peter Dreger)....Pages 627-632 Diffuse Large B-Cell Lymphoma (Norbert Schmitz, Matthias Stelljes, Ali Bazarbachi)....Pages 633-641 Mantle Cell Lymphoma (Sascha Dietrich)....Pages 643-646 Other T- and B-Aggressive Lymphomas and Lymphomas Associated with HIV (Kai Hübel, Silvia Montoto)....Pages 647-651 Classical Hodgkin’s Lymphoma (Anna Sureda, Carmen Martínez)....Pages 653-662 Primary Immunodeficiencies (Michael Albert, Arjan Lankester, Andrew Gennery)....Pages 663-670 Inborn Errors of Metabolism and Osteopetrosis (Robert Wynn, Ansgar Schulz)....Pages 671-676 Autoimmune Disease (Tobias Alexander, Basil Sharrack, Montserrat Rovira, Dominique Farge, John A. Snowden)....Pages 677-683 Solid Tumours (Ruth Ladenstein, Evgenia Glogova, Francesco Lanza)....Pages 685-698 Back Matter ....Pages 699-702