The Chemokines: Biology of the Inflammatory Peptide Supergene Family II (Advances in Experimental Medicine and Biology, 351)

The first symposium in this series was held at the Royal College of Surgeons of England in December 1988 and was entitled "Novel Neutrophil Stimulating Peptides". That symposium successfully brought together the majority of laboratories working in the area of interleukin-8 and related peptides; see Immunology Today 10: 146-147 (1989). The Second International Symposium on Chemotactic Cytokines was held at the same venue in June 1990, and a much-increased attendance reflected the accelerating pace of work in the area of these chemotactic cytokines. The proceedings of that meeting were published in Advances in Experimental Medicine and Biology, vol. 305 (1991). The rapid advances made in the field of chemotactic cytokines over the last 18 months necessitated a third Symposium in this series to collate and place in perspective an explosion of new data. The Third International Symposium on Chemotactic Cytokines was held between August 31 and September 1, 1992 in Baden-bei-Wien, Austria. However, the lack of a clear nomenclature system was creating some confusion in the area, especially as new factors continue to be discovered and classified as family members. In the past, these inflammatory mediators had been placed arbitrarily under the broad heading of "intercrines" or "chemotactic cytokines" with no clear classification guidelines to follow. This nomenclature issue was addressed at the Symposium, where investigators in the field were invited to reach a consensus regarding a collective name for these mediators. The resulting decision was to identify the major family as chemokines, to replace all previous terms. Front Matter....Pages i-xv Chemotactic and Inflammatory Cytokines — CXC and CC Proteins....Pages 1-11 Induction of Chemotactic Cytokines by Minimally Oxidized Ldl....Pages 13-18 The Immunopathology of Chemotactic Cytokines....Pages 19-28 Receptor/Ligand Interactions in the C-C Chemokine Family....Pages 29-37 Adhesion Molecules in Acute and Chronic Lung Inflammation....Pages 39-45 Monocyte Chemotactic Protein-1 (MCP-1): Signal Transduction and Involvement in the Regulation of Macrophage Traffic in Normal and Neoplastic Tissues....Pages 47-54 Secretion of Monocyte Chemoattractant Protein-1 (MCP-1) by Human Mononuclear Phagocytes....Pages 55-64 L-Arginine/Nitric Oxide Pathway: A Possible Signal Transduction Mechanism for the Regulation of the Chemokine IL-8 in Human Mesangial Cells....Pages 65-75 Some Aspects of NAP-1/IL-8 Pathophysiology II: Chemokine Secretion by Exocrine Glands....Pages 77-85 Molecular Mechanism of Interleukin-8 Gene Expression....Pages 87-97 Basophil Activation by Members of the Chemokine Superfamily....Pages 99-110 Monocyte Chemotactic Proteins Related to Human MCP-1....Pages 111-118 Platelets Secrete an Eosinophil-Chemotactic Cytokine which is a Member of the C-C-Chemokine Family....Pages 119-127 Neutrophil-Activating Peptide ENA-78....Pages 129-137 The Effects of Human Recombinant MIP-1α, MIP-1β, and Rantes on the Chemotaxis and Adhesion of T Cell Subsets....Pages 139-146 Promiscuity of Ligand Binding in the Human Chemokine Beta Receptor Family....Pages 147-153 Structural and Functional Characterization of the Interleukin-8 Receptors....Pages 155-169 Elucidation of Structure Function Relationships in the IL-8 Family by X-ray Crystallography....Pages 171-182 Overview of Chemokines....Pages 183-186 Regulation of Cytokine Secretion by Poxvirus Encoded Proteins....Pages 187-187 Interleukin-8 Expression in Gastric Cancer....Pages 188-188 Synergistic II-8 Synthesis by Human Peritoneal Mesothelial Cells (Hpmc) Following II-1β and Tnfα Treatment....Pages 188-189 Detection of a Potent Chemotactic Activity in Supernatants from Human Monocytes Stimulated with Endothelin-1 (ET-1)....Pages 189-189 Glioblastoma Secrete Mcp-1, A Monocyte Chemotactic Factor....Pages 190-190 Neutrophil Chemotactic Activity In The Bronchoalveolar Lavage Fluid Of Asthmatics....Pages 190-190 The Chemoattractant Properties of Interleukin-4....Pages 191-191 Il-8 Induced Chemotaxis of Peripheral Neutrophils in Children with Cystic Fibrosis (Cf)....Pages 191-192 Unusual Properties in Vitro and in Vivo of 198, an Antibody that Recognizes Rabbit Cd11b....Pages 192-192 Effect of Monocyte Chemotactic Cytokine Gene Transfer on Macrophage Infiltration, Growth and Metastatic Behaviour of a Murine Melanoma....Pages 192-193 Expression of Monocyte Chemotactic Protein-1 (Mcp-1) by Monocytes and Endothelial Cells Exposed to Thrombin....Pages 193-194 IL-8 Production During Urinary Tract Infection....Pages 194-194 Nap-1/IL-8 Receptor Expression on Human Neutrophils....Pages 194-194 Macrophage-Derived Neutrophil Chemotactic Factor (MNCF) Induces Neutrophil Migration Through Lectin-Like Activity....Pages 195-195 Interleukin 8 Release From Human Pmn Is Modified By Airborne Particulated Matter....Pages 195-196 Interleukin-8 Induces the Expression of Hla-Dr Antigen on Human Keratinocytes....Pages 196-196 Cloning, Sequencing and Expression of Ovine Neutrophilattractant Protein-1/IL-8 and Monocyte Chemoattractant Protein-1....Pages 197-197 Inhibition of Lps-Mediated Responses in Human Whole Blood by Recombinant Bactericidal/Permeability Increasing Protein....Pages 197-198 The Activity of IL-8 in Combination with Gmcsf and TNFα....Pages 198-198 Induction of IL-8 in Inflammatory Bowel Disease....Pages 198-199 Elevated Circulating and Tissue IL-8 in Alcoholic Hepatitis....Pages 199-199 Expression of Monocyte Chemoattractant Protein-1 in Basal Keratinocytes of Psoriatic Lesions....Pages 200-200 IL-8 Concentration in β-Thalassaemia and After Bone Marrow Transplantation....Pages 200-201 Cytokine Production in Felty’s Syndrome....Pages 201-201 The Lymphocyte Attractant Effects of Interleukins lα and 8 a Are Not Due to the Release of a Secondary Chemoattractant Factor....Pages 202-202 Serial Changes in Circulating Interleukin-8 and Neutrophil Elastase after Major Surgery....Pages 202-203 Role of Interleukin-8 in the Pathogenesis of Neutrophilmediated acute Lung Injury....Pages 203-203 Interleukin-8 in Acute Meningococcal Infections; Correlation with Severity of Disease....Pages 204-204 IL-6 And IL-8 Levels in Patients with Rheumatoid Arthritis....Pages 204-205 Plasma Interleukin 8 Levels in Patients with Septic Shock....Pages 205-205 Inhibitory Effect of Protease-Inhibitor for Production of Interleukin 8 (IL-8) and Polymorphonuclear Leukocyte Elastase (Pmne)....Pages 205-206 Effect of Diluents and Capture Antibodies on Detection of NAP-1 by Sandwich Elisa....Pages 206-206 Do the Two Types of IL-8 Receptors on Human Neutrophils Mediate Different Cellular Responses?....Pages 207-207 Interleukin 8 Plays a Fundamental Role in Inflammatory Processes in Vivo....Pages 207-208 Endothelial Cell Binding of NAP-1/IL-8: Role in Neutrophil Emigration....Pages 208-208 Heparin Binding of NAP-1/IL-8: The Effect of Heparin and Related Glycosaminoglycans on in Vitro Neutrophil Responses to NAP-1/IL-8....Pages 209-209 The Effect of 5-Lipoxygenase Inhibitors on the Activity of IL-8....Pages 209-210 Chemotactic Cytokine Generation by Human Lung Microvascular Endothelial Cells: Differential Regulation by Gamma Interferon....Pages 210-210 The Effect of Haemofiltration on Circulating Cytokines in Children Undergoing Cardiopulmonary Bypass: A Preliminary Study....Pages 211-211 Interleukin 8 (IL-8) is Produced by the Bronchoalveolar Lavage Cell Population from Patients with Active but not Inactive Sarcoidosis....Pages 211-212 Gastric Interleukin-8 and Interleukin-8 IgA Autoantibodies in Helicobacter Pylori Infection....Pages 212-212 Eosinophils from Allergic Individuals, but not Normal Individuals, Show Chemotactic Responsiveness to NAF/IL-8....Pages 213-213 Monocyte Chemotactic Peptide-1 (Mcp-1) and NAP-1/IL-8 Formation in Baboon Septicemia are Partially TNF Dependent....Pages 213-213 Increased Expression of Monocyte Chemoattractant Protein-1 (Mcp-1) in Glomeruli From Rats With Anti Thy 1.1 Glomerulonephritis....Pages 214-215 Role of Macrophage Inflammatory Protein (Mip)-Lα in Granulomatous Inflammation....Pages 215-215 Nap-1/Il-8 Is a Weak Inducer of T Cell Migration Into Skin....Pages 216-216 IL-8-Stimulated Lymphocyte Locomotion in Antigen- Or Mitogen-Activated Mononuclear Cell Cultures....Pages 216-216 In Vivo Studies of Rantes and the Recruitment of Lymphocytes to Inflammatory Sites....Pages 217-217 IL-1 and TNF Induced Up-Regulation of IL-8 Receptors on Human Epidermal Cells....Pages 217-218 Promiscuity Of Ligand Binding In The Chemokine Beta Receptor Family....Pages 218-218 Differentiation-Specific Expression of a Novel G Protein-Coupled Cytokine Receptor from Burkitt’s Lymphoma....Pages 218-219 Signal Transduction by Monocyte Chemotactic Protein-1 (MCP-1) and Cross-Desensitization with Other Members of the Chemokine-β Subfamily in Human Monocytes....Pages 219-219 Mechanisms of Zymosan Induced IL-8 Generation in Vivo....Pages 220-220 The Effects of Intranasal Challenge with Interleukin-8 (IL-8)....Pages 220-221 Interleukin-8 Down-Regulates the Oxidative Burst Induced by Tumor Necrosis Factor Alpha in Neutrophils Adherent to Fibronectin....Pages 221-221 Identification of a Novel Tumor-Derived Monocyte Chemotactic Factor: Relationship with Tissue Inhibitor of Metalloproteinase....Pages 222-222 α-Melanocyte Stimulating Hormone Inhibits Human Epidermal Cell and Polymorphonuclear Leukocyte Chemotaxis....Pages 222-223 Mip-1 Alpha: A Potent Stem Cell Inhibitor....Pages 223-223 Back Matter....Pages 225-227