The Duration and Safety of Osteoporosis Treatment : Anabolic and Antiresorptive Therapy

Providing a comprehensive review of short-and long-term adverse events of both antiresorptive and anabolic drugs, this practical guide updates the clinician on the pathophysiology of osteoporosis and the principles behind our present and future pharmaceuticals. Leading practitioners in the field examine all current literature and data regarding the duration and safety of these therapies, with recommendations for clinicians on decision-making and best practices for osteoporosis patients. An overview of the pathophysiology and epidemiology of osteoporosis and discussion of both anabolic and antiresorptive drugs is followed by fracture risk assessment and an examination of treatment failures. Next, a number of chapters are dedicated to the diagnosis, presentation and management of atypical femur fractures and osteonecrosis of the jaw (ONJ), each of which are significant patient concerns when using these osteoporosis treatments. The introduction and utilization of drug holidays is also discussed, as well as the long-term outlook for management of osteoporotic patients. Written and edited by experts in the field, __The Duration and Safety of Osteoporosis Treatment__ is a balanced resource for researchers, practitioners and policy-makers alike for clinical decision-making and patient care. Front Matter....Pages i-xvi Osteoporosis: Pathophysiology and Epidemiology....Pages 1-16 Antiresorptives....Pages 17-36 Anabolics....Pages 37-59 Tools for Assessing Fracture Risk and for Treatment Monitoring....Pages 61-83 Treatment Failure....Pages 85-94 Epidemiology of Atypical Subtrochanteric and Femoral Shaft Fractures....Pages 95-106 Bisphosphonate-Related Atypical Femur Fractures and Their Radiographic Features....Pages 107-124 Factors Contributing to Atypical Femoral Fractures....Pages 125-136 Clinical Presentation of Atypical Femur Fractures....Pages 137-140 Effects of Antiresorptive Therapy on Bone Microarchitecture....Pages 141-152 Management of Atypical Femoral Fractures....Pages 153-162 Osteonecrosis of the Jaw: Clinicopathologic and Radiologic Features....Pages 163-184 Epidemiology of Osteonecrosis of the Jaws from Antiresorptive Treatment....Pages 185-192 Management of Osteonecrosis of the Jaw in Patients Receiving Antiresorptive Treatment....Pages 193-202 Long-Term Efficacy and Safety of Treatments for Osteoporosis....Pages 203-232 Management of Drug Holidays....Pages 233-237 Patients Who Do Not Take Their Osteoporosis Medications: Can We Help Them Become Compliant?....Pages 239-253 Fractures and Healing on Antiresorptive Therapy....Pages 255-264 Antiresorptive Therapy, Mortality and Cancer Incidence....Pages 265-278 Other Safety Concerns....Pages 279-293 The Impact of Regulatory and Scientific Organizations’ Recommendations on Clinical Decision-Making....Pages 295-308 Integrated Clinical View on Long-Term Management of Patients with Osteoporosis....Pages 309-320 Conclusions....Pages 321-325 Back Matter....Pages 327-338 Providing a comprehensive review of short-and long-term adverse events of both antiresorptive and anabolic drugs, this practical guide updates the clinician on the pathophysiology of osteoporosis and the principles behind our present and future pharmaceuticals. Leading practitioners in the field examine all current literature and data regarding the duration and safety of these therapies, with recommendations for clinicians on decision-making and best practices for osteoporosis patients. An overview of the pathophysiology and epidemiology of osteoporosis and discussion of both anabolic and antiresorptive drugs is followed by fracture risk assessment and an examination of treatment failures. Next, a number of chapters are dedicated to the diagnosis, presentation and management of atypical femur fractures and osteonecrosis of the jaw (ONJ), each of which are significant patient concerns when using these osteoporosis treatments. The introduction and utilization of drug holidays is also discussed, as well as the long-term outlook for management of osteoporotic patients. Written and edited by experts in the field, The Duration and Safety of Osteoporosis Treatment is a balanced resource for researchers, practitioners and policy-makers alike for clinical decision-making and patient care.--Résumé de l'éditeur