The Coronin Family of Proteins (Subcellular Biochemistry, 48)

table of contents Introduction Christoph S. Clemen, Vasily Rybakin and Ludwig Eichinger Section I: THE WD- AND KELCH-REPEAT SUPERFAMILIES 1. Phylogenetic, Structural and Functional Relationships between WD and Kelch-Repeat Proteins Andrew M. Hudson and Lynn Cooley 2. Diversity of WD-Repeat Proteins Temple F. Smith SECTION II: HISTORY, PHYLOGENY, AND STRUCTURE 3. A Brief History of the Coronin Family Eugenio L. de Hostos 4. Molecular Phylogeny and Evolution of the Coronin Gene Family Reginald O. Morgan and M. Pilar Fernandez 5. Coronin Structure and Implications Bernadette McArdle and Andreas Hofmann Section III: COMMON AND DIVERSE FUNCTIONS 6. Coronin: The Double-Edged Sword of Actin Dynamics Meghal Gandhi and Bruce L. Goode 7. Invertebrate Coronins Maria C. Shina and Angelika A. Noegel 8. Evolutionary and Functional Diversity of Coronin Proteins Charles-Peter Xavier, Ludwig Eichinger, M. Pilar Fernandez, Reginald O. Morgan and Christoph S. Clemen 9. Role of Mammalian Coronin 7 in the Biosynthetic Pathway Vasily Rybakin Section IV: CLINICAL RELEVANCE 10. Coronin 1 in Innate Immunity Jean Pieters 11. The Role of Mammalian Coronins in Development and Disease David W. Roadcap, Christoph S. Clemen and James E. Bear

the Coronins, First Described In Dictyostelium Discoideum In 1991, Have Been Detected In All Eukaryotes Except Plants. They Belong To The Superfamily Of Wd40-repeat Proteins And Represent A Large Family Of Proteins, Which Are Often Involved In Cytoskeletal Functions. Phylogenetic Studies Clearly Distinguish 12 Subfamilies Of Which Six Exclusively Occur In Vertebrates. In The Present Book We Have Made A Sincere Attempt To Provide A Comprehensive Overview On All Aspects Of Coronin Proteins Including History, Structure, Subcellular Localization And Function In Different Organisms. In Addition, We Also Included A General Overview On The Wd40 Family Of Proteins And The Structurally Related Kelch Family. The Book Should Be Of Interest For Scientists Outside The Field, But Is More Importantly Intended As A Fast And Competent Guide For Newcomers As Well As Doctoral And Postdoctoral Scientists To Coronin Research In All Its Facets.

Phylogenetic, structural, and functional relationships between WD and kelch repeat proteins / Andrew M. Hudson and Lynn Cooley Diversity of WD repeat proteins / Temple F. Smith A brief history of the coronin family / Eugenio L. de Hostos Molecular phylogeny and evolution of the coronin gene family / Reginald O. Morgan and M. Pilar Fernandez Coronin structure and implications / Bernadette McArdle and Andreas Hofmann Coronin : the double-edged sword of actin dynamics / Meghal Gandhi and Bruce L. Goode Invertebrate coronins / Maria C. Shina and Angelika A. Noegel Evolutionary and functional diversity of coronin proteins / Charles Peter Xavier ... [et al.] Role of mammalian coronin 7 in the biosynthetic pathway / Vasily Rybaki Coronin 1 in innate immunity / Jean Pieters The role of mammalian coronins in development and disease / David W. Roadcap, Christoph S. Clemen, and James E. Bear. Front Matter....Pages i-xvi The Coronin Family of Proteins....Pages 1-5 Phylogenetic, Structural and Functional Relationships between WD- and Kelch-Repeat Proteins....Pages 6-19 Diversity of WD-Repeat proteins....Pages 20-30 A Brief History of the Coronin Family....Pages 31-40 Molecular Phylogeny and Evolution of the Coronin Gene Family....Pages 41-55 Coronin Structure and Implications....Pages 56-71 Coronin: The Double-Edged Sword of Actin Dynamics....Pages 72-87 Invertebrate Coronins....Pages 88-97 Evolutionary and Functional Diversity of Coronin Proteins....Pages 98-109 Role of Mammalian Coronin 7 in the Biosynthetic Pathway....Pages 110-115 Coronin 1 in Innate Immunity....Pages 116-123 The Role of Mammalian Coronins in Development and Disease....Pages 124-135 Back Matter....Pages 137-139 Edited By P. Bräunlish ; With Contributions By P. Bräunlich .. [et Al.]. Includes Index. Bibliography: P. 301-326.