The Chemical Biology of DNA Damage: GEACINTOV:DNA DAMAGE O-BK

Content: Chapter 1 Introduction and Perspectives on the Chemistry and Biology of DNA Damage (pages 1–20): Prof. Nicholas E. Geacintov and Prof. Suse Broyde Chapter 2 Chemistry of Inflammation and DNA Damage: Biological Impact of Reactive Nitrogen Species (pages 21–51): Michael S. De Mott and Peter C. Dedon Chapter 3 Oxidatively Generated Damage to Isolated and Cellular DNA (pages 53–80): Jean Cadet, Thierry Douki and Jean?Luc Ravanat Chapter 4 Role of Free Radical Reactions in the Formation of DNA Damage (pages 81–104): Vladimir Shafirovich and Nicholas E. Geacintov Chapter 5 DNA Damage Caused by Endogenously Generated Products of Oxidative Stress (pages 105–130): Charles G. Knutson and Lawrence J. Marnett Chapter 6 Polycyclic Aromatic Hydrocarbons: Multiple Metabolic Pathways and the DNA Lesions Formed (pages 131–155): Trevor M. Penning Chapter 7 Aromatic Amines and Heterocyclic Aromatic Amines: From Tobacco Smoke to Food Mutagens (pages 157–183): Robert J. Turesky Chapter 8 Genotoxic Estrogen Pathway: Endogenous and Equine Estrogen Hormone Replacement Therapy (pages 185–199): Judy L. Bolton and Gregory R. J. Thatcher Chapter 9 Interstrand DNA Cross?Linking 1,N2?Deoxyguanosine Adducts Derived from ?,??Unsaturated Aldehydes: Structure–Function Relationships (pages 201–216): Michael P. Stone, Hai Huang, Young?Jin Cho, Hye?Young Kim, Ivan D. Kozekov, Albena Kozekova, Hao Wang, Irina G. Minko, R. Stephen Lloyd, Thomas M. Harris and Carmelo J. Rizzo Chapter 10 Structure–Function Characteristics of Aromatic Amine?DNA Adducts (pages 217–238): Bongsup Cho Chapter 11 Mechanisms of Base Excision Repair and Nucleotide Excision Repair (pages 239–260): Orlando D. Scharer and Arthur J. Campbell Chapter 12 Recognition and Removal of Bulky DNA Lesions by the Nucleotide Excision Repair System (pages 261–298): Yuqin Cai, Konstantin Kropachev, Marina Kolbanovskiy, Alexander Kolbanovskiy, Prof. Suse Broyde, Dinshaw J. Patel and Prof. Nicholas E. Geacintov Chapter 13 Impact of Chemical Adducts on Translesion Synthesis in Replicative and Bypass DNA Polymerases: From Structure to Function (pages 299–330): Robert L. Eoff, Martin Egli and Peter Guengerich Chapter 14 Elucidating Structure–Function Relationships in Bulky DNA Lesions: From Solution Structures to Polymerases (pages 331–352): Prof. Suse Broyde, Lihua Wang, Dinshaw J. Patel and Prof. Nicholas E. Geacintov Chapter 15 Translesion Synthesis and Mutagenic Pathways in Escherichia coli Cells (pages 353–380): Sushil Chandani and Edward L. Loechler Chapter 16 Insight into the Molecular Mechanism of Translesion DNA Synthesis in Human Cells using Probes with Chemically Defined DNA Lesions (pages 381–397): Zvi Livneh Chapter 17 DNA Damage and Transcription Elongation: Consequences and RNA Integrity (pages 399–437): Kristian Dreij, John A. Burns, Alexandra Dimitri, Lana Nirenstein, Taissia Noujnykh and David A. Scicchitano Bringing the power of biochemical analysis to toxicology, this modern reference explains genotoxicity at the molecular level, showing the links between a DNA lesion and the resulting cellular or organismic response. Clearly divided into two main sections, Part 1 focuses on selected examples of important DNA lesions and their biological impact, while the second part covers current advances in assessing and predicting the genotoxic effects of chemicals, taking into account the biological responses mediated by the DNA repair, replication and transcription machineries.A ready reference for bio A Modern Reference On A Key Topic In Biochemical Toxicology That Reaches Out Into Molecular Biology, Molecular Medicine And Environmental Science, The Chemical Biology Of Dna Damage Covers Basic Concepts As Well As The Analysis And Prediction Of Genotoxicty At The Molecular Level.