مفاهیم ریشه‌ای توسعه سلامت و بیماری

Winner of 2016 BMA Medical Award for Basic and Clinical Sciences The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field Content: Front Matter,Copyright,Dedication,List of Contributors,AcknowledgmentsEntitled to full textChapter 1 - The Developmental Origins of Health and Disease (DOHaD) Concept: Past, Present, and Future, Pages 1-15, Peter D. Gluckman, Tatjana Buklijas, Mark A. Hanson Chapter 2 - Historical Perspective of Developmental Origins of Health and Disease in Humans, Pages 17-32, Lewis P. Rubin Chapter 3 - DOHaD and the Periconceptional Period, a Critical Window in Time, Pages 33-47, Congshan Sun, Miguel A. Velazquez, Tom P. Fleming Chapter 4 - Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various Developmental Origins of Health and Diseases Effects, Pages 49-62, Martha Susiarjo Chapter 5 - Perinatal Neurohormonal Programming and Endocrine Disruption, Pages 63-87 Chapter 6 - Parental Nutrition and Developmental Origins of Health and Disease, Pages 89-102, Miguel A. Velazquez, Congshan Sun, Tom P. Fleming Chapter 7 - Maternal Prenatal Stress and the Developmental Origins of Mental Health: The Role of Epigenetics, Pages 103-126, Kieran J. O’Donnell, Vivette Glover Chapter 8 - Epigenetics in the Developmental Origin of Cardiovascular Disorders, Pages 127-141, Jeffrey S. Gilbert Chapter 9 - Developmental Effects of Endocrine-Disrupting Chemicals in the Ovary and on Female Fertility, Pages 143-170, Mehmet Uzumcu, Aparna Mahakali Zama Chapter 10 - Developmental and Epigenetic Origins of Male Reproductive Pathologies, Pages 171-189, Carlos Guerrero-Bosagna Chapter 11 - Developmental Origins of Childhood Asthma and Allergic Conditions—Is There Evidence of Epigenetic Regulation?, Pages 191-210, Steve Turner Chapter 12 - Immune Disorders, Epigenetics, and the Developmental Origins of Health and Disease, Pages 211-234, Rodney R. Dietert, Amrie C. Grammer Chapter 13 - Neurobehavioral Disorders and Developmental Origins of Health and Disease, Pages 235-266, Curt A. Sandman, Quetzal A. Class, Laura M. Glynn, Elysia Poggi Davis Chapter 14 - Metabolic Disorders and Developmental Origins of Health and Disease, Pages 267-289, Sara E. Pinney Chapter 15 - The Developmental Origins of Renal Dysfunction, Pages 291-314, James S.M. Cuffe, Sarah L. Walton, Karen M. Moritz Chapter 16 - Cancer and Developmental Origins of Health and Disease—Epigenetic Reprogramming as a Mediator, Pages 315-336, Shuk-Mei Ho, Ana Cheong, Sarah To, Vinothini Janakiram, Pheruza Tarapore, Yuet-Kin Leung Chapter 17 - Epigenetic Regulation of Gastrointestinal Epithelial Barrier and Developmental Origins of Health and Disease, Pages 337-360, J.P. Lallès, C. Michel, V. Theodorou, J.P. Segain Chapter 18 - How the Father Might Epigenetically Program the Risk for Developmental Origins of Health and Disease Effects in His Offspring, Pages 361-375, Kristin E. Murphy, Timothy G. Jenkins, Douglas T. Carrell Chapter 19 - Linkage between In Utero Environmental Changes and Preterm Birth, Pages 377-387, Markus Velten, Lynette K. Rogers Chapter 20 - Sexual Dimorphism and DOHaD through the Lens of Epigenetics: Genetic, Ancestral, Developmental, and Environmental Origins from Previous to the Next Generation(s), Pages 389-424, Claudine Junien, Sara Fneich, Polina Panchenko, Sarah Voisin, Anne Gabory Chapter 21 - Transgenerational Epigenetic Inheritance: Past Exposures, Future Diseases, Pages 425-437, Carlos Guerrero-Bosagna Chapter 22 - The Placenta and Developmental Origins of Health and Disease, Pages 439-461, Jane K. Cleal, Rohan M. Lewis Chapter 23 - The Moral and Legal Relevance of DOHaD Effects for Pregnant Mothers, Pages 463-480, Michele Loi, Marianna Nobile Chapter 24 - Introduction to Moms in Motion (MIM), Pages 481-483 Chapter 25 - Reversing Harmful Developmental Origins of Health and Disease Effects, Pages 485-504, Mei-Wei Chang, Susan Nitzke, Roger Brown, M Jean Brancheau Egan, Kobra Eghtedary, Cheryl S. Rosenfeld Chapter 26 - Informational Resources for Developmental Origins of Health and Disease Research, Pages 505-521 Index, Pages 523-542

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring.

The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring.

It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples.

• Informs how everyday choices pregnant women make can impact child development
• Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress)
• Includes a boxed-in area in each chapter for further references and resources to keep up with the field
• Features video interviews with the authors and other key leaders in the field

"The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or conversely promote the health of the offspring. This book mines the existing literature of a variety of disciplines, from toxicology to nutrition to epigenetics, to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother's diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, and neurobehavioral disorders, and increased risk of cancer, to list but a few examples. Importantly, the common thread of how in utero and postnatal environmental changes may lead to DOHaD effects is through various epigenetic changes. The Epigenome and Developmental Origins of Health and Disease is a unique resource not only for geneticists and epigeneticists, but also for toxicologists, obestetricians, gynecologists, neurobiologists, nutritionists, physiologists, and psychologists."-- Page 4 of cover This text synthesises the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or, conversely, to promote the health of the offspring. It mines the existing literature from a variety of disciplines, from toxicology to nutrition to epigenetics, to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring