The Chromosomal Imbalance Theory of Cancer : The Autocatalyzed Progression of Aneuploidy Is Carcinogenesis

Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of cancer therapy and prevention. The book posits that the autocatalyzed progression of aneuploidy is carcinogenesis. The clarity and unifying simplicity of the theory of chromosomal imbalance has the potential to fundamentally alter the course of cancer research, prevention, diagnosis and treatment. Rasnick, who worked in the pharmaceutical/biotech industry to develop protease inhibitors and founded three biotech companies, explains the chromosomal imbalance (aneuploidy) theory of cancer, as opposed to the gene mutation theory. He describes how gene mutations are not powerful enough to cause cancer; how cancer is initiated and why progression takes years or decades; and the global or macroscopic characteristics that identify cancer: anaplasia, autonomous growth, metastasis, abnormal cell morphology, DNA indices from 0.5 to over 2, genetic instability, and the high level of membrane-bound and secreted proteins responsible for invasiveness and loss of contact inhibition. He explains the common failure of chemotherapy and why cancer cells often become drug resistant, measures for detecting cancer and monitoring its progression, and non-toxic strategies for therapy and prevention. Distributed by CRC Press. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com) Front Cover......Page 1 Contents......Page 16 Preface......Page 6 1. Introducing Cancer......Page 20 2. Boveri's Theory of Cancer was Ahead of its Time......Page 31 3. Genesis of "The Enemy Within"?......Page 41 4. Gene Mutation Theory of Cancer......Page 73 5. The Chromosomal Imbalance Theory of Cancer......Page 104 6. Theory of Chromosomal Imbalance Solves Mysteries and Paradoxes......Page 151 7. New Perspectives for Cancer Prevention, Diagnosis and Therapy......Page 214 8. Conclusion......Page 254 References......Page 259 Color Plate Section......Page 336