The chemistry of penicillin : report on a collaborative investigation by American and British chemists under the joint sponsorship of the Office of Scientific Research and Development, Washington, D.C., and the Medical Research Council, London

This book makes available, for interested scientists to procure, absorb, and evaluate, the vast body of information on the research and results of the work on the chemistry of penicillin done in England and the United States during the war. The National Academy of Sciences arranged for the preparation of this summary, Dr. H. T. Clarke and Dr. J. R. Johnson representing the United States on the editorial board, and Sir Robert Robinson representing Britain. The body of the work was prepared by more than 60 outstanding biochemists and biophysicists, who describe the phases of research to which they contributed the most. The work of 23 academic, medical, industrial, and government laboratories is reported. Originally published in 1949. The **Princeton Legacy Library** uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. Preface Contents I. Brief History of the Chemical Study of Penicillin II. The Earlier Investigations relating to 2-Pentenylpenicillin III. The Chemistry of n-Amylpenicillin up to December 1943 IV. Status of the Research on the Structure of Benzylpenicillin in December 1943 V. Isolation and Characterization of the Various Penicillins VI. Penillic Acids and Penillamines VII. Review of Certain Investigations on the Structure of Benzylpenicillin during 1944-1945 VIII. Some Inactivation and Degradation Reactions not included in Chapters IV and VII IX. Desthiobenzylpenicillin and Other Hydrogenolysis Products of Benzylpenicillin X. The Thiocyanate Derivative of Benzylpenicillin Methyl Ester XI. The X-Ray Crystallographic Investigation of the Structure of Penicillin XII. Identification and Crystallography of Penicillins and Related Compounds by X-Ray Diffraction Methods XIII. Infrared Spectroscopic Studies on the Structure of Penicillin XIV. Other Physical Methods XV. The Constitution of Penicillins XVI. Penicillamine, Its Analogs and Homologs XVII. Penilloaldehydes and Penaldic Acids XVIII. The Penilloic and Penicilloic Acids and Their Derivatives and Analogs XIX. Biosynthesis of Penicillins XX. Chemical Modifications of Natural Penicillins XXI. Oxazoles and Oxazolones XXII. Attempted Syntheses of Penicillins XXIII. The Condensation of Oxazolones and D-Penicillamine and the Resultant Antibiotic Activity XXIV. Methyl Benzylpseudopenicillinate XXV. Thiazolidines XXVI. The Chemistry of β-Lactams XXVII. The γ-Lactam of Benzylhomopenicilloic Acid and Related Compounds XXVIII. Synthetic Benzylpenicillin XXIX. Assay of Penicillins XXX. Appendix SUBJECT INDEX This book makes available, for interested scientists to procure, absorb, and evaluate, the vast body of information on the research and results of the work on the chemistry of penicillin done in England and the United States during the war. The National Academy of Sciences arranged for the preparation of this summary, Dr. H.T. Clarke and Dr. J.R. Johnson representing the United States on the editorial board, and Sir Robert Robinson representing Britain. The body of the work was prepared by more than 60 outstanding biochemists and biophysicists, who describe the phases of research to which they contributed the most. The work of 23 academic, medical, industrial, and government laboratories is reported. Originally published in 1949. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905 This book makes available, for interested scientists to procure, absorb, and evaluate, the vast body of information on the research and results of the work on the chemistry of penicillin done in England and the United States during the war. The National Academy of Sciences arranged for the preparation of this summary, Dr. H. T. Clarke and Dr. J. R. Johnson representing the United States on the editorial board, and Sir Robert Robinson representing Britain. The body of the work was prepared by more than 60 outstanding biochemists and biophysicists, who describe the phases of research to which they contributed the most. The work of 23 academic, medical, industrial, and government laboratories is reported.Originally published in 1949.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905