The Cell membrane : its role in interaction with the outside world : a volume in honor of Professor Herman Kalckar on his seventy-fifth birthday

The contents of this book reflect a symposium held in honor of Professor Herman Kalckar's seventy-fifth birthday. His impact on the history of biochemistry is reflected by the diversity of the contributions of his former students and friends. Speakers came from Asia, Europe, and the United States to discuss both procaryotes and eukaryotes. The unifying theme was the cell membrane, both its organization and its function. Ektobiology, a topic that has held the attention of Professor Kalckar for many years, was clearly defined as a central topic in biology. This subject deals with the key structure whereby the cell interacts with the outside world and which, in a sense, defines the boundary between what is the cell and what is not. Topics discussed include the biogenesis of membrane proteins, sugars and lipids, the role of membrane components in osmoregula­ tion, and mechanisms of nutrient transport. Of great interest is the system for surface recognition evolved in vertebrates, exemplified by the HLA system of man. Neoplasia causes changes in the cell membrane that may be of significant future potential in the diagnosis and treatment of malignancies as well as in the understanding of the process of transformation. The changes in glycosphingolipids and carbohydrate antigens in relation to oncogenesis are detailed. I should like to recognize Doctors Kurt J. Isselbacher, Phillips W. Robbins, Victor Ginsburg, and Hiroshi Nikaido for their ,assistance in organizing the symposium. Ms. Jean Brumbaugh deserves special thanks for putting this book together. Front Matter....Pages N1-ix Herman Kalckar: An Appreciation....Pages 1-3 Front Matter....Pages 5-5 Outer Membrane Permeability of Gram-Negative Bacteria in their Interaction with the Outside World....Pages 7-17 Biogenesis of Membrane Lipoproteins in Bacteria....Pages 19-31 Periplasmic Membrane-Derived Oligosaccharides and Osmoregulation in Escherichia Coli ....Pages 33-43 Approaches to the Biochemistry of Protein Secretion in Bacteria....Pages 45-54 Two Mechanisms of Biosyntheses of Antibiotic Peptides....Pages 55-66 Transmembrane Channels Made by Colicins....Pages 67-69 Significance of Lipopolysaccharide Structure for Questions of Taxonomy and Phylogenetical Relatedness of Gram-Negative Bacteria....Pages 71-83 Cloning and Expression of Genes Encoding the nupG Nucleoside Transport System in Escherichia Coli....Pages 85-99 From Herman Kalckar’s Galactose Recapture to the Galactose Chemoreceptor....Pages 101-107 Glycerol Utilization by Facilitated Diffusion Coupled to Phosphorylation in Bacteria....Pages 109-130 Mechanisms of Cellular Protein Localization....Pages 131-146 Front Matter....Pages 147-147 Ektobiology, Growth Control and Cancer....Pages 149-159 Carbohydrate Antigens of Cell Surfaces Detected by Monoclonal Antibodies....Pages 161-168 Studies on a Cancer Associated Glycoprotein....Pages 169-179 Glycosphingolipids as Markers for Development and Differentiation and as Regulators of Cell Proliferation....Pages 181-201 Probing the Macrophage Surface: Alterations in Specific Surface Carbohydrates Accompany Macrophage Activation....Pages 203-215 Harderian Gland as a Model Organ for Study of Lipid Metabolism....Pages 217-237 Surface Changes Observed on Neural Tissues During Development of Avian Embryos....Pages 239-251 Energy-Requiring Regulation of Hexose Transport, as Studied in Fibroblast Cultures of a Metabolic Mutant....Pages 253-263 Front Matter....Pages 147-147 Human Histocompatibility Antigens: Genes and Proteins....Pages 265-270 When Ecto and Endobiology Merge: Monitoring Ischemic Cell Death....Pages 271-279 Eukaryotic Transport Control: The Turnover Years....Pages 281-294 Back Matter....Pages 295-297 The contents of this book reflect a symposium held in honor of Professor Herman Kalckar's seventy-fifth birthday. His impact on the history of biochemistry is reflected by the diversity of the contributions of his former students and friends. Speakers came from Asia, Europe, and the United States to discuss both procaryotes and eukaryotes. The unifying theme was the cell membrane, both its organization and its function. Ektobiology, a topic that has held the attention of Professor Kalckar for many years, was clearly defined as a central topic in biology. This subject deals with the key structure whereby the cell interacts with the outside world and which, in a sense, defines the boundary between what is the cell and what is not. Topics discussed include the biogenesis of membrane proteins, sugars and lipids, the role of membrane components in osmoregulaƯ tion, and mechanisms of nutrient transport. Of great interest is the system for surface recognition evolved in vertebrates, exemplified by the HLA system of man. Neoplasia causes changes in the cell membrane that may be of significant future potential in the diagnosis and treatment of malignancies as well as in the understanding of the process of transformation. The changes in glycosphingolipids and carbohydrate antigens in relation to oncogenesis are detailed. I should like to recognize Doctors Kurt J. Isselbacher, Phillips W. Robbins, Victor Ginsburg, and Hiroshi Nikaido for their, assistance in organizing the symposium. Ms. Jean Brumbaugh deserves special thanks for putting this book together