The Dental Pulp [recurso electrónico] Biology, Pathology, and Regenerative Therapies

This book provides a detailed update on our knowledge of dental pulp and regenerative approaches to therapy. It is divided into three parts. The pulp components are first described, covering pulp cells, extracellular matrix, vascularization, and innervation as well as pulp development and aging. The second part is devoted to pulp pathology and includes descriptions of the differences between reactionary and reparative dentin, the genetic alterations leading to dentinogenesis imperfecta and dentin dysplasia, the pulp reaction to dental materials, adverse impacts of bisphenol A, and the effects of fluorosis, dioxin, and other toxic agents. The final part of the book focuses on pulp repair and regeneration. It includes descriptions of various in vitro and in vivo (animal) experimental approaches, definition of the pulp stem cells with special focus on the stem cell niches, discussion of the regeneration of a living pulp, and information on new strategies that induce pulp mineralization Front Matter....Pages i-x Front Matter....Pages 1-1 Pulp Development....Pages 3-11 Pulp Anatomy and Characterization of Pulp Cells....Pages 13-33 Pulp Extracellular Matrix....Pages 35-46 Strategies for Tracking the Origin and Fate of Odontoblasts and Pulp Cell Progenitors....Pages 47-59 Pulp Vascularization and Its Regulation by the Microenvironment....Pages 61-74 Dental Pulp Innervation....Pages 75-95 Inflammatory Processes in the Dental Pulp....Pages 97-112 Pulp Aging: Fibrosis and Calcospherites....Pages 113-121 Front Matter....Pages 123-123 Pulp Inflammation: From the Reversible Pulpitis to Pulp Necrosis During Caries Progression....Pages 125-139 Reactionary and Reparative Dentin-Like Structures....Pages 141-154 Genetic Alterations: Heritable Dentin Defects....Pages 155-168 Pulp Reactions to Dental Materials....Pages 169-183 Effects of Bisphenol A on the Dental Pulp....Pages 185-190 Fluoride Effects on the Dentin-Pulp Complex....Pages 191-199 Front Matter....Pages 201-201 Experimental In Vivo Approaches of Pulp Regeneration....Pages 203-218 Pulp Stem Cells: Niches of Stem Cells....Pages 219-236 Regeneration of the Living Pulp....Pages 237-250 Scaffolds for Pulp Repair and Regeneration....Pages 251-265 Regenerative Endodontics: Regeneration or Repair?....Pages 267-276 Back Matter....Pages 277-282